Dynamic retinal vessel analysis: flickering a light into the brain
IntroductionGrowing aging populations pose new challenges to public health as the number of people living with dementia grows in tandem. To alleviate the burden of dementia, prodromal signs of cognitive impairment must be recognized and risk factors reduced. In this context, non-invasive techniques...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1517368/full |
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| author | Anna Peterfi Anna Peterfi Anna Peterfi Ana Clara da C. Pinaffi-Langley Ana Clara da C. Pinaffi-Langley Zsofia Szarvas Zsofia Szarvas Zsofia Szarvas Mihaly Muranyi Mihaly Muranyi Mihaly Muranyi Zalan Kaposzta Zalan Kaposzta Zalan Kaposzta Cheryl Adams Camila Bonin Pinto Camila Bonin Pinto Peter Mukli Peter Mukli Peter Mukli Konstantin Kotliar Andriy Yabluchanskiy Andriy Yabluchanskiy Andriy Yabluchanskiy Andriy Yabluchanskiy |
| author_facet | Anna Peterfi Anna Peterfi Anna Peterfi Ana Clara da C. Pinaffi-Langley Ana Clara da C. Pinaffi-Langley Zsofia Szarvas Zsofia Szarvas Zsofia Szarvas Mihaly Muranyi Mihaly Muranyi Mihaly Muranyi Zalan Kaposzta Zalan Kaposzta Zalan Kaposzta Cheryl Adams Camila Bonin Pinto Camila Bonin Pinto Peter Mukli Peter Mukli Peter Mukli Konstantin Kotliar Andriy Yabluchanskiy Andriy Yabluchanskiy Andriy Yabluchanskiy Andriy Yabluchanskiy |
| author_sort | Anna Peterfi |
| collection | DOAJ |
| description | IntroductionGrowing aging populations pose new challenges to public health as the number of people living with dementia grows in tandem. To alleviate the burden of dementia, prodromal signs of cognitive impairment must be recognized and risk factors reduced. In this context, non-invasive techniques may be used to identify early changes and monitor disease progression. Dynamic retinal vessel analysis (DVA) provides an opportunity to measure retinal vasoreactivity in a way that may be comparable to cerebral vasoreactivity, thus providing a window to the brain.MethodsWe conducted a literature search on PubMed and Scopus to identify studies utilizing DVA to describe retinal vasoreactivity in central nervous system diseases and compare it with brain function and structure. We included original papers with full text in English.ResultsWe identified 11 studies, of which most employed a cross-sectional design (91%). Studies on cerebrovascular diseases reported that retinal vasoreactivity decreased in patient populations compared with that of healthy controls. Studies on cognitive impairment and dementia yielded mixed results, at least in part due to high population heterogeneity. There is also evidence for the association between DVA and brain and cognition parameters such as cerebral blood flow velocity, cerebral microvascular diffusivity, and cognitive function score.DiscussionThe reviewed papers on DVA and brain function, despite the mixed results, have demonstrated the relationship between retinal vasoreactivity and cerebrovascular function and cognition. Heterogeneity in study populations, procedures, and analyses make comparisons difficult. Studies with larger sample size, clear description of the population and methods, and standardized DVA analysis are needed to elucidate the eye–brain connection and to enhance the translational and clinical applications of DVA. |
| format | Article |
| id | doaj-art-09f041a3eb19413e8468cd38cd403f2a |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-09f041a3eb19413e8468cd38cd403f2a2025-01-06T06:59:03ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-01-011610.3389/fnagi.2024.15173681517368Dynamic retinal vessel analysis: flickering a light into the brainAnna Peterfi0Anna Peterfi1Anna Peterfi2Ana Clara da C. Pinaffi-Langley3Ana Clara da C. Pinaffi-Langley4Zsofia Szarvas5Zsofia Szarvas6Zsofia Szarvas7Mihaly Muranyi8Mihaly Muranyi9Mihaly Muranyi10Zalan Kaposzta11Zalan Kaposzta12Zalan Kaposzta13Cheryl Adams14Camila Bonin Pinto15Camila Bonin Pinto16Peter Mukli17Peter Mukli18Peter Mukli19Konstantin Kotliar20Andriy Yabluchanskiy21Andriy Yabluchanskiy22Andriy Yabluchanskiy23Andriy Yabluchanskiy24Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesVascular Cognitive Impairment and Neurodegeneration Program, Department of Neurosurgery, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesInternational Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, HungaryOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesDepartment of Nutritional Sciences, College of Allied Health, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesVascular Cognitive Impairment and Neurodegeneration Program, Department of Neurosurgery, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesInternational Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, HungaryOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesVascular