Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial

Objective. To examine the effects of resistance training relative to aerobic training on abdominal adipose tissue and metabolic variables in adults with prediabetes. Methods. 105 participants with prediabetes were randomized into the resistance training group (RT, n=35), aerobic training group (AT,...

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Main Authors: Juan Yan, Xia Dai, Jitao Feng, Xiaodan Yuan, Jianing Li, Lihong Yang, Panpan Zuo, Zhaohui Fang, Chao Liu, Cunyi Hsue, Junya Zhu, Joshua D. Miller, Qingqing Lou
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2019/8469739
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author Juan Yan
Xia Dai
Jitao Feng
Xiaodan Yuan
Jianing Li
Lihong Yang
Panpan Zuo
Zhaohui Fang
Chao Liu
Cunyi Hsue
Junya Zhu
Joshua D. Miller
Qingqing Lou
author_facet Juan Yan
Xia Dai
Jitao Feng
Xiaodan Yuan
Jianing Li
Lihong Yang
Panpan Zuo
Zhaohui Fang
Chao Liu
Cunyi Hsue
Junya Zhu
Joshua D. Miller
Qingqing Lou
author_sort Juan Yan
collection DOAJ
description Objective. To examine the effects of resistance training relative to aerobic training on abdominal adipose tissue and metabolic variables in adults with prediabetes. Methods. 105 participants with prediabetes were randomized into the resistance training group (RT, n=35), aerobic training group (AT, n=35), and control group (CG, n=35). The participants completed supervised 12-month exercise; the control group followed the primary lifestyle without exercise intervention. The primary outcomes were visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) measured by computed tomography (CT). Secondary outcomes were body composition, lipid profile, and metabolic variables. Results. A total of 93 participants completed the study. There were nonsignificant differences between groups before intervention. After training, VAT decreased significantly in AT and RT compared with CG (P=0.001 and P=0.014, respectively). Although no significant difference in SAT was found across groups, SAT decreased significantly over time within each exercise group (all P=0.001). Increase in muscle mass was greater in RT than that in AT and CG (P=0.031 and P=0.045, respectively). Compared with CG, fasting plasma glucose (FPG) decreased significantly in RT and AT (P=0.003 and P=0.014, respectively). There was a significant difference in the number of prediabetes who converted to diabetes among AT and RT, as compared with the control group (P=0.031 and P=0.011, respectively). No significant differences were observed in lipid, waist-to-hip ratio (WHR), body mass index (BMI), fasting insulin (FI), 2-hour postprandial glucose (2hPG), glycosylated hemoglobin (HbA1c), HOMA-IR, and HOMA-β across groups. Conclusion. Both aerobic training and resistance training are effective in reducing abdominal adipose tissue and fasting plasma glucose in adults with prediabetes. Importantly, resistance training but not aerobic training is effective in augmenting muscle mass. Trial Registration. The trial is registered with NCT02561377 (date of registration: 24/09/2015).
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spelling doaj-art-0a506cdc4d2b45ffafbac4da5d9af1d52025-08-20T02:03:12ZengWileyJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/84697398469739Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled TrialJuan Yan0Xia Dai1Jitao Feng2Xiaodan Yuan3Jianing Li4Lihong Yang5Panpan Zuo6Zhaohui Fang7Chao Liu8Cunyi Hsue9Junya Zhu10Joshua D. Miller11Qingqing Lou12Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, ChinaAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, ChinaAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, ChinaNursing College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, ChinaNursing College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, ChinaUniversity of Massachusetts Amherst, Amherst, MA, USAJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USAStony Brook University Hospital, NY, USAAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, ChinaObjective. To examine the effects of resistance training relative to aerobic training on abdominal adipose tissue and metabolic variables in adults with prediabetes. Methods. 105 participants with prediabetes were randomized into the resistance training group (RT, n=35), aerobic training group (AT, n=35), and control group (CG, n=35). The participants completed supervised 12-month exercise; the control group followed the primary lifestyle without exercise intervention. The primary outcomes were visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) measured by computed tomography (CT). Secondary outcomes were body composition, lipid profile, and metabolic variables. Results. A total of 93 participants completed the study. There were nonsignificant differences between groups before intervention. After training, VAT decreased significantly in AT and RT compared with CG (P=0.001 and P=0.014, respectively). Although no significant difference in SAT was found across groups, SAT decreased significantly over time within each exercise group (all P=0.001). Increase in muscle mass was greater in RT than that in AT and CG (P=0.031 and P=0.045, respectively). Compared with CG, fasting plasma glucose (FPG) decreased significantly in RT and AT (P=0.003 and P=0.014, respectively). There was a significant difference in the number of prediabetes who converted to diabetes among AT and RT, as compared with the control group (P=0.031 and P=0.011, respectively). No significant differences were observed in lipid, waist-to-hip ratio (WHR), body mass index (BMI), fasting insulin (FI), 2-hour postprandial glucose (2hPG), glycosylated hemoglobin (HbA1c), HOMA-IR, and HOMA-β across groups. Conclusion. Both aerobic training and resistance training are effective in reducing abdominal adipose tissue and fasting plasma glucose in adults with prediabetes. Importantly, resistance training but not aerobic training is effective in augmenting muscle mass. Trial Registration. The trial is registered with NCT02561377 (date of registration: 24/09/2015).http://dx.doi.org/10.1155/2019/8469739
spellingShingle Juan Yan
Xia Dai
Jitao Feng
Xiaodan Yuan
Jianing Li
Lihong Yang
Panpan Zuo
Zhaohui Fang
Chao Liu
Cunyi Hsue
Junya Zhu
Joshua D. Miller
Qingqing Lou
Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial
Journal of Diabetes Research
title Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial
title_full Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial
title_fullStr Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial
title_full_unstemmed Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial
title_short Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial
title_sort effect of 12 month resistance training on changes in abdominal adipose tissue and metabolic variables in patients with prediabetes a randomized controlled trial
url http://dx.doi.org/10.1155/2019/8469739
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