Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia
Abstract Seizure-related injuries represent a significant concern for both individuals with epilepsy and their caregivers. Compared to the general population, those diagnosed with epilepsy face a heightened risk of sustaining injuries. Despite this, there is a notable scarcity of data regarding seiz...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-86268-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571700449902592 |
|---|---|
| author | Selamawit Wondale Begizew Bethelhem Birhanu Muluneh Taye Mezgebu Ashine Asnakech Zekiwos Heliso Getachew Ossabo Babore Elias Ezo Ereta Sentayehu Admasu Saliya Awoke Girma Hailu Elias Nigusu Abdisa |
| author_facet | Selamawit Wondale Begizew Bethelhem Birhanu Muluneh Taye Mezgebu Ashine Asnakech Zekiwos Heliso Getachew Ossabo Babore Elias Ezo Ereta Sentayehu Admasu Saliya Awoke Girma Hailu Elias Nigusu Abdisa |
| author_sort | Selamawit Wondale Begizew |
| collection | DOAJ |
| description | Abstract Seizure-related injuries represent a significant concern for both individuals with epilepsy and their caregivers. Compared to the general population, those diagnosed with epilepsy face a heightened risk of sustaining injuries. Despite this, there is a notable scarcity of data regarding seizure-related injuries among epileptic patients. This study aimed to evaluate the incidence of seizure-related injuries and identify their predictors among epileptic patients undergoing follow-up treatment at selected public hospitals in Central Ethiopia, in 2023. A prospective follow-up study was carried out in selected public hospitals in central Ethiopia. The study included epileptic patients aged ≥ 18 years who had not experienced any previous injury during follow-up treatment from January 1st, 2023, to December 31st, 2023. Data collection involved conducting interviews with participants using a structured questionnaire and reviewing patients’ charts. Univariate analysis, multivariate, and regression analysis were performed to identify potential associations between variables and seizure-related injuries. Variables were deemed significantly associated with seizure-related injuries if they attained a p value of 0.05 with a 95% confidence interval. Out of the 561 participants, 265 (47.2%) experienced seizure-related injuries (95% CI 43.12, 51.38). The incidence density rate of seizure-related injuries among epileptic patients was 11.97 per 100 person-months of observation (95% CI 10.61, 13.50). In multivariate analysis, epileptic patients who had generalized tonic–clonic seizures (adjusted hazard ratio 1.4, 95% CI 1.07–1.84), comorbidities (adjusted hazard ratio 1.3, 95% CI 1.11–1.71), were on polytherapy drug regimens (adjusted hazard ratio 1.80, 95% CI 0.30–2.49), and consumed alcoholic drinks (adjusted hazard ratio 1.5, 95% CI 1.21–1.89) were identified as independent predictors of seizure-related injuries. The incidence rate of seizure-related injuries among epileptic patients was found to be significant. Risk factors identified included experiencing generalized tonic–clonic seizures, having at least one additional health condition, being on multiple medications, and consuming alcohol. To improve survival from injuries, targeted precautions for generalized tonic–clonic seizures, strict adherence to prescribed medication regimens, and avoiding alcohol consumption are recommended. |
| format | Article |
| id | doaj-art-0a0df7918ecf46c0a91f01edbef5370d |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-0a0df7918ecf46c0a91f01edbef5370d2025-02-02T12:22:23ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-86268-5Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central EthiopiaSelamawit Wondale Begizew0Bethelhem Birhanu Muluneh1Taye Mezgebu Ashine2Asnakech Zekiwos Heliso3Getachew Ossabo Babore4Elias Ezo Ereta5Sentayehu Admasu Saliya6Awoke Girma Hailu7Elias Nigusu Abdisa8Adult Health Nursing, College of Medicine and Health Science, Wachemo UniversityPediatric and Child Health Science, College of Medicine and Health Science, Wachemo UniversityEmergency Medicine and Critical Care Nursing, College of Medicine and Health Science, Wachemo UniversityAdult Health Nursing, College of Medicine and Health Science, Wachemo UniversityPublic Health, College of Medicine and Health Science, Wachemo UniversityMaternity and Reproductive Health Nursing, College of Medicine and Health Science, Wachemo UniversityAdult Health Nursing, College of Medicine and Health Science, Wachemo UniversityAdult Health Nursing, College of Medicine and Health Science, Wachemo UniversityPyschiatry and Mental Illness Nursing, College of Medicine and Health Science, Wachemo UniversityAbstract Seizure-related injuries represent a significant concern for both individuals with epilepsy and