Incidence and Risk Factors for Early Acute Kidney Injury in Nonsurgical Patients: A Cohort Study
Introduction. Detecting acute kidney injury (AKI) in the first days of hospitalization could prevent potentially fatal complications. However, epidemiological data are scarce, especially on nonsurgical patients. Objectives. To determine the incidence and risk factors associated with AKI within five...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2017/5241482 |
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| author | Javier Enrique Cely Elkin José Mendoza Carlos Roberto Olivares Oscar Julián Sepúlveda Juan Sebastián Acosta Rafael Andrés Barón Juan José Diaztagle |
| author_facet | Javier Enrique Cely Elkin José Mendoza Carlos Roberto Olivares Oscar Julián Sepúlveda Juan Sebastián Acosta Rafael Andrés Barón Juan José Diaztagle |
| author_sort | Javier Enrique Cely |
| collection | DOAJ |
| description | Introduction. Detecting acute kidney injury (AKI) in the first days of hospitalization could prevent potentially fatal complications. However, epidemiological data are scarce, especially on nonsurgical patients. Objectives. To determine the incidence and risk factors associated with AKI within five days of hospitalization (EAKI). Methods. Prospective cohort of patients hospitalized in the Internal Medicine Department. Results. A total of 16% of 400 patients developed EAKI. The associated risk factors were prehospital treatment with nephrotoxic drugs (2.21 OR; 95% CI 1.12–4.36, p=0.022), chronic kidney disease (CKD) in stages 3 to 5 (3.56 OR; 95% CI 1.55–8.18, p<0.003), and venous thromboembolism (VTE) at admission (5.05 OR; 95% CI 1.59–16.0, p<0.006). The median length of hospital stay was higher among patients who developed EAKI (8 [IQR 5–14] versus 6 [IQR 4–10], p=0.008) and was associated with an increased requirement for dialysis (4.87 OR 95% CI 2.54 to 8.97, p<0.001) and in-hospital death (3.45 OR; 95% CI 2.18 to 5.48, p<0.001). Conclusions. The incidence of EAKI in nonsurgical patients is similar to the worldwide incidence of AKI. The risk factors included CKD from stage 3 onwards, prehospital treatment with nephrotoxic drugs, and VTE at admission. EAKI is associated with prolonged hospital stay, increased mortality rate, and dialysis requirement. |
| format | Article |
| id | doaj-art-0a405443367348879c6376b31145f5c6 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-0a405443367348879c6376b31145f5c62025-02-03T06:07:34ZengWileyInternational Journal of Nephrology2090-214X2090-21582017-01-01201710.1155/2017/52414825241482Incidence and Risk Factors for Early Acute Kidney Injury in Nonsurgical Patients: A Cohort StudyJavier Enrique Cely0Elkin José Mendoza1Carlos Roberto Olivares2Oscar Julián Sepúlveda3Juan Sebastián Acosta4Rafael Andrés Barón5Juan José Diaztagle6Department of Internal Medicine, Fundación Universitaria de Ciencias de la Salud, San Jose Hospital, School of Medicine, Bogotá, ColombiaDepartment of Internal Medicine, Fundación Universitaria de Ciencias de la Salud, San Jose Hospital, School of Medicine, Bogotá, ColombiaDepartment of Nephrology, Dialysis and Transplantation, Fundación Universitaria de Ciencias de la Salud, San Jose Hospital, School of Medicine, Bogotá, ColombiaDepartment of Internal Medicine, Fundación Universitaria de Ciencias de la Salud, San Jose Hospital, School of Medicine, Bogotá, ColombiaDepartment of Internal Medicine, Fundación Universitaria de Ciencias de la Salud, San Jose Hospital, School of Medicine, Bogotá, ColombiaDepartment of Internal Medicine, Fundación Universitaria de Ciencias de la Salud, San Jose Hospital, School of Medicine, Bogotá, ColombiaDepartment of Internal Medicine, Fundación Universitaria de Ciencias de la Salud, San Jose Hospital, School of Medicine, Bogotá, ColombiaIntroduction. Detecting acute kidney injury (AKI) in the first days of hospitalization could prevent potentially fatal complications. However, epidemiological data are scarce, especially on nonsurgical patients. Objectives. To determine the incidence and risk factors associated with AKI within five days of hospitalization (EAKI). Methods. Prospective cohort of patients hospitalized in the Internal Medicine Department. Results. A total of 16% of 400 patients developed EAKI. The associated risk factors were prehospital treatment with nephrotoxic drugs (2.21 OR; 95% CI 1.12–4.36, p=0.022), chronic kidney disease (CKD) in stages 3 to 5 (3.56 OR; 95% CI 1.55–8.18, p<0.003), and venous thromboembolism (VTE) at admission (5.05 OR; 95% CI 1.59–16.0, p<0.006). The median length of hospital stay was higher among patients who developed EAKI (8 [IQR 5–14] versus 6 [IQR 4–10], p=0.008) and was associated with an increased requirement for dialysis (4.87 OR 95% CI 2.54 to 8.97, p<0.001) and in-hospital death (3.45 OR; 95% CI 2.18 to 5.48, p<0.001). Conclusions. The incidence of EAKI in nonsurgical patients is similar to the worldwide incidence of AKI. The risk factors included CKD from stage 3 onwards, prehospital treatment with nephrotoxic drugs, and VTE at admission. EAKI is associated with prolonged hospital stay, increased mortality rate, and dialysis requirement.http://dx.doi.org/10.1155/2017/5241482 |
| spellingShingle | Javier Enrique Cely Elkin José Mendoza Carlos Roberto Olivares Oscar Julián Sepúlveda Juan Sebastián Acosta Rafael Andrés Barón Juan José Diaztagle Incidence and Risk Factors for Early Acute Kidney Injury in Nonsurgical Patients: A Cohort Study International Journal of Nephrology |
| title | Incidence and Risk Factors for Early Acute Kidney Injury in Nonsurgical Patients: A Cohort Study |
| title_full | Incidence and Risk Factors for Early Acute Kidney Injury in Nonsurgical Patients: A Cohort Study |
| title_fullStr | Incidence and Risk Factors for Early Acute Kidney Injury in Nonsurgical Patients: A Cohort Study |
| title_full_unstemmed | Incidence and Risk Factors for Early Acute Kidney Injury in Nonsurgical Patients: A Cohort Study |
| title_short | Incidence and Risk Factors for Early Acute Kidney Injury in Nonsurgical Patients: A Cohort Study |
| title_sort | incidence and risk factors for early acute kidney injury in nonsurgical patients a cohort study |
| url | http://dx.doi.org/10.1155/2017/5241482 |
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