Dyadic effects of perceived burden and psychological distress on quality of life among Chinese advanced cancer patients and their caregivers
Abstract This study aims to explore the mediating role of psychological distress in the association between perceived burden and quality of life (QoL) in advanced cancer patient-caregiver dyads. 241 dyads in five tertiary hospitals in a province were investigated by using the Edmonton Symptom Assess...
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-96861-3 |
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| author | Panpan Cui Jiansai Ai Xinyi Chen Chunyan Cheng Jiaoxia Shi Shifeng Li Ming Yang Changying Chen Hengyu Hu |
| author_facet | Panpan Cui Jiansai Ai Xinyi Chen Chunyan Cheng Jiaoxia Shi Shifeng Li Ming Yang Changying Chen Hengyu Hu |
| author_sort | Panpan Cui |
| collection | DOAJ |
| description | Abstract This study aims to explore the mediating role of psychological distress in the association between perceived burden and quality of life (QoL) in advanced cancer patient-caregiver dyads. 241 dyads in five tertiary hospitals in a province were investigated by using the Edmonton Symptom Assessment System, Zarit Burden Interview, the Patient Health Questionnaire-4, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative scores, and the Short Form Health Survey 8. The actor-partner interdependence mediation model (APIMeM), which assesses both individual (actor) and interdependent (partner) effects within dyadic relationships, was employed to analyze how burden and psychological distress interact across dyad members. Analysis was conducted using Mplus v8.0. Regarding the actor effects, the mediating role of psychological distress between perceived burden and QoL was confirmed in advanced cancer patients (B = −0.223, p = 0.001) and their caregivers (B = −0.168, p < 0.001). Regarding the partner effects, there were no significant correlations between caregiver burden and patients’ psychological distress (B = 0.015, p = 0.199), patients’ QoL (B = 0.113, p = 0.278), or the indirect association of caregiver burden with patients’ QoL through psychological distress (B = −0.034, p = 0.259). However, caregivers’ psychological distress was positively correlated with patients’ symptom burden and mediated the association between patients’ symptom burden and caregivers’ QoL (B = −0.090, p = 0.001). The study highlights the importance of taking a dyadic perspective in the context of advanced cancer. Dyadic interventions targeting their perceived burden and psychological distress may be beneficial to their QoL. |
| format | Article |
| id | doaj-art-0a4e45c3a63b4ecfb0ef49205a279fc6 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-0a4e45c3a63b4ecfb0ef49205a279fc62025-08-20T02:28:03ZengNature PortfolioScientific Reports2045-23222025-04-0115111210.1038/s41598-025-96861-3Dyadic effects of perceived burden and psychological distress on quality of life among Chinese advanced cancer patients and their caregiversPanpan Cui0Jiansai Ai1Xinyi Chen2Chunyan Cheng3Jiaoxia Shi4Shifeng Li5Ming Yang6Changying Chen7Hengyu Hu8Department of Nursing, Henan Provincial Key Medicine Laboratory of Nursing, Henan Provincial People’s Hospital, Zhengzhou University People’s HospitalThe Third Affiliated Hospital of Zhengzhou UniversityMedical Oncology, Henan Provincial People’s Hospital, Zhengzhou University People’s HospitalHematology department, Henan Provincial People’s Hospital, Zhengzhou University People’s HospitalMedical Oncology, People’s Hospital of Jiaozuo CityMedical Oncology, Xinyang Central HospitalNursing department, Xinyang Central HospitalThe First Affiliated Hospital of Zhengzhou UniversityDepartment of Nursing, Henan Provincial Key Medicine Laboratory of Nursing, Henan Provincial People’s Hospital, Zhengzhou University People’s HospitalAbstract This study aims to explore the mediating role of psychological distress in the association between perceived burden and quality of life (QoL) in advanced cancer patient-caregiver dyads. 241 dyads in five tertiary hospitals in a province were investigated by using the Edmonton Symptom Assessment System, Zarit Burden Interview, the Patient Health Questionnaire-4, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative scores, and the Short Form Health Survey 8. The actor-partner interdependence mediation model (APIMeM), which assesses both individual (actor) and interdependent (partner) effects within dyadic relationships, was employed to analyze how burden and psychological distress interact across dyad members. Analysis was conducted using Mplus v8.0. Regarding the actor effects, the mediating role of psychological distress between perceived burden and QoL was confirmed in advanced cancer patients (B = −0.223, p = 0.001) and their caregivers (B = −0.168, p < 0.001). Regarding the partner effects, there were no significant correlations between caregiver burden and patients’ psychological distress (B = 0.015, p = 0.199), patients’ QoL (B = 0.113, p = 0.278), or the indirect association of caregiver burden with patients’ QoL through psychological distress (B = −0.034, p = 0.259). However, caregivers’ psychological distress was positively correlated with patients’ symptom burden and mediated the association between patients’ symptom burden and caregivers’ QoL (B = −0.090, p = 0.001). The study highlights the importance of taking a dyadic perspective in the context of advanced cancer. Dyadic interventions targeting their perceived burden and psychological distress may be beneficial to their QoL.https://doi.org/10.1038/s41598-025-96861-3Advanced cancerDyadsCancer-related burdenPsychological distressQuality of life |
| spellingShingle | Panpan Cui Jiansai Ai Xinyi Chen Chunyan Cheng Jiaoxia Shi Shifeng Li Ming Yang Changying Chen Hengyu Hu Dyadic effects of perceived burden and psychological distress on quality of life among Chinese advanced cancer patients and their caregivers Scientific Reports Advanced cancer Dyads Cancer-related burden Psychological distress Quality of life |
| title | Dyadic effects of perceived burden and psychological distress on quality of life among Chinese advanced cancer patients and their caregivers |
| title_full | Dyadic effects of perceived burden and psychological distress on quality of life among Chinese advanced cancer patients and their caregivers |
| title_fullStr | Dyadic effects of perceived burden and psychological distress on quality of life among Chinese advanced cancer patients and their caregivers |
| title_full_unstemmed | Dyadic effects of perceived burden and psychological distress on quality of life among Chinese advanced cancer patients and their caregivers |
| title_short | Dyadic effects of perceived burden and psychological distress on quality of life among Chinese advanced cancer patients and their caregivers |
| title_sort | dyadic effects of perceived burden and psychological distress on quality of life among chinese advanced cancer patients and their caregivers |
| topic | Advanced cancer Dyads Cancer-related burden Psychological distress Quality of life |
| url | https://doi.org/10.1038/s41598-025-96861-3 |
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