Cognitive Impairment and Neurodegeneration Program, Department of Neurosurgery, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesInternational Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, HungaryOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesVascular Cognitive Impairment and Neurodegeneration Program, Department of Neurosurgery, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesInternational Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, HungaryOklahoma Shared Clinical and Translational Resources, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesVascular Cognitive Impairment and Neurodegeneration Program, Department of Neurosurgery, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesVascular Cognitive Impairment and Neurodegeneration Program, Department of Neurosurgery, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesInternational Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, HungaryDepartment of Medical Engineering and Technomathematics, Aachen University of Applied Sciences, Juelich, GermanyOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesVascular Cognitive Impairment and Neurodegeneration Program, Department of Neurosurgery, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesDepartment of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesPeggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, United StatesIntroductionGrowing aging populations pose new challenges to public health as the number of people living with dementia grows in tandem. To alleviate the burden of dementia, prodromal signs of cognitive impairment must be recognized and risk factors reduced. In this context, non-invasive techniques may be used to identify early changes and monitor disease progression. Dynamic retinal vessel analysis (DVA) provides an opportunity to measure retinal vasoreactivity in a way that may be comparable to cerebral vasoreactivity, thus providing a window to the brain.MethodsWe conducted a literature search on PubMed and Scopus to identify studies utilizing DVA to describe retinal vasoreactivity in central nervous system diseases and compare it with brain function and structure. We included original papers with full text in English.ResultsWe identified 11 studies, of which most employed a cross-sectional design (91%). Studies on cerebrovascular diseases reported that retinal vasoreactivity decreased in patient populations compared with that of healthy controls. Studies on cognitive impairment and dementia yielded mixed results, at least in part due to high population heterogeneity. There is also evidence for the association between DVA and brain and cognition parameters such as cerebral blood flow velocity, cerebral microvascular diffusivity, and cognitive function score.DiscussionThe reviewed papers on DVA and brain function, despite the mixed results, have demonstrated the relationship between retinal vasoreactivity and cerebrovascular function and cognition. Heterogeneity in study populations, procedures, and analyses make comparisons difficult. Studies with larger sample size, clear description of the population and methods, and standardized DVA analysis are needed to elucidate the eye–brain connection and to enhance the translational and clinical applications of DVA.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1517368/fulldementiabraindynamic vessel analysisretinal vasoreactivityaging |
| spellingShingle | Anna Peterfi Anna Peterfi Anna Peterfi Ana Clara da C. Pinaffi-Langley Ana Clara da C. Pinaffi-Langley Zsofia Szarvas Zsofia Szarvas Zsofia Szarvas Mihaly Muranyi Mihaly Muranyi Mihaly Muranyi Zalan Kaposzta Zalan Kaposzta Zalan Kaposzta Cheryl Adams Camila Bonin Pinto Camila Bonin Pinto Peter Mukli Peter Mukli Peter Mukli Konstantin Kotliar Andriy Yabluchanskiy Andriy Yabluchanskiy Andriy Yabluchanskiy Andriy Yabluchanskiy Dynamic retinal vessel analysis: flickering a light into the brain Frontiers in Aging Neuroscience dementia brain dynamic vessel analysis retinal vasoreactivity aging |
| title | Dynamic retinal vessel analysis: flickering a light into the brain |
| title_full | Dynamic retinal vessel analysis: flickering a light into the brain |
| title_fullStr | Dynamic retinal vessel analysis: flickering a light into the brain |
| title_full_unstemmed | Dynamic retinal vessel analysis: flickering a light into the brain |
| title_short | Dynamic retinal vessel analysis: flickering a light into the brain |
| title_sort | dynamic retinal vessel analysis flickering a light into the brain |
| topic | dementia brain dynamic vessel analysis retinal vasoreactivity aging |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1517368/full |
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