Hepatocellular Carcinoma in Delta Hepatitis Versus HBV Monoinfection: Spot the Differences
Background: Hepatitis delta virus (HDV) was recently proven to be directly carcinogenic on hepatocytes via different mechanisms compared to hepatitis B virus (HBV). Our study evaluated the differences between hepatocellular carcinoma (HCC) behaviour in both cases. Methods: A retrospective tertiary c...
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MDPI AG
2025-05-01
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| author | Razvan Cerban Mirela Chitul Speranta Iacob Daria Gheorghe Diana Georgiana Stan Liana Gheorghe |
| author_facet | Razvan Cerban Mirela Chitul Speranta Iacob Daria Gheorghe Diana Georgiana Stan Liana Gheorghe |
| author_sort | Razvan Cerban |
| collection | DOAJ |
| description | Background: Hepatitis delta virus (HDV) was recently proven to be directly carcinogenic on hepatocytes via different mechanisms compared to hepatitis B virus (HBV). Our study evaluated the differences between hepatocellular carcinoma (HCC) behaviour in both cases. Methods: A retrospective tertiary care centre study was conducted and included all HBsAg-positive adult patients admitted from the 1st of January 2021 to the 31st of December 2022. IBM SPSS 29.0 was used for statistics. Patients were split into a control group, HBV + HCC, and a study group, HBV + HDV + HCC. Results: A total of 679 patients were included, with an estimated prevalence of HCC in the HDV population of 20.8% versus 9.1% in the control group, <i>p</i> < 0.001, with an OR = 2.263 and a CI 95% of (1.536–3.333), <i>p</i> = 0.001. Younger patients developed HCC in the HBV monoinfection group (mean ± SD, 50.65 ± 12.302 years vs. 51.4 ± 13.708, <i>p</i> = 0.457). Study group patients had smaller tumours (maximum diameter: 32.66 ± 23.181 mm vs. 56.75 ± 38.09 mm, <i>p</i> = 0.002), lower AFP values (177.24 ± 364.8 ng/mL vs. 183.07 ± 336.77 ng/mL, <i>p</i> = 0.941) and predominantly loco-regional treatment. BCLC classification (<i>p</i> = 0.001) and the AFP-Duvoux score (<i>p</i> = 0.001) showed more advanced HCC in HBV monoinfection, with access to mainly systemic therapies (<i>p</i> < 0.001). Conclusions: HCC is more frequent in HDV-infected patients, leading to a different HCC pattern, with smaller tumours, less advanced neoplasia and less access to curative treatment compared to HBV-monoinfection-associated HCC. |
| format | Article |
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| institution | DOAJ |
| issn | 2673-4389 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Livers |
| spelling | doaj-art-0a1ed7fdd1144a1796695a59fc71ec7e2025-08-20T03:16:19ZengMDPI AGLivers2673-43892025-05-01522310.3390/livers5020023Hepatocellular Carcinoma in Delta Hepatitis Versus HBV Monoinfection: Spot the DifferencesRazvan Cerban0Mirela Chitul1Speranta Iacob2Daria Gheorghe3Diana Georgiana Stan4Liana Gheorghe5Department of Hepatology and Liver Transplantation, Fundeni Clinical Institute, 022328 Bucharest, RomaniaDepartment of Hepatology and Liver Transplantation, Fundeni Clinical Institute, 022328 Bucharest, RomaniaDepartment of Hepatology and Liver Transplantation, Fundeni Clinical Institute, 022328 Bucharest, RomaniaFaculty of General Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of General Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Hepatology and Liver Transplantation, Fundeni Clinical Institute, 022328 Bucharest, RomaniaBackground: Hepatitis delta virus (HDV) was recently proven to be directly carcinogenic on hepatocytes via different mechanisms compared to hepatitis B virus (HBV). Our study evaluated the differences between hepatocellular carcinoma (HCC) behaviour in both cases. Methods: A retrospective tertiary care centre study was conducted and included all HBsAg-positive adult patients admitted from the 1st of January 2021 to the 31st of December 2022. IBM SPSS 29.0 was used for statistics. Patients were split into a control group, HBV + HCC, and a study group, HBV + HDV + HCC. Results: A total of 679 patients were included, with an estimated prevalence of HCC in the HDV population of 20.8% versus 9.1% in the control group, <i>p</i> < 0.001, with an OR = 2.263 and a CI 95% of (1.536–3.333), <i>p</i> = 0.001. Younger patients developed HCC in the HBV monoinfection group (mean ± SD, 50.65 ± 12.302 years vs. 51.4 ± 13.708, <i>p</i> = 0.457). Study group patients had smaller tumours (maximum diameter: 32.66 ± 23.181 mm vs. 56.75 ± 38.09 mm, <i>p</i> = 0.002), lower AFP values (177.24 ± 364.8 ng/mL vs. 183.07 ± 336.77 ng/mL, <i>p</i> = 0.941) and predominantly loco-regional treatment. BCLC classification (<i>p</i> = 0.001) and the AFP-Duvoux score (<i>p</i> = 0.001) showed more advanced HCC in HBV monoinfection, with access to mainly systemic therapies (<i>p</i> < 0.001). Conclusions: HCC is more frequent in HDV-infected patients, leading to a different HCC pattern, with smaller tumours, less advanced neoplasia and less access to curative treatment compared to HBV-monoinfection-associated HCC.https://www.mdpi.com/2673-4389/5/2/23HCCdelta hepatitisHBV infectionmolecular pathwaysBCLC classificationAFP-Duvoux |
| spellingShingle | Razvan Cerban Mirela Chitul Speranta Iacob Daria Gheorghe Diana Georgiana Stan Liana Gheorghe Hepatocellular Carcinoma in Delta Hepatitis Versus HBV Monoinfection: Spot the Differences Livers HCC delta hepatitis HBV infection molecular pathways BCLC classification AFP-Duvoux |
| title | Hepatocellular Carcinoma in Delta Hepatitis Versus HBV Monoinfection: Spot the Differences |
| title_full | Hepatocellular Carcinoma in Delta Hepatitis Versus HBV Monoinfection: Spot the Differences |
| title_fullStr | Hepatocellular Carcinoma in Delta Hepatitis Versus HBV Monoinfection: Spot the Differences |
| title_full_unstemmed | Hepatocellular Carcinoma in Delta Hepatitis Versus HBV Monoinfection: Spot the Differences |
| title_short | Hepatocellular Carcinoma in Delta Hepatitis Versus HBV Monoinfection: Spot the Differences |
| title_sort | hepatocellular carcinoma in delta hepatitis versus hbv monoinfection spot the differences |
| topic | HCC delta hepatitis HBV infection molecular pathways BCLC classification AFP-Duvoux |
| url | https://www.mdpi.com/2673-4389/5/2/23 |
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