Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly
Aims. Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. Methods. Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women,...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/972431 |
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| _version_ | 1849305448412348416 |
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| author | Eriko Yamada Mika Takeuchi Miki Kurata Tsutomu Kazumi Keisuke Fukuo |
| author_facet | Eriko Yamada Mika Takeuchi Miki Kurata Tsutomu Kazumi Keisuke Fukuo |
| author_sort | Eriko Yamada |
| collection | DOAJ |
| description | Aims. Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. Methods. Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of whom had hypertension. Results. Systolic blood pressure (standardized β, 0.775), log tumor necrosis factor-α (TNF-α, standardized β, 0.110), age (standardized β, 0.140), and neutrophil count (standardized β, 0.114) emerged as determinants of PP independent of high-sensitivity C-reactive protein, interleukin-6, monocyte count, plasminogen activator inhibitor-1, homeostasis model assessment of insulin resistance, HDL-cholesterol, and adiponectin (R2 = 0.772). Conclusions. The present studies have demonstrated an independent association of higher PP with higher TNF-α, a marker of insulin resistance, and neutrophil count in community-living elderly women and suggest that insulin resistance and chronic low-grade inflammation may in part be responsible for the association between high PP and incident type 2 diabetes found in elderly patients with hypertension. |
| format | Article |
| id | doaj-art-09f24d7da5044bf88e748aaf61d7948d |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-09f24d7da5044bf88e748aaf61d7948d2025-08-20T03:55:27ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/972431972431Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the ElderlyEriko Yamada0Mika Takeuchi1Miki Kurata2Tsutomu Kazumi3Keisuke Fukuo4Postgraduate School of Food Sciences and Nutrition, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, JapanDepartment of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, JapanDepartment of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, JapanPostgraduate School of Food Sciences and Nutrition, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, JapanPostgraduate School of Food Sciences and Nutrition, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, JapanAims. Elevated pulse pressure (PP) has been reported to be a risk factor for type 2 diabetes in elderly patients with hypertension. Methods. Cross-sectional relationships of PP with known risk factors for type 2 diabetes and inflammatory markers were examined in 150 elderly community-dwelling women, 79 women (52.7%) of whom had hypertension. Results. Systolic blood pressure (standardized β, 0.775), log tumor necrosis factor-α (TNF-α, standardized β, 0.110), age (standardized β, 0.140), and neutrophil count (standardized β, 0.114) emerged as determinants of PP independent of high-sensitivity C-reactive protein, interleukin-6, monocyte count, plasminogen activator inhibitor-1, homeostasis model assessment of insulin resistance, HDL-cholesterol, and adiponectin (R2 = 0.772). Conclusions. The present studies have demonstrated an independent association of higher PP with higher TNF-α, a marker of insulin resistance, and neutrophil count in community-living elderly women and suggest that insulin resistance and chronic low-grade inflammation may in part be responsible for the association between high PP and incident type 2 diabetes found in elderly patients with hypertension.http://dx.doi.org/10.1155/2014/972431 |
| spellingShingle | Eriko Yamada Mika Takeuchi Miki Kurata Tsutomu Kazumi Keisuke Fukuo Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly Journal of Diabetes Research |
| title | Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly |
| title_full | Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly |
| title_fullStr | Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly |
| title_full_unstemmed | Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly |
| title_short | Association of Pulse Pressure with Serum TNF-α and Neutrophil Count in the Elderly |
| title_sort | association of pulse pressure with serum tnf α and neutrophil count in the elderly |
| url | http://dx.doi.org/10.1155/2014/972431 |
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