Plant-based Exosome Injections for Skin Wound Healing: Experimental Study
Background:. This study aimed to evaluate the impact of plant-derived exosome injections on the healing of skin wounds. Methods:. A total of 18 Wistar Albino rats were included and randomly allocated into 2 groups. The first group underwent a scalpel incision on the ventral hand surface without any...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2025-07-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006949 |
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| author | Noury Adel, MSc, DHM Nenad Stankovic, DDS Gerardo Cervantes, MD Amira Gindi, RNP Lamiaa Mohamed Shawky, PHD |
| author_facet | Noury Adel, MSc, DHM Nenad Stankovic, DDS Gerardo Cervantes, MD Amira Gindi, RNP Lamiaa Mohamed Shawky, PHD |
| author_sort | Noury Adel, MSc, DHM |
| collection | DOAJ |
| description | Background:. This study aimed to evaluate the impact of plant-derived exosome injections on the healing of skin wounds.
Methods:. A total of 18 Wistar Albino rats were included and randomly allocated into 2 groups. The first group underwent a scalpel incision on the ventral hand surface without any additional treatment. The second group received an identical incision, followed by injections of plant-based exosomes at the wound site. Tissue samples were collected at baseline, as well as on days 7 and 14, for histological assessment of wound healing. Hematoxylin and eosin and Masson trichrome staining were used to evaluate epithelial thickness, collagen deposition, and inflammatory cell infiltration.
Results:. The group receiving exosome injections exhibited a significantly enhanced wound healing response compared with the control group. Histological analysis revealed an increase in epithelial thickness, reduced inflammatory cell count, and greater collagen deposition with a more organized structural arrangement, indicating accelerated tissue repair. By day 14, wounds treated with exosomes demonstrated a well-formed epithelium and a substantial reduction in inflammation, highlighting the therapeutic potential of plant-derived exosomes in modulating wound healing dynamics.
Conclusions:. The administration of plant-based exosomes into skin wounds resulted in a notable improvement in the healing process. These findings suggest that exosome therapy may enhance tissue regeneration and expedite recovery, making it a promising approach for optimizing wound management and repair. Further research is warranted to explore its broader clinical applications. |
| format | Article |
| id | doaj-art-0a828f481c83482cb951b031e384f084 |
| institution | Kabale University |
| issn | 2169-7574 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj-art-0a828f481c83482cb951b031e384f0842025-08-26T03:24:18ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742025-07-01137e694910.1097/GOX.0000000000006949202507000-00025Plant-based Exosome Injections for Skin Wound Healing: Experimental StudyNoury Adel, MSc, DHM0Nenad Stankovic, DDS1Gerardo Cervantes, MD2Amira Gindi, RNP3Lamiaa Mohamed Shawky, PHD4* Oral and Maxillofacial Surgery Specialist, Private Practice, Cairo, Egypt† Private Practice, Belgrade, Serbia‡ Private Practice, Valencia, Spain§ Private Practice, Toronto, Canada¶ Department of Histology and Cell Biology, Benha Faculty of Medicine, Benha University, Benha, Egypt.Background:. This study aimed to evaluate the impact of plant-derived exosome injections on the healing of skin wounds. Methods:. A total of 18 Wistar Albino rats were included and randomly allocated into 2 groups. The first group underwent a scalpel incision on the ventral hand surface without any additional treatment. The second group received an identical incision, followed by injections of plant-based exosomes at the wound site. Tissue samples were collected at baseline, as well as on days 7 and 14, for histological assessment of wound healing. Hematoxylin and eosin and Masson trichrome staining were used to evaluate epithelial thickness, collagen deposition, and inflammatory cell infiltration. Results:. The group receiving exosome injections exhibited a significantly enhanced wound healing response compared with the control group. Histological analysis revealed an increase in epithelial thickness, reduced inflammatory cell count, and greater collagen deposition with a more organized structural arrangement, indicating accelerated tissue repair. By day 14, wounds treated with exosomes demonstrated a well-formed epithelium and a substantial reduction in inflammation, highlighting the therapeutic potential of plant-derived exosomes in modulating wound healing dynamics. Conclusions:. The administration of plant-based exosomes into skin wounds resulted in a notable improvement in the healing process. These findings suggest that exosome therapy may enhance tissue regeneration and expedite recovery, making it a promising approach for optimizing wound management and repair. Further research is warranted to explore its broader clinical applications.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006949 |
| spellingShingle | Noury Adel, MSc, DHM Nenad Stankovic, DDS Gerardo Cervantes, MD Amira Gindi, RNP Lamiaa Mohamed Shawky, PHD Plant-based Exosome Injections for Skin Wound Healing: Experimental Study Plastic and Reconstructive Surgery, Global Open |
| title | Plant-based Exosome Injections for Skin Wound Healing: Experimental Study |
| title_full | Plant-based Exosome Injections for Skin Wound Healing: Experimental Study |
| title_fullStr | Plant-based Exosome Injections for Skin Wound Healing: Experimental Study |
| title_full_unstemmed | Plant-based Exosome Injections for Skin Wound Healing: Experimental Study |
| title_short | Plant-based Exosome Injections for Skin Wound Healing: Experimental Study |
| title_sort | plant based exosome injections for skin wound healing experimental study |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006949 |
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