Metastatic Merkel Cell Carcinoma Masquerading as Multiple Immune-Related Adverse Events
Merkel cell carcinoma is a rare cutaneous neuroendocrine carcinoma with a high rate of regional and distant metastasis and mortality. Here, we report a novel case of Merkel cell carcinoma which presented as a primary lesion to the left cheek with regional lymph node involvement and was treated with...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/8890845 |
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| author | Farees Saqlain Sophia Z. Shalhout Kevin S. Emerick Tomas G. Neilan Tatyana Sharova David Michael Miller |
| author_facet | Farees Saqlain Sophia Z. Shalhout Kevin S. Emerick Tomas G. Neilan Tatyana Sharova David Michael Miller |
| author_sort | Farees Saqlain |
| collection | DOAJ |
| description | Merkel cell carcinoma is a rare cutaneous neuroendocrine carcinoma with a high rate of regional and distant metastasis and mortality. Here, we report a novel case of Merkel cell carcinoma which presented as a primary lesion to the left cheek with regional lymph node involvement and was treated with pembrolizumab and radiation. Widely metastatic disease eventually revealed on autopsy clinically mimicked immune-related organ insult leading to management with immunosuppressants. The patient also had a biopsy-confirmed immune-related cutaneous adverse event during admission. The case highlights a rare circumstance in which disease progression masqueraded as multiple immune-related end-organ adverse events. Contribution of on-target anti-PD-1 toxicity remains a possibility. |
| format | Article |
| id | doaj-art-0a5d355a04f84e94badc9ecd57ea0d00 |
| institution | OA Journals |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-0a5d355a04f84e94badc9ecd57ea0d002025-08-20T02:03:12ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712020-01-01202010.1155/2020/88908458890845Metastatic Merkel Cell Carcinoma Masquerading as Multiple Immune-Related Adverse EventsFarees Saqlain0Sophia Z. Shalhout1Kevin S. Emerick2Tomas G. Neilan3Tatyana Sharova4David Michael Miller5Harvard Medical School, Boston, MA, USAHarvard Medical School, Boston, MA, USAHarvard Medical School, Boston, MA, USAHarvard Medical School, Boston, MA, USADepartment of Medicine, Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA, USAHarvard Medical School, Boston, MA, USAMerkel cell carcinoma is a rare cutaneous neuroendocrine carcinoma with a high rate of regional and distant metastasis and mortality. Here, we report a novel case of Merkel cell carcinoma which presented as a primary lesion to the left cheek with regional lymph node involvement and was treated with pembrolizumab and radiation. Widely metastatic disease eventually revealed on autopsy clinically mimicked immune-related organ insult leading to management with immunosuppressants. The patient also had a biopsy-confirmed immune-related cutaneous adverse event during admission. The case highlights a rare circumstance in which disease progression masqueraded as multiple immune-related end-organ adverse events. Contribution of on-target anti-PD-1 toxicity remains a possibility.http://dx.doi.org/10.1155/2020/8890845 |
| spellingShingle | Farees Saqlain Sophia Z. Shalhout Kevin S. Emerick Tomas G. Neilan Tatyana Sharova David Michael Miller Metastatic Merkel Cell Carcinoma Masquerading as Multiple Immune-Related Adverse Events Case Reports in Dermatological Medicine |
| title | Metastatic Merkel Cell Carcinoma Masquerading as Multiple Immune-Related Adverse Events |
| title_full | Metastatic Merkel Cell Carcinoma Masquerading as Multiple Immune-Related Adverse Events |
| title_fullStr | Metastatic Merkel Cell Carcinoma Masquerading as Multiple Immune-Related Adverse Events |
| title_full_unstemmed | Metastatic Merkel Cell Carcinoma Masquerading as Multiple Immune-Related Adverse Events |
| title_short | Metastatic Merkel Cell Carcinoma Masquerading as Multiple Immune-Related Adverse Events |
| title_sort | metastatic merkel cell carcinoma masquerading as multiple immune related adverse events |
| url | http://dx.doi.org/10.1155/2020/8890845 |
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