Biomedical Significance of Alpha1-Antitrypsin: An Overview
Alpha1-antitrypsin (α1-AT) is a natural, endogenous inhibitor of serine proteases with preferential activity towards neutrophil elastase (NE), the enzyme that possess the ability to cleave important connective tissue protein, elastin. The normal circulating concentrations of α1-AT is thus v...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sri Devaraj Urs Academy of Higher Education and Research
2016-09-01
|
| Series: | Journal of Clinical and Biomedical Sciences |
| Online Access: | https://jcbsonline.ac.in/articles/biomedical-significance-of-alpha1-antitrypsin-an-overview |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Alpha1-antitrypsin (α1-AT) is a natural, endogenous inhibitor of serine proteases with preferential activity towards neutrophil elastase (NE), the enzyme that possess the ability to cleave important connective tissue protein, elastin. The normal circulating concentrations of α1-AT is thus very important to maintain the elasticity of tissues. Severely diminished levels of α1-AT are associated with development of various disease conditions, in particular disorders of lung. This review highlights the biological role of α1-AT and its involvement in diseases. New therapeutic approaches involving α1-AT are also discussed. Keywords: Alpha1-antitrypsin, Endogenous inhibitor, Neutrophil elastase, Serine protease, Serpin. |
|---|---|
| ISSN: | 2231-4180 2319-2453 |