TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine
In the present study, electrochemical behavior of nevirapine on a glassy carbon electrode (GCE) modified with TiO2 nanoparticles decorated graphene nanoribbons was investigated. Characterization of different components used for modifications was achieved using Fourier transform infrared spectroscopy...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/3932715 |
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| _version_ | 1849305485307543552 |
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| author | Daniel Apath Mambo Moyo Munyaradzi Shumba |
| author_facet | Daniel Apath Mambo Moyo Munyaradzi Shumba |
| author_sort | Daniel Apath |
| collection | DOAJ |
| description | In the present study, electrochemical behavior of nevirapine on a glassy carbon electrode (GCE) modified with TiO2 nanoparticles decorated graphene nanoribbons was investigated. Characterization of different components used for modifications was achieved using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The electrochemical behavior of nevirapine on the modified electrodes was examined using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), chronoamperometry (CA), and differential pulse voltammetry (DPV). A considerable oxidation potential decrease of +352 mV for nevirapine in 0.1 M phosphate-buffered saline (PBS), pH 11.0, was achieved due to synergy offered by graphene nanoribbons and TiO2 compared to graphene nanoribbons (+252 mV) and TiO2 (−37 mV), all with respect to the glassy carbon electrode. Under optimized conditions, DPV gave linear calibrations over the range of 0.020–0.14 µM. The detection limit was calculated as 0.043 µM. The developed sensor was used for determination of nevirapine in a pharmaceutical formulation successfully. |
| format | Article |
| id | doaj-art-0a5b28daaabc41818006ba9fef46bc04 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-0a5b28daaabc41818006ba9fef46bc042025-08-20T03:55:27ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/39327153932715TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug NevirapineDaniel Apath0Mambo Moyo1Munyaradzi Shumba2Sensor Lab Research Group, Department of Chemical Technology, Midlands State University, Private Bag 9055 Senga, Gweru, ZimbabweSensor Lab Research Group, Department of Chemical Technology, Midlands State University, Private Bag 9055 Senga, Gweru, ZimbabweSensor Lab Research Group, Department of Chemical Technology, Midlands State University, Private Bag 9055 Senga, Gweru, ZimbabweIn the present study, electrochemical behavior of nevirapine on a glassy carbon electrode (GCE) modified with TiO2 nanoparticles decorated graphene nanoribbons was investigated. Characterization of different components used for modifications was achieved using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The electrochemical behavior of nevirapine on the modified electrodes was examined using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), chronoamperometry (CA), and differential pulse voltammetry (DPV). A considerable oxidation potential decrease of +352 mV for nevirapine in 0.1 M phosphate-buffered saline (PBS), pH 11.0, was achieved due to synergy offered by graphene nanoribbons and TiO2 compared to graphene nanoribbons (+252 mV) and TiO2 (−37 mV), all with respect to the glassy carbon electrode. Under optimized conditions, DPV gave linear calibrations over the range of 0.020–0.14 µM. The detection limit was calculated as 0.043 µM. The developed sensor was used for determination of nevirapine in a pharmaceutical formulation successfully.http://dx.doi.org/10.1155/2020/3932715 |
| spellingShingle | Daniel Apath Mambo Moyo Munyaradzi Shumba TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine Journal of Chemistry |
| title | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine |
| title_full | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine |
| title_fullStr | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine |
| title_full_unstemmed | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine |
| title_short | TiO2 Nanoparticles Decorated Graphene Nanoribbons for Voltammetric Determination of an Anti-HIV Drug Nevirapine |
| title_sort | tio2 nanoparticles decorated graphene nanoribbons for voltammetric determination of an anti hiv drug nevirapine |
| url | http://dx.doi.org/10.1155/2020/3932715 |
| work_keys_str_mv | AT danielapath tio2nanoparticlesdecoratedgraphenenanoribbonsforvoltammetricdeterminationofanantihivdrugnevirapine AT mambomoyo tio2nanoparticlesdecoratedgraphenenanoribbonsforvoltammetricdeterminationofanantihivdrugnevirapine AT munyaradzishumba tio2nanoparticlesdecoratedgraphenenanoribbonsforvoltammetricdeterminationofanantihivdrugnevirapine |