Hematopoietic stem cell a reservoir of innate immune memory
Hematopoietic stem cells (HSCs) are a rare, long-lived and multipotent population that give rise to majority of blood cells and some tissue-resident immune cells. There is growing evidence that inflammatory stimuli can trigger persistent reprogramming in HSCs that enhances or inhibits the cellular f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1491729/full |
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| author | Lucas Ruffinatto Yann Groult Johanna Iacono Sandrine Sarrazin Bérengère de Laval |
| author_facet | Lucas Ruffinatto Yann Groult Johanna Iacono Sandrine Sarrazin Bérengère de Laval |
| author_sort | Lucas Ruffinatto |
| collection | DOAJ |
| description | Hematopoietic stem cells (HSCs) are a rare, long-lived and multipotent population that give rise to majority of blood cells and some tissue-resident immune cells. There is growing evidence that inflammatory stimuli can trigger persistent reprogramming in HSCs that enhances or inhibits the cellular functions of these HSCs and their progeny in response to subsequent infections. This newly discovered property makes HSCs a reservoir for innate immune memory. The molecular mechanisms underlying innate immune memory in HSCs are similar to those observed in innate immune cells, although their full elucidation is still pending. In this review, we examine the current state of knowledge on how an inflammatory response leads to reprogramming of HSCs. Understanding the full spectrum of consequences of reshaping early hematopoiesis is critical for assessing the potential benefits and risks under physiological and pathological conditions. |
| format | Article |
| id | doaj-art-0a9af749aebc4ca5b6a962f4ba6d95bc |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-0a9af749aebc4ca5b6a962f4ba6d95bc2025-08-20T02:38:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14917291491729Hematopoietic stem cell a reservoir of innate immune memoryLucas RuffinattoYann GroultJohanna IaconoSandrine SarrazinBérengère de LavalHematopoietic stem cells (HSCs) are a rare, long-lived and multipotent population that give rise to majority of blood cells and some tissue-resident immune cells. There is growing evidence that inflammatory stimuli can trigger persistent reprogramming in HSCs that enhances or inhibits the cellular functions of these HSCs and their progeny in response to subsequent infections. This newly discovered property makes HSCs a reservoir for innate immune memory. The molecular mechanisms underlying innate immune memory in HSCs are similar to those observed in innate immune cells, although their full elucidation is still pending. In this review, we examine the current state of knowledge on how an inflammatory response leads to reprogramming of HSCs. Understanding the full spectrum of consequences of reshaping early hematopoiesis is critical for assessing the potential benefits and risks under physiological and pathological conditions.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1491729/fullhematopoietic stem and progenitor cells (HSPCs)innate immune memoryinflammationepigeneticemergency hematopoiesismetabolism |
| spellingShingle | Lucas Ruffinatto Yann Groult Johanna Iacono Sandrine Sarrazin Bérengère de Laval Hematopoietic stem cell a reservoir of innate immune memory Frontiers in Immunology hematopoietic stem and progenitor cells (HSPCs) innate immune memory inflammation epigenetic emergency hematopoiesis metabolism |
| title | Hematopoietic stem cell a reservoir of innate immune memory |
| title_full | Hematopoietic stem cell a reservoir of innate immune memory |
| title_fullStr | Hematopoietic stem cell a reservoir of innate immune memory |
| title_full_unstemmed | Hematopoietic stem cell a reservoir of innate immune memory |
| title_short | Hematopoietic stem cell a reservoir of innate immune memory |
| title_sort | hematopoietic stem cell a reservoir of innate immune memory |
| topic | hematopoietic stem and progenitor cells (HSPCs) innate immune memory inflammation epigenetic emergency hematopoiesis metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1491729/full |
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