Antioxidative effects of phytoaromatic compounds on the cysteine of the SKCGS peptide as a critical aggregation domain of tau

Abstract Cysteine residues play a crucial role in maintaining the structural and functional integrity of proteins, but they are highly susceptible to oxidative modifications. These modifications can contribute to disorders such as Alzheimer’s disease (AD). In tau protein, the SKCGS sequence, especia...

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Bibliographic Details
Main Authors: Afsaneh Roshanfekr, Zahra Moeini, Farhad Golmohammadi, Saeed Balalaie, Arefeh Seyedarabi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-04999-x
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