A Case of Acquired Rifampin Resistance in Mycobacterium bovis Bacillus Calmette-Guérin-Induced Cystitis: Necessity for Treatment Guidelines
A case of presumed bacillus Calmette-Guérin (BCG) cystitis in an elderly female patient following direct intravesical BCG instillation treatment for papillary transitional cell carcinoma is reported. The organism cultured from urine samples was eventually identified as a rifampin-resistant Mycobacte...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
|
| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2006/263932 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850232213264662528 |
|---|---|
| author | Joyce N Wolfe Kym S Blackwood-Antonation Meenu K Sharma Victoria J Cook |
| author_facet | Joyce N Wolfe Kym S Blackwood-Antonation Meenu K Sharma Victoria J Cook |
| author_sort | Joyce N Wolfe |
| collection | DOAJ |
| description | A case of presumed bacillus Calmette-Guérin (BCG) cystitis in an elderly female patient following direct intravesical BCG instillation treatment for papillary transitional cell carcinoma is reported. The organism cultured from urine samples was eventually identified as a rifampin-resistant Mycobacterium bovis BCG isolate. Because the patient had received rifampin monotherapy during the course of treatment for presumed BCG disease, the clinical picture favoured acquired rifampin resistance. Sequencing of the target gene for rifampin (rpoB) confirmed a known mutation responsible for conferring high levels of resistance to both rifampin and rifabutin (Ser531Tyr). To the authors' knowledge, this is the first reported case of M bovis BCG disease in a non-HIV patient where the organism had acquired drug resistance to rifampin, and the second reported case of M bovis BCG that had acquired drug resistance. The present case demonstrates the necessity to re-evaluate appropriate guidelines for the effective treatment of BCG disease. |
| format | Article |
| id | doaj-art-0a0f097253f14140ba0bd04342517d21 |
| institution | OA Journals |
| issn | 1712-9532 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-0a0f097253f14140ba0bd04342517d212025-08-20T02:03:16ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322006-01-0117318318510.1155/2006/263932A Case of Acquired Rifampin Resistance in Mycobacterium bovis Bacillus Calmette-Guérin-Induced Cystitis: Necessity for Treatment GuidelinesJoyce N Wolfe0Kym S Blackwood-Antonation1Meenu K Sharma2Victoria J Cook3National Reference Centre for Mycobacteriology, National Microbiology Laboratory, Public Health Agency of Canada, CanadaNational Reference Centre for Mycobacteriology, National Microbiology Laboratory, Public Health Agency of Canada, CanadaNational Reference Centre for Mycobacteriology, National Microbiology Laboratory, Public Health Agency of Canada, CanadaTB Control, British Columbia Centre for Disease Control, CanadaA case of presumed bacillus Calmette-Guérin (BCG) cystitis in an elderly female patient following direct intravesical BCG instillation treatment for papillary transitional cell carcinoma is reported. The organism cultured from urine samples was eventually identified as a rifampin-resistant Mycobacterium bovis BCG isolate. Because the patient had received rifampin monotherapy during the course of treatment for presumed BCG disease, the clinical picture favoured acquired rifampin resistance. Sequencing of the target gene for rifampin (rpoB) confirmed a known mutation responsible for conferring high levels of resistance to both rifampin and rifabutin (Ser531Tyr). To the authors' knowledge, this is the first reported case of M bovis BCG disease in a non-HIV patient where the organism had acquired drug resistance to rifampin, and the second reported case of M bovis BCG that had acquired drug resistance. The present case demonstrates the necessity to re-evaluate appropriate guidelines for the effective treatment of BCG disease.http://dx.doi.org/10.1155/2006/263932 |
| spellingShingle | Joyce N Wolfe Kym S Blackwood-Antonation Meenu K Sharma Victoria J Cook A Case of Acquired Rifampin Resistance in Mycobacterium bovis Bacillus Calmette-Guérin-Induced Cystitis: Necessity for Treatment Guidelines Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | A Case of Acquired Rifampin Resistance in Mycobacterium bovis Bacillus Calmette-Guérin-Induced Cystitis: Necessity for Treatment Guidelines |
| title_full | A Case of Acquired Rifampin Resistance in Mycobacterium bovis Bacillus Calmette-Guérin-Induced Cystitis: Necessity for Treatment Guidelines |
| title_fullStr | A Case of Acquired Rifampin Resistance in Mycobacterium bovis Bacillus Calmette-Guérin-Induced Cystitis: Necessity for Treatment Guidelines |
| title_full_unstemmed | A Case of Acquired Rifampin Resistance in Mycobacterium bovis Bacillus Calmette-Guérin-Induced Cystitis: Necessity for Treatment Guidelines |
| title_short | A Case of Acquired Rifampin Resistance in Mycobacterium bovis Bacillus Calmette-Guérin-Induced Cystitis: Necessity for Treatment Guidelines |
| title_sort | case of acquired rifampin resistance in mycobacterium bovis bacillus calmette guerin induced cystitis necessity for treatment guidelines |
| url | http://dx.doi.org/10.1155/2006/263932 |
| work_keys_str_mv | AT joycenwolfe acaseofacquiredrifampinresistanceinmycobacteriumbovisbacilluscalmetteguerininducedcystitisnecessityfortreatmentguidelines AT kymsblackwoodantonation acaseofacquiredrifampinresistanceinmycobacteriumbovisbacilluscalmetteguerininducedcystitisnecessityfortreatmentguidelines AT meenuksharma acaseofacquiredrifampinresistanceinmycobacteriumbovisbacilluscalmetteguerininducedcystitisnecessityfortreatmentguidelines AT victoriajcook acaseofacquiredrifampinresistanceinmycobacteriumbovisbacilluscalmetteguerininducedcystitisnecessityfortreatmentguidelines AT joycenwolfe caseofacquiredrifampinresistanceinmycobacteriumbovisbacilluscalmetteguerininducedcystitisnecessityfortreatmentguidelines AT kymsblackwoodantonation caseofacquiredrifampinresistanceinmycobacteriumbovisbacilluscalmetteguerininducedcystitisnecessityfortreatmentguidelines AT meenuksharma caseofacquiredrifampinresistanceinmycobacteriumbovisbacilluscalmetteguerininducedcystitisnecessityfortreatmentguidelines AT victoriajcook caseofacquiredrifampinresistanceinmycobacteriumbovisbacilluscalmetteguerininducedcystitisnecessityfortreatmentguidelines |