Quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography
Abstract Purpose Thyroid eye disease (TED) presents challenges in the accurate assessment of disease activity, especially concerning ocular surface manifestations. This study aims to evaluate the potential of anterior segment optical coherence tomography angiography (AS-OCTA) in quantifying vascular...
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BMC
2025-03-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-025-01627-y |
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| author | Ahmad Masoumi Pedram Afshar Hanieh Fakhredin Hamidreza Ghanbari Fateme Montazeri Amirhossein Aghajani Zahra Montazeriani Pezhman Pasyar Haniyeh Zeidabadinejad Faezeh Moghimpour Bijani Seyed Mohsen Rafizadeh |
| author_facet | Ahmad Masoumi Pedram Afshar Hanieh Fakhredin Hamidreza Ghanbari Fateme Montazeri Amirhossein Aghajani Zahra Montazeriani Pezhman Pasyar Haniyeh Zeidabadinejad Faezeh Moghimpour Bijani Seyed Mohsen Rafizadeh |
| author_sort | Ahmad Masoumi |
| collection | DOAJ |
| description | Abstract Purpose Thyroid eye disease (TED) presents challenges in the accurate assessment of disease activity, especially concerning ocular surface manifestations. This study aims to evaluate the potential of anterior segment optical coherence tomography angiography (AS-OCTA) in quantifying vascular changes associated with TED, thereby enhancing understanding of its pathophysiology and aiding in diagnosis and management. Methods We conducted a cross-sectional study involving 29 TED patients and 21 healthy controls. Participants underwent comprehensive ophthalmic examination and AS-OCTA imaging of predefined regions of interest (ROI) in the nasal and temporal quadrants. Vascular metrics including vessel density (VD), vessel length density (VLD), vessel diameter index (VDI) and fractal dimension (FD) were analyzed using AS-OCTA software. Disease activity was assessed using clinical activity scores (CAS). Results TED patients exhibited increased VD and VLD, particularly in the temporal quadrant, compared to healthy controls. Additionally, TED patients in active disease phases demonstrated larger VDI in the nasal quadrant. Negative correlations were observed between superficial VD and disease activity scores, while positive correlations were found between deep VDI and disease activity. Conclusion AS-OCTA demonstrates potential in quantitatively assessing vascular changes in TED, providing valuable insights into its pathophysiology and potential implications for clinical management. Conjunctival vascular parameters might be valuable in grading the TED disease activity in the future. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-0a7bf89cbb6a4ff58d65aa93243a0734 |
| institution | DOAJ |
| issn | 1471-2342 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj-art-0a7bf89cbb6a4ff58d65aa93243a07342025-08-20T03:01:39ZengBMCBMC Medical Imaging1471-23422025-03-0125111010.1186/s12880-025-01627-yQuantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiographyAhmad Masoumi0Pedram Afshar1Hanieh Fakhredin2Hamidreza Ghanbari3Fateme Montazeri4Amirhossein Aghajani5Zahra Montazeriani6Pezhman Pasyar7Haniyeh Zeidabadinejad8Faezeh Moghimpour Bijani9Seyed Mohsen Rafizadeh10Ophthalmology Department and Eye Research Center, Farabi Eye Hospital, School of Medicine, Tehran University of Medical SciencesOphthalmology Department and Eye Research Center, Farabi Eye Hospital, School of Medicine, Tehran University of Medical SciencesOphthalmology Department and Eye Research Center, Farabi Eye Hospital, School of Medicine, Tehran University of Medical SciencesOphthalmology Department and Eye Research Center, Farabi Eye Hospital, School of Medicine, Tehran University of Medical SciencesDepartment of Ophthalmology & Vision Science, Tschannen Eye Institute, University of California, DavisOphthalmology Department and Eye Research Center, Farabi Eye Hospital, School of Medicine, Tehran University of Medical SciencesDepartment of Medical Physics and Biomedical Engineering, Tehran University of Medical SciencesDepartment of Medical Physics and Biomedical Engineering, Tehran University of Medical SciencesOphthalmology Department and Eye Research Center, Farabi Eye Hospital, School of Medicine, Tehran University of Medical SciencesDepartment of Internal Medicine, School of Medicine, Shariati Hospital, Tehran University of Medical SciencesOphthalmology Department and Eye Research Center, Farabi Eye Hospital, School of Medicine, Tehran University of Medical SciencesAbstract Purpose Thyroid eye disease (TED) presents challenges in the accurate assessment of disease activity, especially concerning ocular surface manifestations. This study aims to evaluate the potential of anterior segment optical coherence tomography angiography (AS-OCTA) in quantifying vascular changes associated with TED, thereby enhancing understanding of its pathophysiology and aiding in diagnosis and management. Methods We conducted a cross-sectional study involving 29 TED patients and 21 healthy controls. Participants underwent comprehensive ophthalmic examination and AS-OCTA imaging of predefined regions of interest (ROI) in the nasal and temporal quadrants. Vascular metrics including vessel density (VD), vessel length density (VLD), vessel diameter index (VDI) and fractal dimension (FD) were analyzed using AS-OCTA software. Disease activity was assessed using clinical activity scores (CAS). Results TED patients exhibited increased VD and VLD, particularly in the temporal quadrant, compared to healthy controls. Additionally, TED patients in active disease phases demonstrated larger VDI in the nasal quadrant. Negative correlations were observed between superficial VD and disease activity scores, while positive correlations were found between deep VDI and disease activity. Conclusion AS-OCTA demonstrates potential in quantitatively assessing vascular changes in TED, providing valuable insights into its pathophysiology and potential implications for clinical management. Conjunctival vascular parameters might be valuable in grading the TED disease activity in the future. Clinical trial number Not applicable.https://doi.org/10.1186/s12880-025-01627-yTEDAS-OCTAConjunctivaTED activityCAS |
| spellingShingle | Ahmad Masoumi Pedram Afshar Hanieh Fakhredin Hamidreza Ghanbari Fateme Montazeri Amirhossein Aghajani Zahra Montazeriani Pezhman Pasyar Haniyeh Zeidabadinejad Faezeh Moghimpour Bijani Seyed Mohsen Rafizadeh Quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography BMC Medical Imaging TED AS-OCTA Conjunctiva TED activity CAS |
| title | Quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography |
| title_full | Quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography |
| title_fullStr | Quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography |
| title_full_unstemmed | Quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography |
| title_short | Quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography |
| title_sort | quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography |
| topic | TED AS-OCTA Conjunctiva TED activity CAS |
| url | https://doi.org/10.1186/s12880-025-01627-y |
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