Engineering silk-based biomaterials: Extraction, modification, and reprocessing strategies in biomedical applications
Natural silk, renowned for its remarkable mechanical properties, biocompatibility, degradability, and scalability in production, has become a promising biomaterial for regenerative medicine. Recent advances in silk chemistry and biomaterials engineering have enabled functional modifications of silk...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127525004460 |
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| author | Zhaoyang Wang Haixia Chen Jing Yang Xin Du Linbao Zhu Xiao Xu Guangdong Sun Xiuling He |
| author_facet | Zhaoyang Wang Haixia Chen Jing Yang Xin Du Linbao Zhu Xiao Xu Guangdong Sun Xiuling He |
| author_sort | Zhaoyang Wang |
| collection | DOAJ |
| description | Natural silk, renowned for its remarkable mechanical properties, biocompatibility, degradability, and scalability in production, has become a promising biomaterial for regenerative medicine. Recent advances in silk chemistry and biomaterials engineering have enabled functional modifications of silk and its derived proteins, introduced novel properties, and broadened their application potential. These innovations address limitations in conventional industrial materials, such as hydrogels, scaffolds, and films, thereby significantly expanding their practical utility. This review presents a comprehensive analysis of the structural characteristics of silk and its derived proteins, focusing on the methods used for their extraction, modification, and reprocessing. Furthermore, it explores the latest developments in silk-based biomaterials across three pivotal domains: regenerative medicine, drug delivery, and cosmetics. Finally, the review discusses current challenges and offers insights into the future prospects of silk-based biomaterials. |
| format | Article |
| id | doaj-art-0a544b07eee54b07874e0d7ecd49dfbd |
| institution | OA Journals |
| issn | 0264-1275 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj-art-0a544b07eee54b07874e0d7ecd49dfbd2025-08-20T02:09:18ZengElsevierMaterials & Design0264-12752025-06-0125411402610.1016/j.matdes.2025.114026Engineering silk-based biomaterials: Extraction, modification, and reprocessing strategies in biomedical applicationsZhaoyang Wang0Haixia Chen1Jing Yang2Xin Du3Linbao Zhu4Xiao Xu5Guangdong Sun6Xiuling He7Institute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China; Ningxia Medical University, Yinchuan 750004, ChinaInstitute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaNingxia Medical University, Yinchuan 750004, ChinaInstitute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaInstitute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaInstitute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaInstitute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China; High-Tech Organic Fibers and Composite Materials Key Laboratory of Sichuan Province, Chengdu 610037, China; Corresponding authors.Institute of Sericulture and Tea, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China; Corresponding authors.Natural silk, renowned for its remarkable mechanical properties, biocompatibility, degradability, and scalability in production, has become a promising biomaterial for regenerative medicine. Recent advances in silk chemistry and biomaterials engineering have enabled functional modifications of silk and its derived proteins, introduced novel properties, and broadened their application potential. These innovations address limitations in conventional industrial materials, such as hydrogels, scaffolds, and films, thereby significantly expanding their practical utility. This review presents a comprehensive analysis of the structural characteristics of silk and its derived proteins, focusing on the methods used for their extraction, modification, and reprocessing. Furthermore, it explores the latest developments in silk-based biomaterials across three pivotal domains: regenerative medicine, drug delivery, and cosmetics. Finally, the review discusses current challenges and offers insights into the future prospects of silk-based biomaterials.http://www.sciencedirect.com/science/article/pii/S0264127525004460Silk-based biomaterialsRegenerative medicineDrug deliveryCosmetics |
| spellingShingle | Zhaoyang Wang Haixia Chen Jing Yang Xin Du Linbao Zhu Xiao Xu Guangdong Sun Xiuling He Engineering silk-based biomaterials: Extraction, modification, and reprocessing strategies in biomedical applications Materials & Design Silk-based biomaterials Regenerative medicine Drug delivery Cosmetics |
| title | Engineering silk-based biomaterials: Extraction, modification, and reprocessing strategies in biomedical applications |
| title_full | Engineering silk-based biomaterials: Extraction, modification, and reprocessing strategies in biomedical applications |
| title_fullStr | Engineering silk-based biomaterials: Extraction, modification, and reprocessing strategies in biomedical applications |
| title_full_unstemmed | Engineering silk-based biomaterials: Extraction, modification, and reprocessing strategies in biomedical applications |
| title_short | Engineering silk-based biomaterials: Extraction, modification, and reprocessing strategies in biomedical applications |
| title_sort | engineering silk based biomaterials extraction modification and reprocessing strategies in biomedical applications |
| topic | Silk-based biomaterials Regenerative medicine Drug delivery Cosmetics |
| url | http://www.sciencedirect.com/science/article/pii/S0264127525004460 |
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