Electrochemically Induced, Metal Free Synthesis of 2‐substituted chroman‐4‐ones
Abstract Electrochemically induced, decarboxylative functionalization of chromone‐3‐carboxylic acids by N‐hydroxyphthalimide esters as alkyl radical precursors was studied. Electrochemical protocol offers a sustainable and green approach, obviating the need for catalysts, relying on the direct reduc...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-06-01
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| Series: | ChemistryOpen |
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| Online Access: | https://doi.org/10.1002/open.202400395 |
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| _version_ | 1849468019054477312 |
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| author | Mohsen Monirialamdari Aleksandra Podlaska Dominika Pomikło Anna Albrecht |
| author_facet | Mohsen Monirialamdari Aleksandra Podlaska Dominika Pomikło Anna Albrecht |
| author_sort | Mohsen Monirialamdari |
| collection | DOAJ |
| description | Abstract Electrochemically induced, decarboxylative functionalization of chromone‐3‐carboxylic acids by N‐hydroxyphthalimide esters as alkyl radical precursors was studied. Electrochemical protocol offers a sustainable and green approach, obviating the need for catalysts, relying on the direct reduction of NHPI esters using electric current. Developed protocol provides a straightforward route to the synthesis of diverse molecules with potential biological activity. |
| format | Article |
| id | doaj-art-0a104f9aa33a4132aa2a09b432c25d57 |
| institution | Kabale University |
| issn | 2191-1363 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | ChemistryOpen |
| spelling | doaj-art-0a104f9aa33a4132aa2a09b432c25d572025-08-20T03:25:59ZengWiley-VCHChemistryOpen2191-13632025-06-01146n/an/a10.1002/open.202400395Electrochemically Induced, Metal Free Synthesis of 2‐substituted chroman‐4‐onesMohsen Monirialamdari0Aleksandra Podlaska1Dominika Pomikło2Anna Albrecht3Institute of Organic Chemistry Faculty of Chemistry Lodz University of Technology Żeromskiego 116 90-924 Łódź PolandInstitute of Organic Chemistry Faculty of Chemistry Lodz University of Technology Żeromskiego 116 90-924 Łódź PolandInstitute of Organic Chemistry Faculty of Chemistry Lodz University of Technology Żeromskiego 116 90-924 Łódź PolandInstitute of General and Ecological Chemistry Faculty of Chemistry Lodz University of Technology Żeromskiego 116 90-924 Łódź PolandAbstract Electrochemically induced, decarboxylative functionalization of chromone‐3‐carboxylic acids by N‐hydroxyphthalimide esters as alkyl radical precursors was studied. Electrochemical protocol offers a sustainable and green approach, obviating the need for catalysts, relying on the direct reduction of NHPI esters using electric current. Developed protocol provides a straightforward route to the synthesis of diverse molecules with potential biological activity.https://doi.org/10.1002/open.2024003952-substituted chromonesDecarboxylative alkylationDecarboxylation processElectrochemically induced Giese reactionRedox-Active Esters (RAEs) |
| spellingShingle | Mohsen Monirialamdari Aleksandra Podlaska Dominika Pomikło Anna Albrecht Electrochemically Induced, Metal Free Synthesis of 2‐substituted chroman‐4‐ones ChemistryOpen 2-substituted chromones Decarboxylative alkylation Decarboxylation process Electrochemically induced Giese reaction Redox-Active Esters (RAEs) |
| title | Electrochemically Induced, Metal Free Synthesis of 2‐substituted chroman‐4‐ones |
| title_full | Electrochemically Induced, Metal Free Synthesis of 2‐substituted chroman‐4‐ones |
| title_fullStr | Electrochemically Induced, Metal Free Synthesis of 2‐substituted chroman‐4‐ones |
| title_full_unstemmed | Electrochemically Induced, Metal Free Synthesis of 2‐substituted chroman‐4‐ones |
| title_short | Electrochemically Induced, Metal Free Synthesis of 2‐substituted chroman‐4‐ones |
| title_sort | electrochemically induced metal free synthesis of 2 substituted chroman 4 ones |
| topic | 2-substituted chromones Decarboxylative alkylation Decarboxylation process Electrochemically induced Giese reaction Redox-Active Esters (RAEs) |
| url | https://doi.org/10.1002/open.202400395 |
| work_keys_str_mv | AT mohsenmonirialamdari electrochemicallyinducedmetalfreesynthesisof2substitutedchroman4ones AT aleksandrapodlaska electrochemicallyinducedmetalfreesynthesisof2substitutedchroman4ones AT dominikapomikło electrochemicallyinducedmetalfreesynthesisof2substitutedchroman4ones AT annaalbrecht electrochemicallyinducedmetalfreesynthesisof2substitutedchroman4ones |