Kidney damage on fertility and pregnancy: A Mendelian randomization.
<h4>Background</h4>Low fertility and adverse pregnancy outcomes are commonly observed in women with chronic kidney disease (CKD). However, a causal relationship between low fertility and adverse pregnancy outcomes with CKD remains unclear. Besides, whether mild kidney dysfunction can aff...
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Public Library of Science (PLoS)
2023-01-01
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| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288788&type=printable |
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| author | Jin Ren Qiuyan Huang Xiaowei Lie Xingli Tong Qi Yao Ge Zhou |
| author_facet | Jin Ren Qiuyan Huang Xiaowei Lie Xingli Tong Qi Yao Ge Zhou |
| author_sort | Jin Ren |
| collection | DOAJ |
| description | <h4>Background</h4>Low fertility and adverse pregnancy outcomes are commonly observed in women with chronic kidney disease (CKD). However, a causal relationship between low fertility and adverse pregnancy outcomes with CKD remains unclear. Besides, whether mild kidney dysfunction can affect fertility and pregnancy still needs exploration. Hence, this study aimed to investigate the causal effect of kidney damage on fertility and pregnancy using Mendelian randomization (MR).<h4>Methods</h4>We first used two-sample MR to examine the effects of kidney damage on fertility and pregnancy. Next, we introduced the Bayesian model averaging MR analysis to detect major causal relationships and render the results robust. The genetic instruments and outcome data were derived from various large genome-wide association studies.<h4>Results</h4>Adverse pregnancy outcomes: Our analyses supported a suggestive causal effect of CKD and estimated glomerular filtration rate (eGFR) rapid on stillbirth, with CKD having an odds ratio (OR) of 1.020 [95% confidence interval (CI) 1.002 to 1.038] and eGFR rapid having an OR of 1.026 (95% CI 1.004-1.048). We also discovered a suggestive causal effect of eGFR on spontaneous abortion, with an OR of 2.63 (95% CI 1.269 to 5.450). Moreover, increased urinary albumin-to-creatinine ratio (UACR) was regarded as a potential risk factor for pre-eclampsia (OR = 1.936; 95% CI 1.065 to 3.517) and gestational hypertension (OR = 1.700; 95% CI 1.002 to 2.886). Fertility assessment: The results indicated that eGFR and UACR had a suggestive causal relationship with the anti-Müllerian hormone level (eGFR beta: 1.004; UACR beta: 0.405).<h4>Conclusions</h4>Our study used MR to demonstrate a suggestive causal relationship between kidney damage and fertility and pregnancy. We reported that mild kidney dysfunction might be a risk factor for reduced fertility and adverse pregnancy outcomes. Dynamic renal detection may help preserve fertility and reduce the risk of pregnancy loss. |
| format | Article |
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| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-0a77a514d9ce4cfca87f7cf4504c6b002025-02-05T05:32:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01187e028878810.1371/journal.pone.0288788Kidney damage on fertility and pregnancy: A Mendelian randomization.Jin RenQiuyan HuangXiaowei LieXingli TongQi YaoGe Zhou<h4>Background</h4>Low fertility and adverse pregnancy outcomes are commonly observed in women with chronic kidney disease (CKD). However, a causal relationship between low fertility and adverse pregnancy outcomes with CKD remains unclear. Besides, whether mild kidney dysfunction can affect fertility and pregnancy still needs exploration. Hence, this study aimed to investigate the causal effect of kidney damage on fertility and pregnancy using Mendelian randomization (MR).<h4>Methods</h4>We first used two-sample MR to examine the effects of kidney damage on fertility and pregnancy. Next, we introduced the Bayesian model averaging MR analysis to detect major causal relationships and render the results robust. The genetic instruments and outcome data were derived from various large genome-wide association studies.<h4>Results</h4>Adverse pregnancy outcomes: Our analyses supported a suggestive causal effect of CKD and estimated glomerular filtration rate (eGFR) rapid on stillbirth, with CKD having an odds ratio (OR) of 1.020 [95% confidence interval (CI) 1.002 to 1.038] and eGFR rapid having an OR of 1.026 (95% CI 1.004-1.048). We also discovered a suggestive causal effect of eGFR on spontaneous abortion, with an OR of 2.63 (95% CI 1.269 to 5.450). Moreover, increased urinary albumin-to-creatinine ratio (UACR) was regarded as a potential risk factor for pre-eclampsia (OR = 1.936; 95% CI 1.065 to 3.517) and gestational hypertension (OR = 1.700; 95% CI 1.002 to 2.886). Fertility assessment: The results indicated that eGFR and UACR had a suggestive causal relationship with the anti-Müllerian hormone level (eGFR beta: 1.004; UACR beta: 0.405).<h4>Conclusions</h4>Our study used MR to demonstrate a suggestive causal relationship between kidney damage and fertility and pregnancy. We reported that mild kidney dysfunction might be a risk factor for reduced fertility and adverse pregnancy outcomes. Dynamic renal detection may help preserve fertility and reduce the risk of pregnancy loss.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288788&type=printable |
| spellingShingle | Jin Ren Qiuyan Huang Xiaowei Lie Xingli Tong Qi Yao Ge Zhou Kidney damage on fertility and pregnancy: A Mendelian randomization. PLoS ONE |
| title | Kidney damage on fertility and pregnancy: A Mendelian randomization. |
| title_full | Kidney damage on fertility and pregnancy: A Mendelian randomization. |
| title_fullStr | Kidney damage on fertility and pregnancy: A Mendelian randomization. |
| title_full_unstemmed | Kidney damage on fertility and pregnancy: A Mendelian randomization. |
| title_short | Kidney damage on fertility and pregnancy: A Mendelian randomization. |
| title_sort | kidney damage on fertility and pregnancy a mendelian randomization |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288788&type=printable |
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