Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible Bronchoscopy
Background. The early diagnosis of malignant and premalignant changes of the bronchial mucosa remains a major challenge during bronchoscopy. Intravital staining techniques are not new. Previous small case series suggested that analysis of the bronchial mucosal surface using chromoendoscopy allows a...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/625867 |
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| author | Sabine Zirlik Kai M. Hildner Markus F. Neurath Florian S. Fuchs |
| author_facet | Sabine Zirlik Kai M. Hildner Markus F. Neurath Florian S. Fuchs |
| author_sort | Sabine Zirlik |
| collection | DOAJ |
| description | Background. The early diagnosis of malignant and premalignant changes of the bronchial mucosa remains a major challenge during bronchoscopy. Intravital staining techniques are not new. Previous small case series suggested that analysis of the bronchial mucosal surface using chromoendoscopy allows a prediction between neoplastic and nonneoplastic lesions. Objectives. The aim of the present study was to evaluate chromobronchoscopy as a method to identify malignant and premalignant lesions in the central airways in a prospective manner. Methods. In 26 patients we performed chromoendoscopy with 0.1% methylene blue during ongoing flexible white light bronchoscopy. Circumscribed lesions in central airways were further analyzed by biopsies and histopathologic examination. Results. In the majority of cases neither flat nor polypoid lesions in the central airways were stained by methylene blue. In particular, exophytic growth of lung cancer did not show any specific pattern in chromobronchoscopy. However, a specific dye staining was detected in one case where exophytic growth of metastatic colorectal cancer was present in the right upper lobe. In two other cases, a circumscribed staining was noted in unsuspicious mucosa. But histology revealed inflammation only. Conclusions. In contrast to previous studies, the present findings clearly indicate that chromobronchoscopy is not useful for early detection of malignant or premalignant lesions of the central airways. |
| format | Article |
| id | doaj-art-0a340e325e14408db366c085045210fc |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0a340e325e14408db366c085045210fc2025-02-03T06:01:42ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/625867625867Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible BronchoscopySabine Zirlik0Kai M. Hildner1Markus F. Neurath2Florian S. Fuchs3Department of Medicine, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, GermanyDepartment of Medicine, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, GermanyDepartment of Medicine, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, GermanyDepartment of Medicine, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, GermanyBackground. The early diagnosis of malignant and premalignant changes of the bronchial mucosa remains a major challenge during bronchoscopy. Intravital staining techniques are not new. Previous small case series suggested that analysis of the bronchial mucosal surface using chromoendoscopy allows a prediction between neoplastic and nonneoplastic lesions. Objectives. The aim of the present study was to evaluate chromobronchoscopy as a method to identify malignant and premalignant lesions in the central airways in a prospective manner. Methods. In 26 patients we performed chromoendoscopy with 0.1% methylene blue during ongoing flexible white light bronchoscopy. Circumscribed lesions in central airways were further analyzed by biopsies and histopathologic examination. Results. In the majority of cases neither flat nor polypoid lesions in the central airways were stained by methylene blue. In particular, exophytic growth of lung cancer did not show any specific pattern in chromobronchoscopy. However, a specific dye staining was detected in one case where exophytic growth of metastatic colorectal cancer was present in the right upper lobe. In two other cases, a circumscribed staining was noted in unsuspicious mucosa. But histology revealed inflammation only. Conclusions. In contrast to previous studies, the present findings clearly indicate that chromobronchoscopy is not useful for early detection of malignant or premalignant lesions of the central airways.http://dx.doi.org/10.1100/2012/625867 |
| spellingShingle | Sabine Zirlik Kai M. Hildner Markus F. Neurath Florian S. Fuchs Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible Bronchoscopy The Scientific World Journal |
| title | Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible Bronchoscopy |
| title_full | Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible Bronchoscopy |
| title_fullStr | Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible Bronchoscopy |
| title_full_unstemmed | Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible Bronchoscopy |
| title_short | Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible Bronchoscopy |
| title_sort | methylene blue aided in vivo staining of central airways during flexible bronchoscopy |
| url | http://dx.doi.org/10.1100/2012/625867 |
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