Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis
Psychological stress, an evolutionary adaptation to the fight-or-flight response, triggers a number of physiological responses that can be deleterious under some circumstances. Stress signals activate the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system. Elements derive...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/403908 |
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| author | Jessica M. F. Hall desAnges Cruser Alan Podawiltz Diana I. Mummert Harlan Jones Mark E. Mummert |
| author_facet | Jessica M. F. Hall desAnges Cruser Alan Podawiltz Diana I. Mummert Harlan Jones Mark E. Mummert |
| author_sort | Jessica M. F. Hall |
| collection | DOAJ |
| description | Psychological stress, an evolutionary adaptation to the fight-or-flight response, triggers a number of physiological responses that can be deleterious under some circumstances. Stress signals activate the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system. Elements derived from those systems (e.g., cortisol, catecholamines and neuropeptides) can impact the immune system and possible disease states. Skin provides a first line of defense against many environmental insults. A number of investigations have indicated that the skin is especially sensitive to psychological stress, and experimental evidence shows that the cutaneous innate and adaptive immune systems are affected by stressors. For example, psychological stress has been shown to reduce recovery time of the stratum corneum barrier after its removal (innate immunity) and alters antigen presentation by epidermal Langerhans cells (adaptive immunity). Moreover, psychological stress may trigger or exacerbate immune mediated dermatological disorders. Understanding how the activity of the psyche-nervous -immune system axis impinges on skin diseases may facilitate coordinated treatment strategies between dermatologists and psychiatrists. Herein, we will review the roles of the HPA axis and the sympathetic nervous system on the cutaneous immune response. We will selectively highlight how the interplay between psychological stress and the immune system affects atopic dermatitis and psoriasis. |
| format | Article |
| id | doaj-art-09fcdbef0c47467eb0c27eadfe9d8512 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-09fcdbef0c47467eb0c27eadfe9d85122025-02-03T05:48:07ZengWileyDermatology Research and Practice1687-61051687-61132012-01-01201210.1155/2012/403908403908Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and PsoriasisJessica M. F. Hall0desAnges Cruser1Alan Podawiltz2Diana I. Mummert3Harlan Jones4Mark E. Mummert5Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USADepartment of Medical Education, University of North Texas Health Science Center, Fort Worth, TX 76107, USADepartment of Psychiatry and Behavioral Health, University of North Texas Health Science Center, Fort Worth, TX 76107, USADepartment of Psychiatry and Behavioral Health, University of North Texas Health Science Center, Fort Worth, TX 76107, USADepartment of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USADepartment of Psychiatry and Behavioral Health, University of North Texas Health Science Center, Fort Worth, TX 76107, USAPsychological stress, an evolutionary adaptation to the fight-or-flight response, triggers a number of physiological responses that can be deleterious under some circumstances. Stress signals activate the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system. Elements derived from those systems (e.g., cortisol, catecholamines and neuropeptides) can impact the immune system and possible disease states. Skin provides a first line of defense against many environmental insults. A number of investigations have indicated that the skin is especially sensitive to psychological stress, and experimental evidence shows that the cutaneous innate and adaptive immune systems are affected by stressors. For example, psychological stress has been shown to reduce recovery time of the stratum corneum barrier after its removal (innate immunity) and alters antigen presentation by epidermal Langerhans cells (adaptive immunity). Moreover, psychological stress may trigger or exacerbate immune mediated dermatological disorders. Understanding how the activity of the psyche-nervous -immune system axis impinges on skin diseases may facilitate coordinated treatment strategies between dermatologists and psychiatrists. Herein, we will review the roles of the HPA axis and the sympathetic nervous system on the cutaneous immune response. We will selectively highlight how the interplay between psychological stress and the immune system affects atopic dermatitis and psoriasis.http://dx.doi.org/10.1155/2012/403908 |
| spellingShingle | Jessica M. F. Hall desAnges Cruser Alan Podawiltz Diana I. Mummert Harlan Jones Mark E. Mummert Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis Dermatology Research and Practice |
| title | Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis |
| title_full | Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis |
| title_fullStr | Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis |
| title_full_unstemmed | Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis |
| title_short | Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis |
| title_sort | psychological stress and the cutaneous immune response roles of the hpa axis and the sympathetic nervous system in atopic dermatitis and psoriasis |
| url | http://dx.doi.org/10.1155/2012/403908 |
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