Evolution of carbapenemase activity in the class C β-lactamase ADC-1

Evolution of carbapenemase activity in the class C β-lactamase ADC-1

ABSTRACT Antibiotic resistance in bacteria poses a significant threat to public health. Among dozens of available antimicrobial agents, carbapenems are used as drugs of choice for the treatment of serious infections caused by pathogens resistant to other antibiotics. However, their usefulness has be...

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Bibliographic Details
Main Authors: Nichole K. Stewart, Marta Toth, Monolekha Bhattacharya, Clyde A. Smith, Sergei B. Vakulenko
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
class C carbapenemase
carbapenem
antibiotic resistance
crystal structure
kinetics
Acinetobacter baumannii
Online Access:https://journals.asm.org/doi/10.1128/mbio.00185-25
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