Ferroptosis in Macrophage Impairment in Sepsis
Sepsis is a clinical syndrome with high mortality, which can lead to multiple organ dysfunction syndrome. Nonspecific immune dysfunction and immune imbalance are its important pathological features. Macrophages are important immune cells and one of the important components of innate and adaptive imm...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.1155/2022/5792866 |
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| author | Hongxuan Liu Lei Li |
| author_facet | Hongxuan Liu Lei Li |
| author_sort | Hongxuan Liu |
| collection | DOAJ |
| description | Sepsis is a clinical syndrome with high mortality, which can lead to multiple organ dysfunction syndrome. Nonspecific immune dysfunction and immune imbalance are its important pathological features. Macrophages are important immune cells and one of the important components of innate and adaptive immunity. Regulating the function of macrophages may be a potential method for the treatment of sepsis. Up to now, ferroptosis has been proved to be involved in the pathophysiological mechanism of many diseases, such as Alzheimer’s disease, cancer, Parkinson’s disease, and renal degeneration. At present, relevant studies have reported that ferroptosis may be involved in the occurrence of sepsis This paper reviews the existing mechanisms of iron ptosis in macrophages in sepsis, with a view to providing si’l for future studies on sepsis. |
| format | Article |
| id | doaj-art-0a2d18ac688a4854bf9e710d1200ae6e |
| institution | Kabale University |
| issn | 1754-2103 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-0a2d18ac688a4854bf9e710d1200ae6e2025-02-03T06:00:55ZengWileyApplied Bionics and Biomechanics1754-21032022-01-01202210.1155/2022/5792866Ferroptosis in Macrophage Impairment in SepsisHongxuan Liu0Lei Li1Department of Emergency Internal MedicineDepartment of Emergency Internal MedicineSepsis is a clinical syndrome with high mortality, which can lead to multiple organ dysfunction syndrome. Nonspecific immune dysfunction and immune imbalance are its important pathological features. Macrophages are important immune cells and one of the important components of innate and adaptive immunity. Regulating the function of macrophages may be a potential method for the treatment of sepsis. Up to now, ferroptosis has been proved to be involved in the pathophysiological mechanism of many diseases, such as Alzheimer’s disease, cancer, Parkinson’s disease, and renal degeneration. At present, relevant studies have reported that ferroptosis may be involved in the occurrence of sepsis This paper reviews the existing mechanisms of iron ptosis in macrophages in sepsis, with a view to providing si’l for future studies on sepsis.http://dx.doi.org/10.1155/2022/5792866 |
| spellingShingle | Hongxuan Liu Lei Li Ferroptosis in Macrophage Impairment in Sepsis Applied Bionics and Biomechanics |
| title | Ferroptosis in Macrophage Impairment in Sepsis |
| title_full | Ferroptosis in Macrophage Impairment in Sepsis |
| title_fullStr | Ferroptosis in Macrophage Impairment in Sepsis |
| title_full_unstemmed | Ferroptosis in Macrophage Impairment in Sepsis |
| title_short | Ferroptosis in Macrophage Impairment in Sepsis |
| title_sort | ferroptosis in macrophage impairment in sepsis |
| url | http://dx.doi.org/10.1155/2022/5792866 |
| work_keys_str_mv | AT hongxuanliu ferroptosisinmacrophageimpairmentinsepsis AT leili ferroptosisinmacrophageimpairmentinsepsis |