Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement
Objective. Facial synkinesis is a severe sequelae of facial nerve malfunction. Once the synkinesis is established, it is extremely difficult for patients to recover. Given that the restoration of motor or sensory function after peripheral nerve injury was closely related with cortical plasticity, we...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/7235808 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850232570942324736 |
|---|---|
| author | Jia-jia Wu Ye-chen Lu Mou-xiong Zheng Xu-yun Hua Jian-guang Xu Wei Ding Chun-lei Shan |
| author_facet | Jia-jia Wu Ye-chen Lu Mou-xiong Zheng Xu-yun Hua Jian-guang Xu Wei Ding Chun-lei Shan |
| author_sort | Jia-jia Wu |
| collection | DOAJ |
| description | Objective. Facial synkinesis is a severe sequelae of facial nerve malfunction. Once the synkinesis is established, it is extremely difficult for patients to recover. Given that the restoration of motor or sensory function after peripheral nerve injury was closely related with cortical plasticity, we investigated cortical plasticity in facial synkinesis patients by the frequency-specific data which remains largely uncharacterized. Materials and Methods. Resting-state fMRI was conducted in 20 facial synkinesis patients and 19 healthy controls, and the amplitude of low-frequency fluctuation (ALFF) in five different frequency bands (slow-6: 0-0.01 Hz; slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz; slow-3: 0.073-0.167 Hz; and slow-2: 0.167-0.25 Hz) was calculated, respectively. And the relationship between ALFF and clinical outcomes was also analyzed. Results. Comparing with the healthy controls, facial synkinesis patients showed significantly different ALFF values, mainly in the sensorimotor areas. Furthermore, increased ALFF of the ipsilateral insula in the slow-6 band was significantly related with better facial nerve function. Conclusion. Increased ALFF values in the ipsilateral insula might reflect an abnormal state of hypercompensation in motor control of facial synkinesis patients. It provided valuable spatial information about the functionally aberrant regions, which implied the possible involvement of motor control system in facial synkinesis. |
| format | Article |
| id | doaj-art-0a9009c52a2e4f97a301c0d78a5a596d |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-0a9009c52a2e4f97a301c0d78a5a596d2025-08-20T02:03:08ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/72358087235808Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex InvolvementJia-jia Wu0Ye-chen Lu1Mou-xiong Zheng2Xu-yun Hua3Jian-guang Xu4Wei Ding5Chun-lei Shan6Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCenter of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCenter of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCenter of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaCenter of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaObjective. Facial synkinesis is a severe sequelae of facial nerve malfunction. Once the synkinesis is established, it is extremely difficult for patients to recover. Given that the restoration of motor or sensory function after peripheral nerve injury was closely related with cortical plasticity, we investigated cortical plasticity in facial synkinesis patients by the frequency-specific data which remains largely uncharacterized. Materials and Methods. Resting-state fMRI was conducted in 20 facial synkinesis patients and 19 healthy controls, and the amplitude of low-frequency fluctuation (ALFF) in five different frequency bands (slow-6: 0-0.01 Hz; slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz; slow-3: 0.073-0.167 Hz; and slow-2: 0.167-0.25 Hz) was calculated, respectively. And the relationship between ALFF and clinical outcomes was also analyzed. Results. Comparing with the healthy controls, facial synkinesis patients showed significantly different ALFF values, mainly in the sensorimotor areas. Furthermore, increased ALFF of the ipsilateral insula in the slow-6 band was significantly related with better facial nerve function. Conclusion. Increased ALFF values in the ipsilateral insula might reflect an abnormal state of hypercompensation in motor control of facial synkinesis patients. It provided valuable spatial information about the functionally aberrant regions, which implied the possible involvement of motor control system in facial synkinesis.http://dx.doi.org/10.1155/2019/7235808 |
| spellingShingle | Jia-jia Wu Ye-chen Lu Mou-xiong Zheng Xu-yun Hua Jian-guang Xu Wei Ding Chun-lei Shan Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement Neural Plasticity |
| title | Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement |
| title_full | Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement |
| title_fullStr | Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement |
| title_full_unstemmed | Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement |
| title_short | Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement |
| title_sort | motor control deficits in facial synkinesis patients neuroimaging evidences of cerebral cortex involvement |
| url | http://dx.doi.org/10.1155/2019/7235808 |
| work_keys_str_mv | AT jiajiawu motorcontroldeficitsinfacialsynkinesispatientsneuroimagingevidencesofcerebralcortexinvolvement AT yechenlu motorcontroldeficitsinfacialsynkinesispatientsneuroimagingevidencesofcerebralcortexinvolvement AT mouxiongzheng motorcontroldeficitsinfacialsynkinesispatientsneuroimagingevidencesofcerebralcortexinvolvement AT xuyunhua motorcontroldeficitsinfacialsynkinesispatientsneuroimagingevidencesofcerebralcortexinvolvement AT jianguangxu motorcontroldeficitsinfacialsynkinesispatientsneuroimagingevidencesofcerebralcortexinvolvement AT weiding motorcontroldeficitsinfacialsynkinesispatientsneuroimagingevidencesofcerebralcortexinvolvement AT chunleishan motorcontroldeficitsinfacialsynkinesispatientsneuroimagingevidencesofcerebralcortexinvolvement |