Hydrogel Containing an Oxygen Carrier With Hemoglobin From the Marine Worm Arenicola marina (M101) in the Management of Deep Burns
Summary:. A 34-year-old patient with no medical history was admitted following severe thermal burns (>85% of the body surface area), including deep second- and third-degree injuries. Surgical management aimed to heal the entire upper body (thorax, abdomen, and back) using topical oxygen therapy (...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2025-07-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006930 |
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| author | Ugo Lancien, MD, MSc Pierre-Joachim Mahe, MD Aline Lepelletier, MD Elisabeth Leize-Zal, MD Laurent Lantieri, MD, PhD Pierre Perrot, MD, PhD |
| author_facet | Ugo Lancien, MD, MSc Pierre-Joachim Mahe, MD Aline Lepelletier, MD Elisabeth Leize-Zal, MD Laurent Lantieri, MD, PhD Pierre Perrot, MD, PhD |
| author_sort | Ugo Lancien, MD, MSc |
| collection | DOAJ |
| description | Summary:. A 34-year-old patient with no medical history was admitted following severe thermal burns (>85% of the body surface area), including deep second- and third-degree injuries. Surgical management aimed to heal the entire upper body (thorax, abdomen, and back) using topical oxygen therapy (TOT) on the deep second-degree burns, without burn excision or skin grafting, while processing conventional management of the remaining burned areas alongside specialized intensive care. TOT was performed using an innovative oxygenating dressing (HEMHealing, Hemarina SA, Morlaix, France) combined with conventional excisional, allograft, and autograft management (4 surgical steps) on the hands, upper limbs, and lower limbs; the protocol enabled graft-free healing of the abdomen, thorax, and back within around 5 weeks. Despite a prolonged healing time (47 d, beyond the dogma of 2–3 wk), at 12 months follow-up, the scars showed very little inflammation and no hypertrophy on the trunk and the back. The patient did not require compression garments on TOT-treated sites. We report the use of this innovative dressing—in parallel with resuscitation and conventional surgery—and the very favorable evolution of this patient confirms this choice in retrospect. We now need to consider other cases and studies to validate our initial clinical results. |
| format | Article |
| id | doaj-art-0a9bda054d8249569bf4eb35ad53fcf8 |
| institution | DOAJ |
| issn | 2169-7574 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj-art-0a9bda054d8249569bf4eb35ad53fcf82025-08-20T03:13:41ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742025-07-01137e693010.1097/GOX.0000000000006930202507000-00009Hydrogel Containing an Oxygen Carrier With Hemoglobin From the Marine Worm Arenicola marina (M101) in the Management of Deep BurnsUgo Lancien, MD, MSc0Pierre-Joachim Mahe, MD1Aline Lepelletier, MD2Elisabeth Leize-Zal, MD3Laurent Lantieri, MD, PhD4Pierre Perrot, MD, PhD5From the * Department of Plastic and Reconstructive Surgery, University Hospital of Nantes, Nantes, France‡ Department of Anesthesia and Intensive Care Unit, University Hospital of Nantes, Nantes, France§ Department of Clinical Pharmacy, University Hospital of Nantes, Nantes, France¶ Hemarina SA, Aéropôle Centre, Morlaix, France∥ Department of Plastic and Reconstructive Surgery, Georges Pompidou University Hospital, APHP, Paris, France.From the * Department of Plastic and Reconstructive Surgery, University Hospital of Nantes, Nantes, FranceSummary:. A 34-year-old patient with no medical history was admitted following severe thermal burns (>85% of the body surface area), including deep second- and third-degree injuries. Surgical management aimed to heal the entire upper body (thorax, abdomen, and back) using topical oxygen therapy (TOT) on the deep second-degree burns, without burn excision or skin grafting, while processing conventional management of the remaining burned areas alongside specialized intensive care. TOT was performed using an innovative oxygenating dressing (HEMHealing, Hemarina SA, Morlaix, France) combined with conventional excisional, allograft, and autograft management (4 surgical steps) on the hands, upper limbs, and lower limbs; the protocol enabled graft-free healing of the abdomen, thorax, and back within around 5 weeks. Despite a prolonged healing time (47 d, beyond the dogma of 2–3 wk), at 12 months follow-up, the scars showed very little inflammation and no hypertrophy on the trunk and the back. The patient did not require compression garments on TOT-treated sites. We report the use of this innovative dressing—in parallel with resuscitation and conventional surgery—and the very favorable evolution of this patient confirms this choice in retrospect. We now need to consider other cases and studies to validate our initial clinical results.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006930 |
| spellingShingle | Ugo Lancien, MD, MSc Pierre-Joachim Mahe, MD Aline Lepelletier, MD Elisabeth Leize-Zal, MD Laurent Lantieri, MD, PhD Pierre Perrot, MD, PhD Hydrogel Containing an Oxygen Carrier With Hemoglobin From the Marine Worm Arenicola marina (M101) in the Management of Deep Burns Plastic and Reconstructive Surgery, Global Open |
| title | Hydrogel Containing an Oxygen Carrier With Hemoglobin From the Marine Worm Arenicola marina (M101) in the Management of Deep Burns |
| title_full | Hydrogel Containing an Oxygen Carrier With Hemoglobin From the Marine Worm Arenicola marina (M101) in the Management of Deep Burns |
| title_fullStr | Hydrogel Containing an Oxygen Carrier With Hemoglobin From the Marine Worm Arenicola marina (M101) in the Management of Deep Burns |
| title_full_unstemmed | Hydrogel Containing an Oxygen Carrier With Hemoglobin From the Marine Worm Arenicola marina (M101) in the Management of Deep Burns |
| title_short | Hydrogel Containing an Oxygen Carrier With Hemoglobin From the Marine Worm Arenicola marina (M101) in the Management of Deep Burns |
| title_sort | hydrogel containing an oxygen carrier with hemoglobin from the marine worm arenicola marina m101 in the management of deep burns |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006930 |
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