Antibiofilm Activity of Fukoidans Isolated from Brown Algae
Biofilms play a significant role in the existence of bacteria under adverse conditions and the pathogenesis of infections. They contribute to the creation of reservoirs of antibiotic-resistant pathogens. This determines the relevance of the search for biologically active substances that inhibit the...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2024-01-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/1070 |
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| author | E. V. Matosova N. N. Besednova M. I. Kusaikin B. G. Andryukov I. D. Makarenkova M. Yu. Shchelkanov I. N. Lyapun M. P. Bynina S. P. Ermakova T. N. Zvyagintseva |
| author_facet | E. V. Matosova N. N. Besednova M. I. Kusaikin B. G. Andryukov I. D. Makarenkova M. Yu. Shchelkanov I. N. Lyapun M. P. Bynina S. P. Ermakova T. N. Zvyagintseva |
| author_sort | E. V. Matosova |
| collection | DOAJ |
| description | Biofilms play a significant role in the existence of bacteria under adverse conditions and the pathogenesis of infections. They contribute to the creation of reservoirs of antibiotic-resistant pathogens. This determines the relevance of the search for biologically active substances that inhibit the formation of biofilms. In recent years, the objects of intensive study are fucoidans — sulfated polysaccharides from marine brown algae, which have a wide polyfunctional spectrum of action. Their influence on the formation of Yersinia pseudotuberculosis biofilm in a dynamic model simulating the natural conditions of ecosystems of fucoidans belonging to different structural groups was investigated in this study. They are synthesized by brown algae: Fucus evanescens, Saccharina cichorioides, and Saccharina japonica. The fucoidan isolated from F.evanescens have showed the most pronounced antibiotic activity. The authors developed a new approach that allows obtaining stable results of multidirectional action of sulfated polysaccharides on the biofilm formation of Y.pseudotuberculosis. |
| format | Article |
| id | doaj-art-0a79040193ff46388c082c3ddf2cc38e |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-0a79040193ff46388c082c3ddf2cc38e2025-08-20T03:59:08ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902024-01-01689-1051110.37489/0235-2990-2023-68-9-10-5-11986Antibiofilm Activity of Fukoidans Isolated from Brown AlgaeE. V. Matosova0N. N. Besednova1M. I. Kusaikin2B. G. Andryukov3I. D. Makarenkova4M. Yu. Shchelkanov5I. N. Lyapun6M. P. Bynina7S. P. Ermakova8T. N. Zvyagintseva9G. P. Somov Research Institute of Epidemiology and Microbiology of the Federal Service for Surveillance on Consumer Rights Protection and Human WellbeingG. P. Somov Research Institute of Epidemiology and Microbiology of the Federal Service for Surveillance on Consumer Rights Protection and Human WellbeingG.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of SciencesG. P. Somov Research Institute of Epidemiology and Microbiology of the Federal Service for Surveillance on Consumer Rights Protection and Human WellbeingG. P. Somov Research Institute of Epidemiology and Microbiology of the Federal Service for Surveillance on Consumer Rights Protection and Human WellbeingG. P. Somov Research Institute of Epidemiology and Microbiology of the Federal Service for Surveillance on Consumer Rights Protection and Human WellbeingG. P. Somov Research Institute of Epidemiology and Microbiology of the Federal Service for Surveillance on Consumer Rights Protection and Human WellbeingG. P. Somov Research Institute of Epidemiology and Microbiology of the Federal Service for Surveillance on Consumer Rights Protection and Human WellbeingG.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of SciencesG.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of SciencesBiofilms play a significant role in the existence of bacteria under adverse conditions and the pathogenesis of infections. They contribute to the creation of reservoirs of antibiotic-resistant pathogens. This determines the relevance of the search for biologically active substances that inhibit the formation of biofilms. In recent years, the objects of intensive study are fucoidans — sulfated polysaccharides from marine brown algae, which have a wide polyfunctional spectrum of action. Their influence on the formation of Yersinia pseudotuberculosis biofilm in a dynamic model simulating the natural conditions of ecosystems of fucoidans belonging to different structural groups was investigated in this study. They are synthesized by brown algae: Fucus evanescens, Saccharina cichorioides, and Saccharina japonica. The fucoidan isolated from F.evanescens have showed the most pronounced antibiotic activity. The authors developed a new approach that allows obtaining stable results of multidirectional action of sulfated polysaccharides on the biofilm formation of Y.pseudotuberculosis.https://www.antibiotics-chemotherapy.ru/jour/article/view/1070biofilms, yersinia pseudotuberculosis, inhibition, fucoidans (sulfated polysaccharides), brown algae |
| spellingShingle | E. V. Matosova N. N. Besednova M. I. Kusaikin B. G. Andryukov I. D. Makarenkova M. Yu. Shchelkanov I. N. Lyapun M. P. Bynina S. P. Ermakova T. N. Zvyagintseva Antibiofilm Activity of Fukoidans Isolated from Brown Algae Антибиотики и Химиотерапия biofilms, yersinia pseudotuberculosis, inhibition, fucoidans (sulfated polysaccharides), brown algae |
| title | Antibiofilm Activity of Fukoidans Isolated from Brown Algae |
| title_full | Antibiofilm Activity of Fukoidans Isolated from Brown Algae |
| title_fullStr | Antibiofilm Activity of Fukoidans Isolated from Brown Algae |
| title_full_unstemmed | Antibiofilm Activity of Fukoidans Isolated from Brown Algae |
| title_short | Antibiofilm Activity of Fukoidans Isolated from Brown Algae |
| title_sort | antibiofilm activity of fukoidans isolated from brown algae |
| topic | biofilms, yersinia pseudotuberculosis, inhibition, fucoidans (sulfated polysaccharides), brown algae |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/1070 |
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