Bioinformatics-Driven Structural and Pharmacological Analysis of SLITRK1 in Tourette Syndrome: Impact of S656M Mutation Using Molecular Dynamics, Docking, and Reinforcement Learning

Bioinformatics-Driven Structural and Pharmacological Analysis of SLITRK1 in Tourette Syndrome: Impact of S656M Mutation Using Molecular Dynamics, Docking, and Reinforcement Learning

SLITRK1 is a critical protein involved in neural development and is associated with various neurological disorders, including Tourette Syndrome. This study investigates the structural dynamics, intrinsic disorder propensity, and pharmacological interactions of SLITRK1, with a particular focus on ami...

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Bibliographic Details
Main Authors: Emre Aktaş, Alirıza İslim, Kevser Kübra Kırboğa, Derya Yıldız, Nehir Özdemir Özgentürk, Mithun Rudrapal, Johra Khan, Raghu Ram Achar, Ekaterina Silina, Natalia Manturova, Victor Stupin
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Computation
Subjects:
SLITRK1 protein
protein–protein interactions
drug interactions
amino acid substitutions
molecular dynamics simulations of proteins
molecular docking
Online Access:https://www.mdpi.com/2079-3197/13/2/29
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