Peripheral blood inflammatory biomarkers neutrophil/ lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index/albumin ratio predict prognosis and efficacy in non-small cell lung cancer patients receiving immunotherapy and opioids
Abstract Objective The study aimed to assess the value of pretreatment peripheral blood neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immune-inflammation index/albumin ratio (SII/ALB) for predicting immunotherapy prognosis and efficacy in Non-small cell lung carcino...
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BMC
2025-04-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-14060-9 |
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| author | Yan Lei Chengsong Cao Rui Tang Yong Liu |
| author_facet | Yan Lei Chengsong Cao Rui Tang Yong Liu |
| author_sort | Yan Lei |
| collection | DOAJ |
| description | Abstract Objective The study aimed to assess the value of pretreatment peripheral blood neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immune-inflammation index/albumin ratio (SII/ALB) for predicting immunotherapy prognosis and efficacy in Non-small cell lung carcinoma (NSCLC) treated with Immune checkpoint inhibitors (ICIs) and opioids. Methods A total of 78 NSCLC patients received ICIs and opioids were retrospectively collected. The optimal cut-off values were determined by receiver operating characteristic curves. The univariate and multivariate analysis investigated the effects of NLR, PLR, and SII/ALB on patients prognosis. Results NLR and PLR had predictive value of efficacy. SII/ALB > 17.79 was an independent risk factor for worse outcomes. Conclusion PLR and SII/ALB have predictive value of efficacy, but NLR was not. SII/ALB > 17.79 suggests a poor prognosis following immunotherapy in NSCLC patients receiving ICIs and opioids. |
| format | Article |
| id | doaj-art-0a97ef93127f402c92aea003a475ab4f |
| institution | OA Journals |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-0a97ef93127f402c92aea003a475ab4f2025-08-20T02:12:02ZengBMCBMC Cancer1471-24072025-04-012511810.1186/s12885-025-14060-9Peripheral blood inflammatory biomarkers neutrophil/ lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index/albumin ratio predict prognosis and efficacy in non-small cell lung cancer patients receiving immunotherapy and opioidsYan Lei0Chengsong Cao1Rui Tang2Yong Liu3Department of Oncology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical UniversityDepartment of Oncology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical UniversitySchool of Public Health, Faculty of Medicine, The University of QueenslandDepartment of Oncology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical UniversityAbstract Objective The study aimed to assess the value of pretreatment peripheral blood neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immune-inflammation index/albumin ratio (SII/ALB) for predicting immunotherapy prognosis and efficacy in Non-small cell lung carcinoma (NSCLC) treated with Immune checkpoint inhibitors (ICIs) and opioids. Methods A total of 78 NSCLC patients received ICIs and opioids were retrospectively collected. The optimal cut-off values were determined by receiver operating characteristic curves. The univariate and multivariate analysis investigated the effects of NLR, PLR, and SII/ALB on patients prognosis. Results NLR and PLR had predictive value of efficacy. SII/ALB > 17.79 was an independent risk factor for worse outcomes. Conclusion PLR and SII/ALB have predictive value of efficacy, but NLR was not. SII/ALB > 17.79 suggests a poor prognosis following immunotherapy in NSCLC patients receiving ICIs and opioids.https://doi.org/10.1186/s12885-025-14060-9Peripheral blood inflammatory markerImmune checkpoint inhibitorsOpioidsCancer painNon-small cell lung cancerPrognostic value |
| spellingShingle | Yan Lei Chengsong Cao Rui Tang Yong Liu Peripheral blood inflammatory biomarkers neutrophil/ lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index/albumin ratio predict prognosis and efficacy in non-small cell lung cancer patients receiving immunotherapy and opioids BMC Cancer Peripheral blood inflammatory marker Immune checkpoint inhibitors Opioids Cancer pain Non-small cell lung cancer Prognostic value |
| title | Peripheral blood inflammatory biomarkers neutrophil/ lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index/albumin ratio predict prognosis and efficacy in non-small cell lung cancer patients receiving immunotherapy and opioids |
| title_full | Peripheral blood inflammatory biomarkers neutrophil/ lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index/albumin ratio predict prognosis and efficacy in non-small cell lung cancer patients receiving immunotherapy and opioids |
| title_fullStr | Peripheral blood inflammatory biomarkers neutrophil/ lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index/albumin ratio predict prognosis and efficacy in non-small cell lung cancer patients receiving immunotherapy and opioids |
| title_full_unstemmed | Peripheral blood inflammatory biomarkers neutrophil/ lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index/albumin ratio predict prognosis and efficacy in non-small cell lung cancer patients receiving immunotherapy and opioids |
| title_short | Peripheral blood inflammatory biomarkers neutrophil/ lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index/albumin ratio predict prognosis and efficacy in non-small cell lung cancer patients receiving immunotherapy and opioids |
| title_sort | peripheral blood inflammatory biomarkers neutrophil lymphocyte ratio platelet lymphocyte ratio and systemic immune inflammation index albumin ratio predict prognosis and efficacy in non small cell lung cancer patients receiving immunotherapy and opioids |
| topic | Peripheral blood inflammatory marker Immune checkpoint inhibitors Opioids Cancer pain Non-small cell lung cancer Prognostic value |
| url | https://doi.org/10.1186/s12885-025-14060-9 |
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