Association of the vitamin D receptor gene polymorphism with sex- and non-sex-associated cancers: A meta-analysis
Currently higher morbidity and mortality rates are observed in cancer diseases, especially sex-dependent cancers. A positive role of endogenous vitamin D concentration in cancer diseases has been reported in many publications. Furthermore, there has been observed a relationship between serum vitamin...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-10-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317727164 |
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| _version_ | 1849707020692750336 |
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| author | Lukasz Laczmanski Felicja Lwow Anna Osina Martyna Kepska Izabela Laczmanska Wojciech Witkiewicz |
| author_facet | Lukasz Laczmanski Felicja Lwow Anna Osina Martyna Kepska Izabela Laczmanska Wojciech Witkiewicz |
| author_sort | Lukasz Laczmanski |
| collection | DOAJ |
| description | Currently higher morbidity and mortality rates are observed in cancer diseases, especially sex-dependent cancers. A positive role of endogenous vitamin D concentration in cancer diseases has been reported in many publications. Furthermore, there has been observed a relationship between serum vitamin D and testosterone concentrations in an elderly Caucasian population carrying the vitamin D receptor FokI gene polymorphism. The aim of this study was to investigate whether the vitamin D receptor FokI polymorphism is associated with cancerogenesis in sex-dependent cancers. The MEDLINE and ResearchGate databases were used to search for articles up to January 2017, and 96 articles concerning the FokI polymorphism were chosen. Odds ratios with 95% confidence intervals were used to assess the strength of associations between polymorphisms of vitamin D receptor and cancer risk in the described populations. The fixed-effects model and the DerSimonian–Laird random-effects model (with weights based on the inverse variance) were used to calculate summary odds ratios, and both within- and between-study variation were considered. Generally, the F variant reduces the risk of cancer by 4% (odds ratio = 0.96, p value = 0.0057). This effect is particularly evident in female sex–associated cancers (odds ratio = 0.96, 95% confidence interval: 0.93–0.99, p value = 0.0259), but it is not observed in non-sex-associated cancers. Polymorphism FokI is associated with breast and ovarian cancers. |
| format | Article |
| id | doaj-art-0a71230ee5c24900b4ea8acf0ca86fab |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-0a71230ee5c24900b4ea8acf0ca86fab2025-08-20T03:16:02ZengSAGE PublishingTumor Biology1423-03802017-10-013910.1177/1010428317727164Association of the vitamin D receptor gene polymorphism with sex- and non-sex-associated cancers: A meta-analysisLukasz Laczmanski0Felicja Lwow1Anna Osina2Martyna Kepska3Izabela Laczmanska4Wojciech Witkiewicz5Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, PolandDepartment of Health Promotion, Faculty of Physiotherapy, University School of Physical Education, Wroclaw, PolandHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, PolandHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, PolandGenetic Department, Wroclaw Medical University, Wroclaw, PolandResearch and Development Center of Lower Silesian Regional Specialist Hospital, Wroclaw, PolandCurrently higher morbidity and mortality rates are observed in cancer diseases, especially sex-dependent cancers. A positive role of endogenous vitamin D concentration in cancer diseases has been reported in many publications. Furthermore, there has been observed a relationship between serum vitamin D and testosterone concentrations in an elderly Caucasian population carrying the vitamin D receptor FokI gene polymorphism. The aim of this study was to investigate whether the vitamin D receptor FokI polymorphism is associated with cancerogenesis in sex-dependent cancers. The MEDLINE and ResearchGate databases were used to search for articles up to January 2017, and 96 articles concerning the FokI polymorphism were chosen. Odds ratios with 95% confidence intervals were used to assess the strength of associations between polymorphisms of vitamin D receptor and cancer risk in the described populations. The fixed-effects model and the DerSimonian–Laird random-effects model (with weights based on the inverse variance) were used to calculate summary odds ratios, and both within- and between-study variation were considered. Generally, the F variant reduces the risk of cancer by 4% (odds ratio = 0.96, p value = 0.0057). This effect is particularly evident in female sex–associated cancers (odds ratio = 0.96, 95% confidence interval: 0.93–0.99, p value = 0.0259), but it is not observed in non-sex-associated cancers. Polymorphism FokI is associated with breast and ovarian cancers.https://doi.org/10.1177/1010428317727164 |
| spellingShingle | Lukasz Laczmanski Felicja Lwow Anna Osina Martyna Kepska Izabela Laczmanska Wojciech Witkiewicz Association of the vitamin D receptor gene polymorphism with sex- and non-sex-associated cancers: A meta-analysis Tumor Biology |
| title | Association of the vitamin D receptor gene polymorphism with sex- and non-sex-associated cancers: A meta-analysis |
| title_full | Association of the vitamin D receptor gene polymorphism with sex- and non-sex-associated cancers: A meta-analysis |
| title_fullStr | Association of the vitamin D receptor gene polymorphism with sex- and non-sex-associated cancers: A meta-analysis |
| title_full_unstemmed | Association of the vitamin D receptor gene polymorphism with sex- and non-sex-associated cancers: A meta-analysis |
| title_short | Association of the vitamin D receptor gene polymorphism with sex- and non-sex-associated cancers: A meta-analysis |
| title_sort | association of the vitamin d receptor gene polymorphism with sex and non sex associated cancers a meta analysis |
| url | https://doi.org/10.1177/1010428317727164 |
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