Synthesis and Characterization of Fe3O4/Chitosan/TiO2 Nanoparticle Novel Nanocarrier and Investigation of In Vitro Release of Vancomycin on HeLa Cancer Cell
Nanocarrier systems have gained significant attention in recent decades as an alternative to conventional drug delivery methods, which often suffer from various limitations. In this study, Fe3O4/chitosan/TiO2 nanoparticles were synthesized as a novel nanocarrier for targeted drug delivery. The loadi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/ijbm/6164871 |
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| author | Elahe Mohamadi Bian Ayoub Moghadam |
| author_facet | Elahe Mohamadi Bian Ayoub Moghadam |
| author_sort | Elahe Mohamadi Bian |
| collection | DOAJ |
| description | Nanocarrier systems have gained significant attention in recent decades as an alternative to conventional drug delivery methods, which often suffer from various limitations. In this study, Fe3O4/chitosan/TiO2 nanoparticles were synthesized as a novel nanocarrier for targeted drug delivery. The loading efficiency and controlled release behavior of vancomycin from the nanocarrier were evaluated under in vitro conditions using HeLa cancer cells. The in vitro study of the drug release behavior showed that the implementation of a titania coating significantly diminishes the drug release rate. Specifically, approximately 90 ± 0.2% of the drug is released over a period of 16 h for samples without the titania coating, while samples with the coating exhibit a release time of 25 h. The MTT assay indicates that the application of TiO2 nanoparticles on the nanocarrier resulted in a decrease in cell viability from 90 ± 3% to 50 ± 2% at concentrations of 100 μg/mL and 500 μg/mL, respectively. These findings highlight the potential of the Fe3O4/chitosan/TiO2 nanocarrier as an efficient system for controlled and targeted drug delivery applications. |
| format | Article |
| id | doaj-art-0a9a054b25604608a1acbc63e4d93ca1 |
| institution | Kabale University |
| issn | 1687-8795 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-0a9a054b25604608a1acbc63e4d93ca12025-08-20T03:53:12ZengWileyInternational Journal of Biomaterials1687-87952025-01-01202510.1155/ijbm/6164871Synthesis and Characterization of Fe3O4/Chitosan/TiO2 Nanoparticle Novel Nanocarrier and Investigation of In Vitro Release of Vancomycin on HeLa Cancer CellElahe Mohamadi Bian0Ayoub Moghadam1Department of Materials Science and EngineeringDepartment of Materials Science and EngineeringNanocarrier systems have gained significant attention in recent decades as an alternative to conventional drug delivery methods, which often suffer from various limitations. In this study, Fe3O4/chitosan/TiO2 nanoparticles were synthesized as a novel nanocarrier for targeted drug delivery. The loading efficiency and controlled release behavior of vancomycin from the nanocarrier were evaluated under in vitro conditions using HeLa cancer cells. The in vitro study of the drug release behavior showed that the implementation of a titania coating significantly diminishes the drug release rate. Specifically, approximately 90 ± 0.2% of the drug is released over a period of 16 h for samples without the titania coating, while samples with the coating exhibit a release time of 25 h. The MTT assay indicates that the application of TiO2 nanoparticles on the nanocarrier resulted in a decrease in cell viability from 90 ± 3% to 50 ± 2% at concentrations of 100 μg/mL and 500 μg/mL, respectively. These findings highlight the potential of the Fe3O4/chitosan/TiO2 nanocarrier as an efficient system for controlled and targeted drug delivery applications.http://dx.doi.org/10.1155/ijbm/6164871 |
| spellingShingle | Elahe Mohamadi Bian Ayoub Moghadam Synthesis and Characterization of Fe3O4/Chitosan/TiO2 Nanoparticle Novel Nanocarrier and Investigation of In Vitro Release of Vancomycin on HeLa Cancer Cell International Journal of Biomaterials |
| title | Synthesis and Characterization of Fe3O4/Chitosan/TiO2 Nanoparticle Novel Nanocarrier and Investigation of In Vitro Release of Vancomycin on HeLa Cancer Cell |
| title_full | Synthesis and Characterization of Fe3O4/Chitosan/TiO2 Nanoparticle Novel Nanocarrier and Investigation of In Vitro Release of Vancomycin on HeLa Cancer Cell |
| title_fullStr | Synthesis and Characterization of Fe3O4/Chitosan/TiO2 Nanoparticle Novel Nanocarrier and Investigation of In Vitro Release of Vancomycin on HeLa Cancer Cell |
| title_full_unstemmed | Synthesis and Characterization of Fe3O4/Chitosan/TiO2 Nanoparticle Novel Nanocarrier and Investigation of In Vitro Release of Vancomycin on HeLa Cancer Cell |
| title_short | Synthesis and Characterization of Fe3O4/Chitosan/TiO2 Nanoparticle Novel Nanocarrier and Investigation of In Vitro Release of Vancomycin on HeLa Cancer Cell |
| title_sort | synthesis and characterization of fe3o4 chitosan tio2 nanoparticle novel nanocarrier and investigation of in vitro release of vancomycin on hela cancer cell |
| url | http://dx.doi.org/10.1155/ijbm/6164871 |
| work_keys_str_mv | AT elahemohamadibian synthesisandcharacterizationoffe3o4chitosantio2nanoparticlenovelnanocarrierandinvestigationofinvitroreleaseofvancomycinonhelacancercell AT ayoubmoghadam synthesisandcharacterizationoffe3o4chitosantio2nanoparticlenovelnanocarrierandinvestigationofinvitroreleaseofvancomycinonhelacancercell |