Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population

Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population

Abstract Background Keratoconus (KC) is a prevalent corneal condition with a modest genetic basis. Recent studies have reported significant genetic associations in multi-ethnic cohorts. However, the situation in the Chinese population remains unknown. This study was conducted to identify novel genet...

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Main Authors: Yinghao Yao, Xingyong Li, Lan Wu, Jia Zhang, Yuanyuan Gui, Xiangyi Yu, Yang Zhou, Xuefei Li, Xinyu Liu, Shilai Xing, Gang An, Zhenlin Du, Hui Liu, Shasha Li, Xiaoguang Yu, Myopia Associated Genetics Intervention and Consortiums, Hua Chen, Jianzhong Su, Shihao Chen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Eye and Vision
Subjects:
Keratoconus
Han Chinese
Whole-genome sequencing
Genome wide association analysis
Polygenic risk prediction
Online Access:https://doi.org/10.1186/s40662-024-00421-1
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