Exploring protein–protein ligation approaches for the cytosolic delivery of antigens using AIP56

Exploring protein–protein ligation approaches for the cytosolic delivery of antigens using AIP56

IntroductionThe intracellular delivery of biologics, particularly large cargoes like proteins, remains a challenge in biotechnology and biomedicine. The modular structure of well-characterized AB toxins allows different cargoes to be grafted, creating a target-specific biotechnological tool capable...

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Bibliographic Details
Main Authors: Bruno Pinheiro, Ana C. Moura, Pedro Oliveira, Jorge E. Azevedo, Ana do Vale, Nuno M. S. dos Santos
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
AB toxins
biologics
cytosolic delivery
protein-protein fusion
AIP56
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1596550/full
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