P4HA2 promotes the progression of papillary thyroid cancer by enhancing degradation of IκBα to activate NF-κB signaling pathway

P4HA2 promotes the progression of papillary thyroid cancer by enhancing degradation of IκBα to activate NF-κB signaling pathway

Abstract Papillary thyroid cancer (PTC) is the most common malignancy of the endocrine system. Collagen prolyl 4-hydroxylase alpha subunit 2 (P4HA2) is a key enzyme involved in collagen metabolism. However, the expression and function of P4HA2 in PTC progression have not been well studied. Our previ...

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Bibliographic Details
Main Authors:	Ruowen Li, Mingjian Zhao, Min Sun, Yongkang Wu, Chengxu Miao, Liu Fangyu, Mengting Wu, Xiaojia Shi, Jinghui Lu, Xuetian Yue
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Cancer Cell International
Subjects:	P4HA2 Papillary thyroid carcinoma NF-κB signaling pathway Proteasome degradation Ubiquitination
Online Access:	https://doi.org/10.1186/s12935-025-03871-2
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