Association of genetic variants of hemostasis system genes with pregnancy loss in women
Abstract Background Venous thrombosis may be the cause of a complicated obstetric and gynecological history in women. One of the types of disorders in the hemostasis system is gestational thrombophilia, which can lead to various pregnancy complications. Therefore, it is important to understand the e...
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| Format: | Article |
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SpringerOpen
2025-07-01
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| Series: | Bulletin of the National Research Centre |
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| Online Access: | https://doi.org/10.1186/s42269-025-01330-6 |
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| author | Oleg A. Perevezentsev Ilgar S. Mamedov Dmitry V. Burtsev |
| author_facet | Oleg A. Perevezentsev Ilgar S. Mamedov Dmitry V. Burtsev |
| author_sort | Oleg A. Perevezentsev |
| collection | DOAJ |
| description | Abstract Background Venous thrombosis may be the cause of a complicated obstetric and gynecological history in women. One of the types of disorders in the hemostasis system is gestational thrombophilia, which can lead to various pregnancy complications. Therefore, it is important to understand the etiopathogenesis of this pathological condition, including the contribution of hereditary factors. The aim of our work Is to analyze the association of eight genetic variants (F2 20210G > A, F5 1691G > A, F7 10976G > A, F13 G > T, ITGA2 807C > T, ITGB3 1565 T > C, PAI-1 -675 5G > 4G) of the hemostasis system genes in women with pregnancy loss. Design and methods. The study included 311 women aged 20 to 38 years, who have had at least one pregnancy end in miscarriage, and 225 women in the control group. The study of the genotypes of the selected genetic variants was carried out by real-time PCR with melting curve analysis. Results A positive association was found for 4 genetic variants: F2: 20,210 G > A (OR = 11.03, CI 2.60–46.81, P < 0.001); F5 1691G > A (OR = 6.02, CI 2.52–14.38, P < 0.001); FGB: -455 G > A (OR = 5.65, CI 3.05–10.45, P < 0.001) and PAI-1 -675 5G > 4G (OR = 2.28, CI 1.54–3.39, P < 0.001). Conclusion Thus, we established an association of four genetic variants of plasma hemostatic factor genes with pregnancy loss in women. |
| format | Article |
| id | doaj-art-0a955c565eb44bdb935ee66c7c0c504e |
| institution | Kabale University |
| issn | 2522-8307 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj-art-0a955c565eb44bdb935ee66c7c0c504e2025-08-20T03:42:19ZengSpringerOpenBulletin of the National Research Centre2522-83072025-07-014911610.1186/s42269-025-01330-6Association of genetic variants of hemostasis system genes with pregnancy loss in womenOleg A. Perevezentsev0Ilgar S. Mamedov1Dmitry V. Burtsev2Rostov State Medical UniversityDepartment of Health of the City of Moscow, Scientific and Practical Center for Specialized Medical Care for Children Named After V.F. Voyno-YasenetskyRostov State Medical UniversityAbstract Background Venous thrombosis may be the cause of a complicated obstetric and gynecological history in women. One of the types of disorders in the hemostasis system is gestational thrombophilia, which can lead to various pregnancy complications. Therefore, it is important to understand the etiopathogenesis of this pathological condition, including the contribution of hereditary factors. The aim of our work Is to analyze the association of eight genetic variants (F2 20210G > A, F5 1691G > A, F7 10976G > A, F13 G > T, ITGA2 807C > T, ITGB3 1565 T > C, PAI-1 -675 5G > 4G) of the hemostasis system genes in women with pregnancy loss. Design and methods. The study included 311 women aged 20 to 38 years, who have had at least one pregnancy end in miscarriage, and 225 women in the control group. The study of the genotypes of the selected genetic variants was carried out by real-time PCR with melting curve analysis. Results A positive association was found for 4 genetic variants: F2: 20,210 G > A (OR = 11.03, CI 2.60–46.81, P < 0.001); F5 1691G > A (OR = 6.02, CI 2.52–14.38, P < 0.001); FGB: -455 G > A (OR = 5.65, CI 3.05–10.45, P < 0.001) and PAI-1 -675 5G > 4G (OR = 2.28, CI 1.54–3.39, P < 0.001). Conclusion Thus, we established an association of four genetic variants of plasma hemostatic factor genes with pregnancy loss in women.https://doi.org/10.1186/s42269-025-01330-6Genetic variantsVenous thrombosisPregnancy loss |
| spellingShingle | Oleg A. Perevezentsev Ilgar S. Mamedov Dmitry V. Burtsev Association of genetic variants of hemostasis system genes with pregnancy loss in women Bulletin of the National Research Centre Genetic variants Venous thrombosis Pregnancy loss |
| title | Association of genetic variants of hemostasis system genes with pregnancy loss in women |
| title_full | Association of genetic variants of hemostasis system genes with pregnancy loss in women |
| title_fullStr | Association of genetic variants of hemostasis system genes with pregnancy loss in women |
| title_full_unstemmed | Association of genetic variants of hemostasis system genes with pregnancy loss in women |
| title_short | Association of genetic variants of hemostasis system genes with pregnancy loss in women |
| title_sort | association of genetic variants of hemostasis system genes with pregnancy loss in women |
| topic | Genetic variants Venous thrombosis Pregnancy loss |
| url | https://doi.org/10.1186/s42269-025-01330-6 |
| work_keys_str_mv | AT olegaperevezentsev associationofgeneticvariantsofhemostasissystemgeneswithpregnancylossinwomen AT ilgarsmamedov associationofgeneticvariantsofhemostasissystemgeneswithpregnancylossinwomen AT dmitryvburtsev associationofgeneticvariantsofhemostasissystemgeneswithpregnancylossinwomen |