Long-Term Survivorship of Esophageal Cancer Patients Treated with Radical Intent
To investigate the recent trends in definitive management of esophageal cancer, the records of 138 consecutive patients treated with radical intent in a single institution between 1995 and 2003 were reviewed and analyzed. The median follow-up period was 5.7 years (range 1.1 to 10.4 years). Seventy-s...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2008/231878 |
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| author | Alex Agranovich Colleen E McGahan Anagha Gurjal |
| author_facet | Alex Agranovich Colleen E McGahan Anagha Gurjal |
| author_sort | Alex Agranovich |
| collection | DOAJ |
| description | To investigate the recent trends in definitive management of esophageal cancer, the records of 138 consecutive patients treated with radical intent in a single institution between 1995 and 2003 were reviewed and analyzed. The median follow-up period was 5.7 years (range 1.1 to 10.4 years). Seventy-seven patients were treated with radiation therapy (RT) only and 61 with combined regimens (CRT), in which RT was combined with either radical surgery or chemotherapy, or both. The overall survival of the entire cohort was 32% over two years and 20% over five years. The survivorship in the RT group was 17% over two years and 5% over five years. In the CRT group, 51% and 35% survived over two and five years, respectively. From all the potential prognostic factors examined by univariate and multivariate analyses, only male sex and use of CRT were strongly associated with better survivorship. There was no significant difference in the outcomes among the different regimens of CRT. Survivorship was not affected by the location or histology of the tumour, clinical stage, dose of RT or use of endoluminal brachytherapy in addition to external beam RT. There was a greater tendency to use RT only more often in older patients, but patient age did not affect survivorship. The proportion of patients treated with CRT did not change significantly over the last versus the first four years of the observed period. Combined regimens are undoubtedly superior to RT as a single modality. The long-term survivorship of patients in a subgroup of our patients treated with combined modality protocols compared favourably with the previously reported results in the literature and specifically in prospective randomized trials. However, the optimal combined modality regimen is yet to be defined. |
| format | Article |
| id | doaj-art-0a85140065fa4aa89f48efcd3628eebd |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
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| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-0a85140065fa4aa89f48efcd3628eebd2025-02-03T01:22:36ZengWileyCanadian Journal of Gastroenterology0835-79002008-01-0122439339810.1155/2008/231878Long-Term Survivorship of Esophageal Cancer Patients Treated with Radical IntentAlex Agranovich0Colleen E McGahan1Anagha Gurjal2Department of Radiation Oncology, British Columbia Cancer Agency, Fraser Valley Centre, Surrey, CanadaDepartment of Population and Preventive Oncology, British Columbia Cancer Agency, Vancouver Centre, Vancouver, CanadaDepartment of Medical Oncology, British Columbia Cancer Agency, Fraser Valley Centre, Surrey, British Columbia, CanadaTo investigate the recent trends in definitive management of esophageal cancer, the records of 138 consecutive patients treated with radical intent in a single institution between 1995 and 2003 were reviewed and analyzed. The median follow-up period was 5.7 years (range 1.1 to 10.4 years). Seventy-seven patients were treated with radiation therapy (RT) only and 61 with combined regimens (CRT), in which RT was combined with either radical surgery or chemotherapy, or both. The overall survival of the entire cohort was 32% over two years and 20% over five years. The survivorship in the RT group was 17% over two years and 5% over five years. In the CRT group, 51% and 35% survived over two and five years, respectively. From all the potential prognostic factors examined by univariate and multivariate analyses, only male sex and use of CRT were strongly associated with better survivorship. There was no significant difference in the outcomes among the different regimens of CRT. Survivorship was not affected by the location or histology of the tumour, clinical stage, dose of RT or use of endoluminal brachytherapy in addition to external beam RT. There was a greater tendency to use RT only more often in older patients, but patient age did not affect survivorship. The proportion of patients treated with CRT did not change significantly over the last versus the first four years of the observed period. Combined regimens are undoubtedly superior to RT as a single modality. The long-term survivorship of patients in a subgroup of our patients treated with combined modality protocols compared favourably with the previously reported results in the literature and specifically in prospective randomized trials. However, the optimal combined modality regimen is yet to be defined.http://dx.doi.org/10.1155/2008/231878 |
| spellingShingle | Alex Agranovich Colleen E McGahan Anagha Gurjal Long-Term Survivorship of Esophageal Cancer Patients Treated with Radical Intent Canadian Journal of Gastroenterology |
| title | Long-Term Survivorship of Esophageal Cancer Patients Treated with Radical Intent |
| title_full | Long-Term Survivorship of Esophageal Cancer Patients Treated with Radical Intent |
| title_fullStr | Long-Term Survivorship of Esophageal Cancer Patients Treated with Radical Intent |
| title_full_unstemmed | Long-Term Survivorship of Esophageal Cancer Patients Treated with Radical Intent |
| title_short | Long-Term Survivorship of Esophageal Cancer Patients Treated with Radical Intent |
| title_sort | long term survivorship of esophageal cancer patients treated with radical intent |
| url | http://dx.doi.org/10.1155/2008/231878 |
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