Association between O-GlcNAc transferase activity and major adverse cardiovascular events: findings from the China PEACE-MPP cohort
Abstract Background The O-GlcNAc transferase (OGT) levels are closely related to the O-GlcNAcylation of proteins and are also associated with cardiovascular disease. This study explored the association between OGT activity and major adverse cardiovascular events (MACEs) in patients with high cardiov...
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BMC
2025-04-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04732-6 |
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| author | Wei Yu Shiyun Hu Xiaoling Xu Jianlin Shao Jing Yan Fang Ding |
| author_facet | Wei Yu Shiyun Hu Xiaoling Xu Jianlin Shao Jing Yan Fang Ding |
| author_sort | Wei Yu |
| collection | DOAJ |
| description | Abstract Background The O-GlcNAc transferase (OGT) levels are closely related to the O-GlcNAcylation of proteins and are also associated with cardiovascular disease. This study explored the association between OGT activity and major adverse cardiovascular events (MACEs) in patients with high cardiovascular disease risk. This post hoc study included patients from the China PEACE-MPP study in Yi Wu, Zhejiang Province, between 2014 and 2015. Methods The patients were divided into the low and high OGT activity groups according to the median serum OGT value. The outcome was the occurrence of MACEs (cardiovascular death, non-fatal acute myocardial infarction, and non-fatal ischemic stroke). Results Finally, 1947 participants (973 and 974 with low and high OGT activity, respectively) were included. The mean follow-up was 5.56 ± 1.01 years. The participants in the low OGT activity group had a significantly higher occurrence rate of MACEs compared with the high OGT activity group (100 [10.4%] vs. 74 [7.6%], P = 0.032). The Kaplan-Meier analysis showed that the event-free survival rate in the low OGT activity group was significantly lower than in the high OGT activity group (P = 0.036). Multivariable Cox proportional hazards regression analysis showed that after adjustment for age, drinking, hyperglycemia, history of hypertension, and history of cardiovascular and cerebrovascular disease, a high OGT activity was independently associated with a lower risk of MACEs (HR = 0.738, 95%CI: 0.547–0.997, P = 0.048). Conclusions A low OGT activity was independently associated with an increased risk of MACE among patients with a high risk of cardiovascular disease. Trial registration Not applicable. |
| format | Article |
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| institution | DOAJ |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-0a541bed562e4aff82a696045dcf48c22025-08-20T03:10:09ZengBMCBMC Cardiovascular Disorders1471-22612025-04-012511710.1186/s12872-025-04732-6Association between O-GlcNAc transferase activity and major adverse cardiovascular events: findings from the China PEACE-MPP cohortWei Yu0Shiyun Hu1Xiaoling Xu2Jianlin Shao3Jing Yan4Fang Ding5Zhejiang Provincial Center for Cardiovascular Disease Control and Prevention, Zhejiang HospitalZhejiang Provincial Center for Cardiovascular Disease Control and Prevention, Zhejiang HospitalZhejiang Provincial Center for Cardiovascular Disease Control and Prevention, Zhejiang HospitalZhejiang Provincial Center for Cardiovascular Disease Control and Prevention, Zhejiang HospitalZhejiang Provincial Center for Cardiovascular Disease Control and Prevention, Zhejiang HospitalZhejiang Provincial Center for Cardiovascular Disease Control and Prevention, Zhejiang HospitalAbstract Background The O-GlcNAc transferase (OGT) levels are closely related to the O-GlcNAcylation of proteins and are also associated with cardiovascular disease. This study explored the association between OGT activity and major adverse cardiovascular events (MACEs) in patients with high cardiovascular disease risk. This post hoc study included patients from the China PEACE-MPP study in Yi Wu, Zhejiang Province, between 2014 and 2015. Methods The patients were divided into the low and high OGT activity groups according to the median serum OGT value. The outcome was the occurrence of MACEs (cardiovascular death, non-fatal acute myocardial infarction, and non-fatal ischemic stroke). Results Finally, 1947 participants (973 and 974 with low and high OGT activity, respectively) were included. The mean follow-up was 5.56 ± 1.01 years. The participants in the low OGT activity group had a significantly higher occurrence rate of MACEs compared with the high OGT activity group (100 [10.4%] vs. 74 [7.6%], P = 0.032). The Kaplan-Meier analysis showed that the event-free survival rate in the low OGT activity group was significantly lower than in the high OGT activity group (P = 0.036). Multivariable Cox proportional hazards regression analysis showed that after adjustment for age, drinking, hyperglycemia, history of hypertension, and history of cardiovascular and cerebrovascular disease, a high OGT activity was independently associated with a lower risk of MACEs (HR = 0.738, 95%CI: 0.547–0.997, P = 0.048). Conclusions A low OGT activity was independently associated with an increased risk of MACE among patients with a high risk of cardiovascular disease. Trial registration Not applicable.https://doi.org/10.1186/s12872-025-04732-6Major adverse cardiovascular eventsCardiovascular diseasesScreeningSerum markerO-GlcNAc transferase |
| spellingShingle | Wei Yu Shiyun Hu Xiaoling Xu Jianlin Shao Jing Yan Fang Ding Association between O-GlcNAc transferase activity and major adverse cardiovascular events: findings from the China PEACE-MPP cohort BMC Cardiovascular Disorders Major adverse cardiovascular events Cardiovascular diseases Screening Serum marker O-GlcNAc transferase |
| title | Association between O-GlcNAc transferase activity and major adverse cardiovascular events: findings from the China PEACE-MPP cohort |
| title_full | Association between O-GlcNAc transferase activity and major adverse cardiovascular events: findings from the China PEACE-MPP cohort |
| title_fullStr | Association between O-GlcNAc transferase activity and major adverse cardiovascular events: findings from the China PEACE-MPP cohort |
| title_full_unstemmed | Association between O-GlcNAc transferase activity and major adverse cardiovascular events: findings from the China PEACE-MPP cohort |
| title_short | Association between O-GlcNAc transferase activity and major adverse cardiovascular events: findings from the China PEACE-MPP cohort |
| title_sort | association between o glcnac transferase activity and major adverse cardiovascular events findings from the china peace mpp cohort |
| topic | Major adverse cardiovascular events Cardiovascular diseases Screening Serum marker O-GlcNAc transferase |
| url | https://doi.org/10.1186/s12872-025-04732-6 |
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