Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis
We conducted a meta-analysis to comprehensively evaluate the correlations of ezrin expression with pathological characteristics and the prognosis of osteosarcoma. The MEDLINE (1966–2013), the Cochrane Library Database, EMBASE, CINAHL, Web of Science (1945–2013), and the Chinese Biomedical Database w...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/837543 |
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| author | Da-Hang Zhao Jiang Zhu Wen-Bo Wang Feng Dong Qiao Zhang Hong-Wu Fan Jing-Zhe Zhang Yong-Ming Wang |
| author_facet | Da-Hang Zhao Jiang Zhu Wen-Bo Wang Feng Dong Qiao Zhang Hong-Wu Fan Jing-Zhe Zhang Yong-Ming Wang |
| author_sort | Da-Hang Zhao |
| collection | DOAJ |
| description | We conducted a meta-analysis to comprehensively evaluate the correlations of ezrin expression with pathological characteristics and the prognosis of osteosarcoma. The MEDLINE (1966–2013), the Cochrane Library Database, EMBASE, CINAHL, Web of Science (1945–2013), and the Chinese Biomedical Database were searched without language restrictions. Meta-analyses conducted using STATA software were calculated. Ten studies met the inclusion criteria, including 459 patients with osteosarcoma. Meta-analysis results illustrated that ezrin expression may be closely associated with the recurrence of osteosarcoma or metastasis in osteosarcoma. Our findings also demonstrated that patients with grade III-IV osteosarcoma showed a higher frequency of ezrin expression than those with histological grade I-II osteosarcoma. Furthermore, we found that patients with positive expression of ezrin exhibited a shorter overall survival than those with negative ezrin expression. The results also indicated that positive ezrin expression was strongly correlated with poorer metastasis-free survival. Nevertheless, no significant relationships were observed between ezrin expression and clinical variables (age and gender). In the current meta-analysis, our results illustrated significant relationships of ezrin expression with pathological characteristics and prognosis of osteosarcoma. Thus, ezrin expression could be a promising marker in predicting the clinical outcome of patients with osteosarcoma. |
| format | Article |
| id | doaj-art-0a5d7978c7a844658dd52b9dfefcc9ee |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0a5d7978c7a844658dd52b9dfefcc9ee2025-08-20T03:55:27ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/837543837543Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-AnalysisDa-Hang Zhao0Jiang Zhu1Wen-Bo Wang2Feng Dong3Qiao Zhang4Hong-Wu Fan5Jing-Zhe Zhang6Yong-Ming Wang73rd Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001, China3rd Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001, China3rd Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001, China4th Department of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, ChinaDepartment of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, ChinaDepartment of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, ChinaDepartment of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, ChinaDepartment of Orthopedics, China Japan Union Hospital of Jilin University, Changchun 130033, ChinaWe conducted a meta-analysis to comprehensively evaluate the correlations of ezrin expression with pathological characteristics and the prognosis of osteosarcoma. The MEDLINE (1966–2013), the Cochrane Library Database, EMBASE, CINAHL, Web of Science (1945–2013), and the Chinese Biomedical Database were searched without language restrictions. Meta-analyses conducted using STATA software were calculated. Ten studies met the inclusion criteria, including 459 patients with osteosarcoma. Meta-analysis results illustrated that ezrin expression may be closely associated with the recurrence of osteosarcoma or metastasis in osteosarcoma. Our findings also demonstrated that patients with grade III-IV osteosarcoma showed a higher frequency of ezrin expression than those with histological grade I-II osteosarcoma. Furthermore, we found that patients with positive expression of ezrin exhibited a shorter overall survival than those with negative ezrin expression. The results also indicated that positive ezrin expression was strongly correlated with poorer metastasis-free survival. Nevertheless, no significant relationships were observed between ezrin expression and clinical variables (age and gender). In the current meta-analysis, our results illustrated significant relationships of ezrin expression with pathological characteristics and prognosis of osteosarcoma. Thus, ezrin expression could be a promising marker in predicting the clinical outcome of patients with osteosarcoma.http://dx.doi.org/10.1155/2014/837543 |
| spellingShingle | Da-Hang Zhao Jiang Zhu Wen-Bo Wang Feng Dong Qiao Zhang Hong-Wu Fan Jing-Zhe Zhang Yong-Ming Wang Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis The Scientific World Journal |
| title | Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis |
| title_full | Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis |
| title_fullStr | Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis |
| title_full_unstemmed | Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis |
| title_short | Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis |
| title_sort | correlations of ezrin expression with pathological characteristics and prognosis of osteosarcoma a meta analysis |
| url | http://dx.doi.org/10.1155/2014/837543 |
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