their caregivers. Compared to the general population, those diagnosed with epilepsy face a heightened risk of sustaining injuries. Despite this, there is a notable scarcity of data regarding seizure-related injuries among epileptic patients. This study aimed to evaluate the incidence of seizure-related injuries and identify their predictors among epileptic patients undergoing follow-up treatment at selected public hospitals in Central Ethiopia, in 2023. A prospective follow-up study was carried out in selected public hospitals in central Ethiopia. The study included epileptic patients aged ≥ 18 years who had not experienced any previous injury during follow-up treatment from January 1st, 2023, to December 31st, 2023. Data collection involved conducting interviews with participants using a structured questionnaire and reviewing patients’ charts. Univariate analysis, multivariate, and regression analysis were performed to identify potential associations between variables and seizure-related injuries. Variables were deemed significantly associated with seizure-related injuries if they attained a p value of 0.05 with a 95% confidence interval. Out of the 561 participants, 265 (47.2%) experienced seizure-related injuries (95% CI 43.12, 51.38). The incidence density rate of seizure-related injuries among epileptic patients was 11.97 per 100 person-months of observation (95% CI 10.61, 13.50). In multivariate analysis, epileptic patients who had generalized tonic–clonic seizures (adjusted hazard ratio 1.4, 95% CI 1.07–1.84), comorbidities (adjusted hazard ratio 1.3, 95% CI 1.11–1.71), were on polytherapy drug regimens (adjusted hazard ratio 1.80, 95% CI 0.30–2.49), and consumed alcoholic drinks (adjusted hazard ratio 1.5, 95% CI 1.21–1.89) were identified as independent predictors of seizure-related injuries. The incidence rate of seizure-related injuries among epileptic patients was found to be significant. Risk factors identified included experiencing generalized tonic–clonic seizures, having at least one additional health condition, being on multiple medications, and consuming alcohol. To improve survival from injuries, targeted precautions for generalized tonic–clonic seizures, strict adherence to prescribed medication regimens, and avoiding alcohol consumption are recommended.https://doi.org/10.1038/s41598-025-86268-5EpilepticSeizurePredictorsSeizure-related injuryEthiopia |
| spellingShingle | Selamawit Wondale Begizew Bethelhem Birhanu Muluneh Taye Mezgebu Ashine Asnakech Zekiwos Heliso Getachew Ossabo Babore Elias Ezo Ereta Sentayehu Admasu Saliya Awoke Girma Hailu Elias Nigusu Abdisa Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia Scientific Reports Epileptic Seizure Predictors Seizure-related injury Ethiopia |
| title | Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia |
| title_full | Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia |
| title_fullStr | Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia |
| title_full_unstemmed | Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia |
| title_short | Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia |
| title_sort | incidence and predictors of seizure related injuries among epileptic patients undergoing follow up treatment at public hospitals in central ethiopia |
| topic | Epileptic Seizure Predictors Seizure-related injury Ethiopia |
| url | https://doi.org/10.1038/s41598-025-86268-5 |
| work_keys_str_mv | AT selamawitwondalebegizew incidenceandpredictorsofseizurerelatedinjuriesamongepilepticpatientsundergoingfollowuptreatmentatpublichospitalsincentralethiopia AT bethelhembirhanumuluneh incidenceandpredictorsofseizurerelatedinjuriesamongepilepticpatientsundergoingfollowuptreatmentatpublichospitalsincentralethiopia AT tayemezgebuashine incidenceandpredictorsofseizurerelatedinjuriesamongepilepticpatientsundergoingfollowuptreatmentatpublichospitalsincentralethiopia AT asnakechzekiwosheliso incidenceandpredictorsofseizurerelatedinjuriesamongepilepticpatientsundergoingfollowuptreatmentatpublichospitalsincentralethiopia AT getachewossabobabore incidenceandpredictorsofseizurerelatedinjuriesamongepilepticpatientsundergoingfollowuptreatmentatpublichospitalsincentralethiopia AT eliasezoereta incidenceandpredictorsofseizurerelatedinjuriesamongepilepticpatientsundergoingfollowuptreatmentatpublichospitalsincentralethiopia AT sentayehuadmasusaliya incidenceandpredictorsofseizurerelatedinjuriesamongepilepticpatientsundergoingfollowuptreatmentatpublichospitalsincentralethiopia AT awokegirmahailu incidenceandpredictorsofseizurerelatedinjuriesamongepilepticpatientsundergoingfollowuptreatmentatpublichospitalsincentralethiopia AT eliasnigusuabdisa incidenceandpredictorsofseizurerelatedinjuriesamongepilepticpatientsundergoingfollowuptreatmentatpublichospitalsincentralethiopia |