Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line
The paper presents the results of evaluating the genetic and cytogenetic toxicity of etoposide, as well as the evaluation results of protective properties of aspirin against the toxicity of etoposide in C57Bl/6J mice. The cytogenetic activity and protective properties assessment was carried out usin...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2023-10-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/1047 |
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| author | O. N. Antosyuk A. V. Gorskaya D. V. Petrovskii T. D. Dubatolova |
| author_facet | O. N. Antosyuk A. V. Gorskaya D. V. Petrovskii T. D. Dubatolova |
| author_sort | O. N. Antosyuk |
| collection | DOAJ |
| description | The paper presents the results of evaluating the genetic and cytogenetic toxicity of etoposide, as well as the evaluation results of protective properties of aspirin against the toxicity of etoposide in C57Bl/6J mice. The cytogenetic activity and protective properties assessment was carried out using the chromosome aberration analysis in metaphase cells. Etoposide was tested at a concentration of 15 and 3 mg/kg and aspirin — at a concentration of 25 mg/kg of the animal. The results of metaphase analysis showed that etoposide exhibits cytogenetic toxicity in both doses, and aspirin exhibits protective properties against the toxicity of etoposide at a concentration of 15 mg/kg. The results of chromosome analysis regarding the protective properties of aspirin against etoposide at a concentration of 3 mg/kg are ambiguous and require further experiments. |
| format | Article |
| id | doaj-art-0a2d4958416f467e98d3daaec5aa183c |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2023-10-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-0a2d4958416f467e98d3daaec5aa183c2025-08-20T03:20:32ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902023-10-01685-6333810.37489/0235-2990-2023-68-5-6-33-38969Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice LineO. N. Antosyuk0A. V. Gorskaya1D. V. Petrovskii2T. D. Dubatolova3Ural Federal University named after the first President of Russia B. N. YeltsinUral Federal University named after the first President of Russia B. N. YeltsinFederal Research Center «Institute of Cytology and Genetics» of the Siberian Branch of the Russian Academy of Sciences; Institute of Systematics and Ecology of Animals of the Siberian Branch of the Russian Academy of SciencesInstitute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of SciencesThe paper presents the results of evaluating the genetic and cytogenetic toxicity of etoposide, as well as the evaluation results of protective properties of aspirin against the toxicity of etoposide in C57Bl/6J mice. The cytogenetic activity and protective properties assessment was carried out using the chromosome aberration analysis in metaphase cells. Etoposide was tested at a concentration of 15 and 3 mg/kg and aspirin — at a concentration of 25 mg/kg of the animal. The results of metaphase analysis showed that etoposide exhibits cytogenetic toxicity in both doses, and aspirin exhibits protective properties against the toxicity of etoposide at a concentration of 15 mg/kg. The results of chromosome analysis regarding the protective properties of aspirin against etoposide at a concentration of 3 mg/kg are ambiguous and require further experiments.https://www.antibiotics-chemotherapy.ru/jour/article/view/1047etoposideacetylsalicylic acidc57bl / 6j miceprotective propertiescytogenetic toxicitychromosomal aberrations |
| spellingShingle | O. N. Antosyuk A. V. Gorskaya D. V. Petrovskii T. D. Dubatolova Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line Антибиотики и Химиотерапия etoposide acetylsalicylic acid c57bl / 6j mice protective properties cytogenetic toxicity chromosomal aberrations |
| title | Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line |
| title_full | Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line |
| title_fullStr | Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line |
| title_full_unstemmed | Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line |
| title_short | Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line |
| title_sort | study of the toxic manifestation of etoposide the concomitant exposure of acetyl salicylic acid as a protector on the example of c57bl 6j mice line |
| topic | etoposide acetylsalicylic acid c57bl / 6j mice protective properties cytogenetic toxicity chromosomal aberrations |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/1047 |
| work_keys_str_mv | AT onantosyuk studyofthetoxicmanifestationofetoposidetheconcomitantexposureofacetylsalicylicacidasaprotectorontheexampleofc57bl6jmiceline AT avgorskaya studyofthetoxicmanifestationofetoposidetheconcomitantexposureofacetylsalicylicacidasaprotectorontheexampleofc57bl6jmiceline AT dvpetrovskii studyofthetoxicmanifestationofetoposidetheconcomitantexposureofacetylsalicylicacidasaprotectorontheexampleofc57bl6jmiceline AT tddubatolova studyofthetoxicmanifestationofetoposidetheconcomitantexposureofacetylsalicylicacidasaprotectorontheexampleofc57bl6jmiceline |