BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription

BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription

Abstract The persistence of HIV-1 in a latent state within long-lived immune cells remains a major barrier to a cure for HIV-1 infection. The “block-and-lock” strategy aims to silence the HIV-1 provirus permanently using latency promoting agents (LPAs). LEDGINs, a well-known class of LPAs, inhibit t...

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Bibliographic Details
Main Authors: Eline Pellaers, Julie Janssens, Lore Wils, Alexe Denis, Anayat Bhat, Siska Van Belle, Da Feng, Frauke Christ, Peng Zhan, Zeger Debyser
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59398-7
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