Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis.

Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis.

<h4>Background</h4>The major clinical challenge in the treatment of high-grade serous ovarian cancer (HGSOC) is the development of progressive resistance to platinum-based chemotherapy. The objective of this study was to determine whether intra-tumour genetic heterogeneity resulting from...

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Main Authors: Roland F Schwarz, Charlotte K Y Ng, Susanna L Cooke, Scott Newman, Jillian Temple, Anna M Piskorz, Davina Gale, Karen Sayal, Muhammed Murtaza, Peter J Baldwin, Nitzan Rosenfeld, Helena M Earl, Evis Sala, Mercedes Jimenez-Linan, Christine A Parkinson, Florian Markowetz, James D Brenton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001789&type=printable
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