Advances in hydrogels for capturing and neutralizing inflammatory cytokines
Inflammatory cytokines play a crucial role in the inflammatory response, and their aberrant expression and overproduction are closely associated with the development of many diseases. However, traditional inflammation treatment strategies are often accompanied by serious side effects, limiting their...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-06-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/20417314251342175 |
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| _version_ | 1850157851639545856 |
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| author | Hongwei Qin Ze Li Sicheng Li Jinjian Huang Jianan Ren Xiuwen Wu |
| author_facet | Hongwei Qin Ze Li Sicheng Li Jinjian Huang Jianan Ren Xiuwen Wu |
| author_sort | Hongwei Qin |
| collection | DOAJ |
| description | Inflammatory cytokines play a crucial role in the inflammatory response, and their aberrant expression and overproduction are closely associated with the development of many diseases. However, traditional inflammation treatment strategies are often accompanied by serious side effects, limiting their widespread use. In recent years, hydrogel, as a material with a three-dimensional network structure, good biocompatibility and modulability, has great potential for trapping and neutralizing inflammatory factors. Hydrogels can capture and neutralize inflammatory cytokines through various mechanisms such as electrostatic interactions, coupling with cytokine antibodies or binding nanoparticles. In addition, hydrogel microspheres, an important form of hydrogels, have excellent broad-spectrum binding of inflammatory cytokines in combination schemes with cell membranes. This article reviews recent research advances in hydrogel capture and neutralization of inflammatory cytokines, discussing the advantages of various mechanisms and their applications in different diseases. Overall, we believe that hydrogels are expected to further advance the development of therapeutic modalities for inflammatory diseases in the future. |
| format | Article |
| id | doaj-art-0a869afac83a4570a7fcd45d898b6633 |
| institution | OA Journals |
| issn | 2041-7314 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj-art-0a869afac83a4570a7fcd45d898b66332025-08-20T02:24:03ZengSAGE PublishingJournal of Tissue Engineering2041-73142025-06-011610.1177/20417314251342175Advances in hydrogels for capturing and neutralizing inflammatory cytokinesHongwei Qin0Ze Li1Sicheng Li2Jinjian Huang3Jianan Ren4Xiuwen Wu5The First Hospital of AUST, Anhui University of Science and Technology, Huainan, ChinaResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, ChinaResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, ChinaResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, ChinaResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, ChinaResearch Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, ChinaInflammatory cytokines play a crucial role in the inflammatory response, and their aberrant expression and overproduction are closely associated with the development of many diseases. However, traditional inflammation treatment strategies are often accompanied by serious side effects, limiting their widespread use. In recent years, hydrogel, as a material with a three-dimensional network structure, good biocompatibility and modulability, has great potential for trapping and neutralizing inflammatory factors. Hydrogels can capture and neutralize inflammatory cytokines through various mechanisms such as electrostatic interactions, coupling with cytokine antibodies or binding nanoparticles. In addition, hydrogel microspheres, an important form of hydrogels, have excellent broad-spectrum binding of inflammatory cytokines in combination schemes with cell membranes. This article reviews recent research advances in hydrogel capture and neutralization of inflammatory cytokines, discussing the advantages of various mechanisms and their applications in different diseases. Overall, we believe that hydrogels are expected to further advance the development of therapeutic modalities for inflammatory diseases in the future.https://doi.org/10.1177/20417314251342175 |
| spellingShingle | Hongwei Qin Ze Li Sicheng Li Jinjian Huang Jianan Ren Xiuwen Wu Advances in hydrogels for capturing and neutralizing inflammatory cytokines Journal of Tissue Engineering |
| title | Advances in hydrogels for capturing and neutralizing inflammatory cytokines |
| title_full | Advances in hydrogels for capturing and neutralizing inflammatory cytokines |
| title_fullStr | Advances in hydrogels for capturing and neutralizing inflammatory cytokines |
| title_full_unstemmed | Advances in hydrogels for capturing and neutralizing inflammatory cytokines |
| title_short | Advances in hydrogels for capturing and neutralizing inflammatory cytokines |
| title_sort | advances in hydrogels for capturing and neutralizing inflammatory cytokines |
| url | https://doi.org/10.1177/20417314251342175 |
| work_keys_str_mv | AT hongweiqin advancesinhydrogelsforcapturingandneutralizinginflammatorycytokines AT zeli advancesinhydrogelsforcapturingandneutralizinginflammatorycytokines AT sichengli advancesinhydrogelsforcapturingandneutralizinginflammatorycytokines AT jinjianhuang advancesinhydrogelsforcapturingandneutralizinginflammatorycytokines AT jiananren advancesinhydrogelsforcapturingandneutralizinginflammatorycytokines AT xiuwenwu advancesinhydrogelsforcapturingandneutralizinginflammatorycytokines |