Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress

Background. Research has confirmed the involvement of oxidative stress (OxS) in allergic contact dermatitis whilst other inflammation-related biomarkers have been less studied. Objective. To evaluate systemic levels of selected inflammatory markers, OxS indices and adipokines as well as their associ...

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Main Authors: S. Kaur, K. Zilmer, V. Leping, M. Zilmer
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Dermatology Research and Practice
Online Access:http://dx.doi.org/10.1155/2014/415638
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author S. Kaur
K. Zilmer
V. Leping
M. Zilmer
author_facet S. Kaur
K. Zilmer
V. Leping
M. Zilmer
author_sort S. Kaur
collection DOAJ
description Background. Research has confirmed the involvement of oxidative stress (OxS) in allergic contact dermatitis whilst other inflammation-related biomarkers have been less studied. Objective. To evaluate systemic levels of selected inflammatory markers, OxS indices and adipokines as well as their associations in allergic contact dermatitis. Methods. In 40 patients, interleukin- (IL-) 6, monocyte chemoattractant protein (MCP-1), and IL-10 levels were measured in sera with the Evidence Investigator Cytokine & Growth factors High-Sensitivity Array, total peroxide concentration (TPX) and total antioxidant capacity (TAC) by means of spectrophotometry, and the plasma concentrations of adiponectin and leptin by the quantitative sandwich enzyme immunoassay technique. Results. TNF-α level (P < 0.01) and TPX (P < 0.0001) were increased whilst IL-10 (P < 0.05) and TAC (P < 0.0001) were decreased in the patients as compared to controls. Correlation and multiple linear regression analysis identified both, TPX and TAC (inversely), as possible independent markers for evaluating allergic contact dermatitis. Adiponectin level in patients was increased (P < 0.0001), but neither adiponectin nor leptin correlated significantly with the biomarkers of inflammation or OxS. Conclusion. OxS parameters, especially TPX and OSI, reflect the degree of systemic inflammation associated with allergic contact dermatitis in the best way. The relation between OxS and adiponectin level warrants further studies.
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spelling doaj-art-0a0c8e1e096446cab634cf2e2db607d42025-02-03T01:23:56ZengWileyDermatology Research and Practice1687-61051687-61132014-01-01201410.1155/2014/415638415638Allergic Contact Dermatitis Is Associated with Significant Oxidative StressS. Kaur0K. Zilmer1V. Leping2M. Zilmer3Clinic of Dermatology, University of Tartu, 31 Raja Street, 50417 Tartu, EstoniaInstitute of Biomedicine and Translational Medicine, Department of Biochemistry, the Centre of Excellence for Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, EstoniaInstitute of Computer Science, University of Tartu, 2 J. Liivi Street, 50409 Tartu, EstoniaInstitute of Biomedicine and Translational Medicine, Department of Biochemistry, the Centre of Excellence for Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, EstoniaBackground. Research has confirmed the involvement of oxidative stress (OxS) in allergic contact dermatitis whilst other inflammation-related biomarkers have been less studied. Objective. To evaluate systemic levels of selected inflammatory markers, OxS indices and adipokines as well as their associations in allergic contact dermatitis. Methods. In 40 patients, interleukin- (IL-) 6, monocyte chemoattractant protein (MCP-1), and IL-10 levels were measured in sera with the Evidence Investigator Cytokine & Growth factors High-Sensitivity Array, total peroxide concentration (TPX) and total antioxidant capacity (TAC) by means of spectrophotometry, and the plasma concentrations of adiponectin and leptin by the quantitative sandwich enzyme immunoassay technique. Results. TNF-α level (P < 0.01) and TPX (P < 0.0001) were increased whilst IL-10 (P < 0.05) and TAC (P < 0.0001) were decreased in the patients as compared to controls. Correlation and multiple linear regression analysis identified both, TPX and TAC (inversely), as possible independent markers for evaluating allergic contact dermatitis. Adiponectin level in patients was increased (P < 0.0001), but neither adiponectin nor leptin correlated significantly with the biomarkers of inflammation or OxS. Conclusion. OxS parameters, especially TPX and OSI, reflect the degree of systemic inflammation associated with allergic contact dermatitis in the best way. The relation between OxS and adiponectin level warrants further studies.http://dx.doi.org/10.1155/2014/415638
spellingShingle S. Kaur
K. Zilmer
V. Leping
M. Zilmer
Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress
Dermatology Research and Practice
title Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress
title_full Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress
title_fullStr Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress
title_full_unstemmed Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress
title_short Allergic Contact Dermatitis Is Associated with Significant Oxidative Stress
title_sort allergic contact dermatitis is associated with significant oxidative stress
url http://dx.doi.org/10.1155/2014/415638
work_keys_str_mv AT skaur allergiccontactdermatitisisassociatedwithsignificantoxidativestress
AT kzilmer allergiccontactdermatitisisassociatedwithsignificantoxidativestress
AT vleping allergiccontactdermatitisisassociatedwithsignificantoxidativestress
AT mzilmer allergiccontactdermatitisisassociatedwithsignificantoxidativestress