The promising role of nanopore sequencing in cancer diagnostics and treatment
Cancer arises from genetic alterations that impact both the genome and transcriptome. The utilization of nanopore sequencing offers a powerful means of detecting these alterations due to its unique capacity for long single-molecule sequencing. In the context of DNA analysis, nanopore sequencing exce...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Cell Insight |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892725000033 |
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| author | Xinming Su Qingyuan Lin Bin Liu Chuntao Zhou Liuyi Lu Zihao Lin Jiahua Si Yuemin Ding Shiwei Duan |
| author_facet | Xinming Su Qingyuan Lin Bin Liu Chuntao Zhou Liuyi Lu Zihao Lin Jiahua Si Yuemin Ding Shiwei Duan |
| author_sort | Xinming Su |
| collection | DOAJ |
| description | Cancer arises from genetic alterations that impact both the genome and transcriptome. The utilization of nanopore sequencing offers a powerful means of detecting these alterations due to its unique capacity for long single-molecule sequencing. In the context of DNA analysis, nanopore sequencing excels in identifying structural variations (SVs), copy number variations (CNVs), gene fusions within SVs, and mutations in specific genes, including those involving DNA modifications and DNA adducts. In the field of RNA research, nanopore sequencing proves invaluable in discerning differentially expressed transcripts, uncovering novel elements linked to transcriptional regulation, and identifying alternative splicing events and RNA modifications at the single-molecule level. Furthermore, nanopore sequencing extends its reach to detecting microorganisms, encompassing bacteria and viruses, that are intricately associated with tumorigenesis and the development of cancer. Consequently, the application prospects of nanopore sequencing in tumor diagnosis and personalized treatment are expansive, encompassing tasks such as tumor identification and classification, the tailoring of treatment strategies, and the screening of prospective patients. In essence, this technology stands poised to unearth novel mechanisms underlying tumorigenesis while providing dependable support for the diagnosis and treatment of cancer. |
| format | Article |
| id | doaj-art-0a137e27329b42ab91de087896c5a452 |
| institution | Kabale University |
| issn | 2772-8927 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj-art-0a137e27329b42ab91de087896c5a4522025-02-08T05:01:45ZengElsevierCell Insight2772-89272025-04-0142100229The promising role of nanopore sequencing in cancer diagnostics and treatmentXinming Su0Qingyuan Lin1Bin Liu2Chuntao Zhou3Liuyi Lu4Zihao Lin5Jiahua Si6Yuemin Ding7Shiwei Duan8Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, Hangzhou City University, Hangzhou 310015, Zhejiang, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medicine University BinJiang College, Hangzhou 310053, Zhejiang, ChinaDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, ChinaDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, ChinaDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, ChinaDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, ChinaDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, Hangzhou City University, Hangzhou 310015, Zhejiang, ChinaDepartment of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, China; Institute of Translational Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, Hangzhou City University, Hangzhou 310015, Zhejiang, China; Corresponding author. Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, China.Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, China; Institute of Translational Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, Hangzhou City University, Hangzhou 310015, Zhejiang, China; Corresponding author. Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, Zhejiang, China.Cancer arises from genetic alterations that impact both the genome and transcriptome. The utilization of nanopore sequencing offers a powerful means of detecting these alterations due to its unique capacity for long single-molecule sequencing. In the context of DNA analysis, nanopore sequencing excels in identifying structural variations (SVs), copy number variations (CNVs), gene fusions within SVs, and mutations in specific genes, including those involving DNA modifications and DNA adducts. In the field of RNA research, nanopore sequencing proves invaluable in discerning differentially expressed transcripts, uncovering novel elements linked to transcriptional regulation, and identifying alternative splicing events and RNA modifications at the single-molecule level. Furthermore, nanopore sequencing extends its reach to detecting microorganisms, encompassing bacteria and viruses, that are intricately associated with tumorigenesis and the development of cancer. Consequently, the application prospects of nanopore sequencing in tumor diagnosis and personalized treatment are expansive, encompassing tasks such as tumor identification and classification, the tailoring of treatment strategies, and the screening of prospective patients. In essence, this technology stands poised to unearth novel mechanisms underlying tumorigenesis while providing dependable support for the diagnosis and treatment of cancer.http://www.sciencedirect.com/science/article/pii/S2772892725000033Nanopore sequencingCancerGenomicsTranscriptomicsMicrobiome |
| spellingShingle | Xinming Su Qingyuan Lin Bin Liu Chuntao Zhou Liuyi Lu Zihao Lin Jiahua Si Yuemin Ding Shiwei Duan The promising role of nanopore sequencing in cancer diagnostics and treatment Cell Insight Nanopore sequencing Cancer Genomics Transcriptomics Microbiome |
| title | The promising role of nanopore sequencing in cancer diagnostics and treatment |
| title_full | The promising role of nanopore sequencing in cancer diagnostics and treatment |
| title_fullStr | The promising role of nanopore sequencing in cancer diagnostics and treatment |
| title_full_unstemmed | The promising role of nanopore sequencing in cancer diagnostics and treatment |
| title_short | The promising role of nanopore sequencing in cancer diagnostics and treatment |
| title_sort | promising role of nanopore sequencing in cancer diagnostics and treatment |
| topic | Nanopore sequencing Cancer Genomics Transcriptomics Microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S2772892725000033 |
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