NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model.
Cancer-driving mutations synergize with inflammatory stress signaling pathways during carcinogenesis. Drosophila melanogaster tumor models are increasingly recognized as models to inform conserved molecular mechanisms of tumorigenesis with both local and systemic effects of cancer. Although initial...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-04-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002663 |
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| author | Caroline Dillard José Teles-Reis Ashish Jain Marina Gonçalves Antunes Paula Ruiz-Duran Yanyan Qi Roland Le Borgne Heinrich Jasper Tor Erik Rusten |
| author_facet | Caroline Dillard José Teles-Reis Ashish Jain Marina Gonçalves Antunes Paula Ruiz-Duran Yanyan Qi Roland Le Borgne Heinrich Jasper Tor Erik Rusten |
| author_sort | Caroline Dillard |
| collection | DOAJ |
| description | Cancer-driving mutations synergize with inflammatory stress signaling pathways during carcinogenesis. Drosophila melanogaster tumor models are increasingly recognized as models to inform conserved molecular mechanisms of tumorigenesis with both local and systemic effects of cancer. Although initial discoveries of the Toll-NFκB signaling pathway in development and immunity were pioneered in Drosophila, limited information is available for its role in cancer progression. Using a well-studied cooperative RasV12-driven epithelial-derived tumor model, we here describe functions of Toll-NF-κB signaling in malignant RasV12, scrib- tumors. The extracellular Toll pathway components ModSP and PGRP-SA and intracellular signaling Kinase, Pelle/IRAK, are rate-limiting for tumor growth. The Toll pathway NFκB protein Dorsal as well as cactus/IκΒ show elevated expression in tumors with highest expression in invasive cell populations. Oncogenic RasV12, and not loss of scribble, confers increased expression and heterogenous distribution of two Dorsal isoforms, DorsalA and DorsalB, in different tumor cell populations. Mechanistic analyses demonstrates that Dorsal, in concert with the BTB-transcription factor Chinmo, drives growth and malignancy by suppressing differentiation, counteracting apoptosis, and promoting invasion of RasV12, scrib- tumors. |
| format | Article |
| id | doaj-art-0a87f6ba5c5a48fba3c2a1e349925aa5 |
| institution | DOAJ |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-0a87f6ba5c5a48fba3c2a1e349925aa52025-08-20T03:11:51ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852025-04-01234e300266310.1371/journal.pbio.3002663NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model.Caroline DillardJosé Teles-ReisAshish JainMarina Gonçalves AntunesPaula Ruiz-DuranYanyan QiRoland Le BorgneHeinrich JasperTor Erik RustenCancer-driving mutations synergize with inflammatory stress signaling pathways during carcinogenesis. Drosophila melanogaster tumor models are increasingly recognized as models to inform conserved molecular mechanisms of tumorigenesis with both local and systemic effects of cancer. Although initial discoveries of the Toll-NFκB signaling pathway in development and immunity were pioneered in Drosophila, limited information is available for its role in cancer progression. Using a well-studied cooperative RasV12-driven epithelial-derived tumor model, we here describe functions of Toll-NF-κB signaling in malignant RasV12, scrib- tumors. The extracellular Toll pathway components ModSP and PGRP-SA and intracellular signaling Kinase, Pelle/IRAK, are rate-limiting for tumor growth. The Toll pathway NFκB protein Dorsal as well as cactus/IκΒ show elevated expression in tumors with highest expression in invasive cell populations. Oncogenic RasV12, and not loss of scribble, confers increased expression and heterogenous distribution of two Dorsal isoforms, DorsalA and DorsalB, in different tumor cell populations. Mechanistic analyses demonstrates that Dorsal, in concert with the BTB-transcription factor Chinmo, drives growth and malignancy by suppressing differentiation, counteracting apoptosis, and promoting invasion of RasV12, scrib- tumors.https://doi.org/10.1371/journal.pbio.3002663 |
| spellingShingle | Caroline Dillard José Teles-Reis Ashish Jain Marina Gonçalves Antunes Paula Ruiz-Duran Yanyan Qi Roland Le Borgne Heinrich Jasper Tor Erik Rusten NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model. PLoS Biology |
| title | NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model. |
| title_full | NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model. |
| title_fullStr | NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model. |
| title_full_unstemmed | NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model. |
| title_short | NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model. |
| title_sort | nf κb signaling driven by oncogenic ras contributes to tumorigenesis in a drosophila carcinoma model |
| url | https://doi.org/10.1371/journal.pbio.3002663 |
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