Impact of Severe Thermal Injury on Cardiac Contractility and Metabolism
Objective: to experimentally study cardiac functional and metabolic disturbances in the acute period of severe thermal injury. Material and methods. Experiments were carried out on 25 outbred male albino rats anesthesized with Nembutal (50 mg/kg intraperitoneally). Five-mm-thick copper plates heated...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2011-02-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/333 |
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| author | M. A. Goldzon V. T. Dolgikh |
| author_facet | M. A. Goldzon V. T. Dolgikh |
| author_sort | M. A. Goldzon |
| collection | DOAJ |
| description | Objective: to experimentally study cardiac functional and metabolic disturbances in the acute period of severe thermal injury. Material and methods. Experiments were carried out on 25 outbred male albino rats anesthesized with Nembutal (50 mg/kg intraperitoneally). Five-mm-thick copper plates heated up to 60°C were used to simulate thermal injury. Skin contact with the thermal agent lasted 15 seconds. Myocardial contractility and metabolism were examined using the specimen of the isolated isovolumically contracted heart. Results. Severe thermal injury was found to induce acute heart failure caused by cardiac bioenergy impairment, hypoxia, metabolic acidosis, and cardiomyocyte membrane destruction. Key words: thermal injury, cardiac contractility and metabolism. |
| format | Article |
| id | doaj-art-0a92f9d748d94192802aaec2b79d567e |
| institution | Kabale University |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2011-02-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-0a92f9d748d94192802aaec2b79d567e2025-08-20T03:59:40ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102011-02-017110.15360/1813-9779-2011-1-11333Impact of Severe Thermal Injury on Cardiac Contractility and MetabolismM. A. GoldzonV. T. DolgikhObjective: to experimentally study cardiac functional and metabolic disturbances in the acute period of severe thermal injury. Material and methods. Experiments were carried out on 25 outbred male albino rats anesthesized with Nembutal (50 mg/kg intraperitoneally). Five-mm-thick copper plates heated up to 60°C were used to simulate thermal injury. Skin contact with the thermal agent lasted 15 seconds. Myocardial contractility and metabolism were examined using the specimen of the isolated isovolumically contracted heart. Results. Severe thermal injury was found to induce acute heart failure caused by cardiac bioenergy impairment, hypoxia, metabolic acidosis, and cardiomyocyte membrane destruction. Key words: thermal injury, cardiac contractility and metabolism.https://www.reanimatology.com/rmt/article/view/333 |
| spellingShingle | M. A. Goldzon V. T. Dolgikh Impact of Severe Thermal Injury on Cardiac Contractility and Metabolism Общая реаниматология |
| title | Impact of Severe Thermal Injury on Cardiac Contractility and Metabolism |
| title_full | Impact of Severe Thermal Injury on Cardiac Contractility and Metabolism |
| title_fullStr | Impact of Severe Thermal Injury on Cardiac Contractility and Metabolism |
| title_full_unstemmed | Impact of Severe Thermal Injury on Cardiac Contractility and Metabolism |
| title_short | Impact of Severe Thermal Injury on Cardiac Contractility and Metabolism |
| title_sort | impact of severe thermal injury on cardiac contractility and metabolism |
| url | https://www.reanimatology.com/rmt/article/view/333 |
| work_keys_str_mv | AT magoldzon impactofseverethermalinjuryoncardiaccontractilityandmetabolism AT vtdolgikh impactofseverethermalinjuryoncardiaccontractilityandmetabolism |