Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets
We examined the effects of vanadium sulfate (VOSO4) treatment at 5 and 10 mg/kg for 30 days on endocrine pancreas activity and histology in nondiabetic and STZ-induced diabetic rats. In diabetic group, blood glucose levels significantly increased while insulinemia level markedly decreased. At the en...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/540242 |
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| author | Samira Missaoui Khémais Ben Rhouma Mohamed-Tahar Yacoubi Mohsen Sakly Olfa Tebourbi |
| author_facet | Samira Missaoui Khémais Ben Rhouma Mohamed-Tahar Yacoubi Mohsen Sakly Olfa Tebourbi |
| author_sort | Samira Missaoui |
| collection | DOAJ |
| description | We examined the effects of vanadium sulfate (VOSO4) treatment at 5 and 10 mg/kg for 30 days on endocrine pancreas activity and histology in nondiabetic and STZ-induced diabetic rats. In diabetic group, blood glucose levels significantly increased while insulinemia level markedly decreased. At the end of treatment, VOSO4 at a dose of 10 mg/Kg normalized blood glucose level in diabetic group, restored insulinemia, and significantly improved insulin sensitivity. VOSO4 also increased in a dose-dependent manner the number of insulin immunopositive beta cells in pancreatic islets of nondiabetic rats. Furthermore, in the STZ-diabetic group, the decrease in the number of insulin immunopositive beta cells was corrected to reach the control level mainly with the higher dose of vanadium. Therefore, VOSO4 treatment normalized plasma glucose and insulin levels and improved insulin sensitivity in STZ-experimental diabetes and induced beta cells proliferation and/or regeneration in normal or diabetic rats. |
| format | Article |
| id | doaj-art-0a1304444aec41069b0a5fcb82e2f3aa |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-0a1304444aec41069b0a5fcb82e2f3aa2025-08-20T02:03:17ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/540242540242Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic IsletsSamira Missaoui0Khémais Ben Rhouma1Mohamed-Tahar Yacoubi2Mohsen Sakly3Olfa Tebourbi4Laboratory of Integrated Physiology, Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, TunisiaLaboratory of Integrated Physiology, Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, TunisiaDepartment of Pathological Anatomy, Farhat Hached University Hospital, 4000 Sousse, TunisiaLaboratory of Integrated Physiology, Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, TunisiaLaboratory of Integrated Physiology, Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, TunisiaWe examined the effects of vanadium sulfate (VOSO4) treatment at 5 and 10 mg/kg for 30 days on endocrine pancreas activity and histology in nondiabetic and STZ-induced diabetic rats. In diabetic group, blood glucose levels significantly increased while insulinemia level markedly decreased. At the end of treatment, VOSO4 at a dose of 10 mg/Kg normalized blood glucose level in diabetic group, restored insulinemia, and significantly improved insulin sensitivity. VOSO4 also increased in a dose-dependent manner the number of insulin immunopositive beta cells in pancreatic islets of nondiabetic rats. Furthermore, in the STZ-diabetic group, the decrease in the number of insulin immunopositive beta cells was corrected to reach the control level mainly with the higher dose of vanadium. Therefore, VOSO4 treatment normalized plasma glucose and insulin levels and improved insulin sensitivity in STZ-experimental diabetes and induced beta cells proliferation and/or regeneration in normal or diabetic rats.http://dx.doi.org/10.1155/2014/540242 |
| spellingShingle | Samira Missaoui Khémais Ben Rhouma Mohamed-Tahar Yacoubi Mohsen Sakly Olfa Tebourbi Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets Journal of Diabetes Research |
| title | Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets |
| title_full | Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets |
| title_fullStr | Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets |
| title_full_unstemmed | Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets |
| title_short | Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets |
| title_sort | vanadyl sulfate treatment stimulates proliferation and regeneration of beta cells in pancreatic islets |
| url | http://dx.doi.org/10.1155/2014/540242 |
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