Signaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell lines.

Signaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell lines.

We have addressed the differential roles of class I Phosphoinositide 3-kinases (PI3K) in human breast-derived MCF10a (and iso-genetic derivatives) and MDA-MB 231 and 468 cells. Class I PI3Ks are heterodimers of p110 catalytic (α, β, δ and γ) and p50-101 regulatory subunits and make the signaling lip...

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Bibliographic Details
Main Authors: Veronique Juvin, Mouhannad Malek, Karen E Anderson, Carine Dion, Tamara Chessa, Charlotte Lecureuil, G John Ferguson, Sabina Cosulich, Phillip T Hawkins, Len R Stephens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0075045
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