NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model.

NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model.

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Cancer-driving mutations synergize with inflammatory stress signaling pathways during carcinogenesis. Drosophila melanogaster tumor models are increasingly recognized as models to inform conserved molecular mechanisms of tumorigenesis with both local and systemic effects of cancer. Although initial...

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Bibliographic Details
Main Authors: Caroline Dillard, José Teles-Reis, Ashish Jain, Marina Gonçalves Antunes, Paula Ruiz-Duran, Yanyan Qi, Roland Le Borgne, Heinrich Jasper, Tor Erik Rusten
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002663
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