Pre- and post-diagnosis dietary patterns and overall survival in patients with epithelial ovarian cancer: a prospective cohort study
Abstract Background Previous studies have examined the associations between individual foods or nutrients, but few studies have considered dietary patterns associated with ovarian cancer (OC) survival. Methods In a prospective cohort study, we examined the association between pre-diagnosis and post-...
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BMC
2025-02-01
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| Online Access: | https://doi.org/10.1186/s12885-025-13610-5 |
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| author | Ying Qin Xi-Yang Chen Fan Cao Jia-Cheng Liu Lang Wu Fang-Hua Liu Yi-Zi Li He-Li Xu Yi-Fan Wei Dong-Hui Huang Xiao-Ying Li Qian Xiao Song Gao Qi-Peng Ma Lei Wang Ting-Ting Gong Qi-Jun Wu |
| author_facet | Ying Qin Xi-Yang Chen Fan Cao Jia-Cheng Liu Lang Wu Fang-Hua Liu Yi-Zi Li He-Li Xu Yi-Fan Wei Dong-Hui Huang Xiao-Ying Li Qian Xiao Song Gao Qi-Peng Ma Lei Wang Ting-Ting Gong Qi-Jun Wu |
| author_sort | Ying Qin |
| collection | DOAJ |
| description | Abstract Background Previous studies have examined the associations between individual foods or nutrients, but few studies have considered dietary patterns associated with ovarian cancer (OC) survival. Methods In a prospective cohort study, we examined the association between pre-diagnosis and post-diagnosis overall diet, including changes from pre-diagnosis to post-diagnosis, and overall survival (OS) in 560 patients with OC. Dietary intake was collected using a valid 111-item food frequency questionnaire. Principal component analysis was performed to determine the dietary patterns. Cox proportional hazard regression models were used to assess the hazard ratio (HRs) and 95% confidence interval (CIs). Results Two dietary patterns were identified: Balanced and nutritious pattern and Energy-dense pattern. The highest tertile of the post-diagnosis Balanced and nutritious pattern scores was related to better OS compared with the lowest tertile (HR = 0.40, 95% CI = 0.17–0.95, P trend < 0.05). However, no significant association between pre-diagnosis and post-diagnosis Energy-dense pattern scores and OS was observed. Compared to those who had persistently high Balanced and nutritious pattern scores, patients who changed from a high score of pre-diagnosis Balanced and nutritious pattern to low post-diagnosis, as well as those who shifted from a low to a high score, both had a decreased OS (HRhigh−low vs. high−high = 1.91, 95% CI = 1.18–3.08; HRlow−high vs. high−high = 2.19, 95% CI = 1.24–3.86). Additionally, patients who changed from a high pre-diagnosis score to a low post-diagnosis score had a decreased OS compared to those with consistently low Energy-dense pattern scores (HRhigh−low vs. low−low = 1.74, 95% CI = 1.06–2.84). Conclusions Greater adherence to the Balanced and nutritious pattern as well as less adherence to the Energy-dense pattern from pre-diagnosis to post-diagnosis were associated with better OC survival. |
| format | Article |
| id | doaj-art-0a7198efc4334490acfdc683380befed |
| institution | DOAJ |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-0a7198efc4334490acfdc683380befed2025-08-20T02:59:32ZengBMCBMC Cancer1471-24072025-02-0125111210.1186/s12885-025-13610-5Pre- and post-diagnosis dietary patterns and overall survival in patients with epithelial ovarian cancer: a prospective cohort studyYing Qin0Xi-Yang Chen1Fan Cao2Jia-Cheng Liu3Lang Wu4Fang-Hua Liu5Yi-Zi Li6He-Li Xu7Yi-Fan Wei8Dong-Hui Huang9Xiao-Ying Li10Qian Xiao11Song Gao12Qi-Peng Ma13Lei Wang14Ting-Ting Gong15Qi-Jun Wu16Department of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityCancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at ManoaDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityAbstract Background Previous studies have examined the associations between individual foods or nutrients, but few studies have considered dietary patterns associated with ovarian cancer (OC) survival. Methods In a prospective cohort study, we examined the association between pre-diagnosis and post-diagnosis overall diet, including changes from pre-diagnosis to post-diagnosis, and overall survival (OS) in 560 patients with OC. Dietary intake was collected using a valid 111-item food frequency questionnaire. Principal component analysis was performed to determine the dietary patterns. Cox proportional hazard regression models were used to assess the hazard ratio (HRs) and 95% confidence interval (CIs). Results Two dietary patterns were identified: Balanced and nutritious pattern and Energy-dense pattern. The highest tertile of the post-diagnosis Balanced and nutritious pattern scores was related to better OS compared with the lowest tertile (HR = 0.40, 95% CI = 0.17–0.95, P trend < 0.05). However, no significant association between pre-diagnosis and post-diagnosis Energy-dense pattern scores and OS was observed. Compared to those who had persistently high Balanced and nutritious pattern scores, patients who changed from a high score of pre-diagnosis Balanced and nutritious pattern to low post-diagnosis, as well as those who shifted from a low to a high score, both had a decreased OS (HRhigh−low vs. high−high = 1.91, 95% CI = 1.18–3.08; HRlow−high vs. high−high = 2.19, 95% CI = 1.24–3.86). Additionally, patients who changed from a high pre-diagnosis score to a low post-diagnosis score had a decreased OS compared to those with consistently low Energy-dense pattern scores (HRhigh−low vs. low−low = 1.74, 95% CI = 1.06–2.84). Conclusions Greater adherence to the Balanced and nutritious pattern as well as less adherence to the Energy-dense pattern from pre-diagnosis to post-diagnosis were associated with better OC survival.https://doi.org/10.1186/s12885-025-13610-5CohortDietary patternOvarian cancerPrincipal component analysisSurvival |
| spellingShingle | Ying Qin Xi-Yang Chen Fan Cao Jia-Cheng Liu Lang Wu Fang-Hua Liu Yi-Zi Li He-Li Xu Yi-Fan Wei Dong-Hui Huang Xiao-Ying Li Qian Xiao Song Gao Qi-Peng Ma Lei Wang Ting-Ting Gong Qi-Jun Wu Pre- and post-diagnosis dietary patterns and overall survival in patients with epithelial ovarian cancer: a prospective cohort study BMC Cancer Cohort Dietary pattern Ovarian cancer Principal component analysis Survival |
| title | Pre- and post-diagnosis dietary patterns and overall survival in patients with epithelial ovarian cancer: a prospective cohort study |
| title_full | Pre- and post-diagnosis dietary patterns and overall survival in patients with epithelial ovarian cancer: a prospective cohort study |
| title_fullStr | Pre- and post-diagnosis dietary patterns and overall survival in patients with epithelial ovarian cancer: a prospective cohort study |
| title_full_unstemmed | Pre- and post-diagnosis dietary patterns and overall survival in patients with epithelial ovarian cancer: a prospective cohort study |
| title_short | Pre- and post-diagnosis dietary patterns and overall survival in patients with epithelial ovarian cancer: a prospective cohort study |
| title_sort | pre and post diagnosis dietary patterns and overall survival in patients with epithelial ovarian cancer a prospective cohort study |
| topic | Cohort Dietary pattern Ovarian cancer Principal component analysis Survival |
| url | https://doi.org/10.1186/s12885-025-13610-5 |
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