The rise and evolving role of Fusobacterium nucleatum subspecies
This review examines the classification, distribution, and detection methods of Fusobacterium nucleatum subspecies, focusing on their distinct roles in health and disease. The evolution of F. nucleatum classification is traced from early to modern protein-based and genomic methods, such as 16S rRNA...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Current Research in Microbial Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517425000768 |
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| author | Marietta Wolf Thorsten Steinberg Konstantin Johannes Scholz Anne Kruse Sama Rezasoltani Georg Conrads Ali Al-Ahmad Fabian Cieplik |
| author_facet | Marietta Wolf Thorsten Steinberg Konstantin Johannes Scholz Anne Kruse Sama Rezasoltani Georg Conrads Ali Al-Ahmad Fabian Cieplik |
| author_sort | Marietta Wolf |
| collection | DOAJ |
| description | This review examines the classification, distribution, and detection methods of Fusobacterium nucleatum subspecies, focusing on their distinct roles in health and disease. The evolution of F. nucleatum classification is traced from early to modern protein-based and genomic methods, such as 16S rRNA and next generation sequencing and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). The review highlights the importance of distinguishing F. nucleatum subspecies due to their varying pathogenic potentials and ecological niches in both oral and extraoral environments. Different subspecies exhibit distinct prevalence and activity levels in specific clinical conditions, such as periodontitis and oral squamous cell carcinoma (OSCC). This highlights the importance of accurately identifying subspecies to understand their role in disease progression. Moreover, understanding the varying pathogenic potential of F. nucleatum subspecies, which is driven by genetic diversity and virulence factors, is also essential for advancing research and improving patient outcomes. |
| format | Article |
| id | doaj-art-0a3fe3f427434f71a8b21305f004e8db |
| institution | DOAJ |
| issn | 2666-5174 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-0a3fe3f427434f71a8b21305f004e8db2025-08-20T03:11:26ZengElsevierCurrent Research in Microbial Sciences2666-51742025-01-01910041410.1016/j.crmicr.2025.100414The rise and evolving role of Fusobacterium nucleatum subspeciesMarietta Wolf0Thorsten Steinberg1Konstantin Johannes Scholz2Anne Kruse3Sama Rezasoltani4Georg Conrads5Ali Al-Ahmad6Fabian Cieplik7Department of Operative Dentistry and Periodontology, Center of Dental Medicine, Medical Center & Medical Faculty, University of Freiburg, Germany; Corresponding author at: Department of Operative Dentistry and Periodontology, Center of Dental Medicine, Medical Center & Medical Faculty – University of Freiburg, Hugstetter Str. 55, 79106 Freiburg i. Br., Germany.Division of Oral Biotechnology, Center of Dental Medicine, Medical Center & Medical Faculty, University of Freiburg, GermanyDepartment of Operative Dentistry and Periodontology, Center of Dental Medicine, Medical Center & Medical Faculty, University of Freiburg, GermanyDepartment of Operative Dentistry and Periodontology, Center of Dental Medicine, Medical Center & Medical Faculty, University of Freiburg, GermanyDivision of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology and Preventive Dentistry, Rheinisch-Westfälische Technische Hochschule (RWTH) University Hospital, GermanyDivision of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology and Preventive Dentistry, Rheinisch-Westfälische Technische Hochschule (RWTH) University Hospital, GermanyDepartment of Operative Dentistry and Periodontology, Center of Dental Medicine, Medical Center & Medical Faculty, University of Freiburg, GermanyDepartment of Operative Dentistry and Periodontology, Center of Dental Medicine, Medical Center & Medical Faculty, University of Freiburg, GermanyThis review examines the classification, distribution, and detection methods of Fusobacterium nucleatum subspecies, focusing on their distinct roles in health and disease. The evolution of F. nucleatum classification is traced from early to modern protein-based and genomic methods, such as 16S rRNA and next generation sequencing and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). The review highlights the importance of distinguishing F. nucleatum subspecies due to their varying pathogenic potentials and ecological niches in both oral and extraoral environments. Different subspecies exhibit distinct prevalence and activity levels in specific clinical conditions, such as periodontitis and oral squamous cell carcinoma (OSCC). This highlights the importance of accurately identifying subspecies to understand their role in disease progression. Moreover, understanding the varying pathogenic potential of F. nucleatum subspecies, which is driven by genetic diversity and virulence factors, is also essential for advancing research and improving patient outcomes.http://www.sciencedirect.com/science/article/pii/S2666517425000768F. nucleatum subspeciesOral squamous cell carcinoma (OSCC)Colorectal cancer (CRC)Detection methodsF. nucleatum classification |
| spellingShingle | Marietta Wolf Thorsten Steinberg Konstantin Johannes Scholz Anne Kruse Sama Rezasoltani Georg Conrads Ali Al-Ahmad Fabian Cieplik The rise and evolving role of Fusobacterium nucleatum subspecies Current Research in Microbial Sciences F. nucleatum subspecies Oral squamous cell carcinoma (OSCC) Colorectal cancer (CRC) Detection methods F. nucleatum classification |
| title | The rise and evolving role of Fusobacterium nucleatum subspecies |
| title_full | The rise and evolving role of Fusobacterium nucleatum subspecies |
| title_fullStr | The rise and evolving role of Fusobacterium nucleatum subspecies |
| title_full_unstemmed | The rise and evolving role of Fusobacterium nucleatum subspecies |
| title_short | The rise and evolving role of Fusobacterium nucleatum subspecies |
| title_sort | rise and evolving role of fusobacterium nucleatum subspecies |
| topic | F. nucleatum subspecies Oral squamous cell carcinoma (OSCC) Colorectal cancer (CRC) Detection methods F. nucleatum classification |
| url | http://www.sciencedirect.com/science/article/pii/S2666517425000768 |
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