Evaluating third generation cervical Cancer intracavitary interstitial brachytherapy applicator efficacy and safety
Abstract This study evaluated the therapeutic effect of a third-generation intracavitary interstitial brachytherapy (IC-ISBT) technique combined with a source applicator template for locally advanced cervical cancer. This retrospective study examined 113 patients with stage IB3-IVB disease admitted...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-09658-9 |
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| author | Xiang Zhou Xiaodan Huang Yi Ouyang |
| author_facet | Xiang Zhou Xiaodan Huang Yi Ouyang |
| author_sort | Xiang Zhou |
| collection | DOAJ |
| description | Abstract This study evaluated the therapeutic effect of a third-generation intracavitary interstitial brachytherapy (IC-ISBT) technique combined with a source applicator template for locally advanced cervical cancer. This retrospective study examined 113 patients with stage IB3-IVB disease admitted to Sun Yat-sen University Cancer Center between January 2023 and January 2024. The high-risk clinical target area was defined based on residual tumor after external irradiation, and a third-generation IC-ISBT source donor template was developed. We compared the dosimetry and efficacy of the donor template (template interpolation group) and traditional manual implantation method (manual interpolation group) for treating cervical cancer. Regarding dosimetry coverage, the template group differed significantly from the freehand group, showing better target suitability (index) and dose coverage (V100%) (both P < 0.01). Simultaneously, the template protected the rectum and sigmoid colon, potentially reducing the high-dose areas (D0.1 cm³). However, the primary cervical remission rates did not differ significantly between groups. The study findings indicate that the design of the third-generation IC-ISBT applicator template was scientific and reasonable, especially for patients with large tumor volumes and late-stage disease. It is easy to operate and highly reproducible, proving beneficial for dose distribution and protecting surrounding key structures. |
| format | Article |
| id | doaj-art-09edeb47368c4acca58bdeedd5ffbd90 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-09edeb47368c4acca58bdeedd5ffbd902025-08-20T03:45:55ZengNature PortfolioScientific Reports2045-23222025-07-011511610.1038/s41598-025-09658-9Evaluating third generation cervical Cancer intracavitary interstitial brachytherapy applicator efficacy and safetyXiang Zhou0Xiaodan Huang1Yi Ouyang2Department of Oncology, YiYang Central HospitalState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer CenterAbstract This study evaluated the therapeutic effect of a third-generation intracavitary interstitial brachytherapy (IC-ISBT) technique combined with a source applicator template for locally advanced cervical cancer. This retrospective study examined 113 patients with stage IB3-IVB disease admitted to Sun Yat-sen University Cancer Center between January 2023 and January 2024. The high-risk clinical target area was defined based on residual tumor after external irradiation, and a third-generation IC-ISBT source donor template was developed. We compared the dosimetry and efficacy of the donor template (template interpolation group) and traditional manual implantation method (manual interpolation group) for treating cervical cancer. Regarding dosimetry coverage, the template group differed significantly from the freehand group, showing better target suitability (index) and dose coverage (V100%) (both P < 0.01). Simultaneously, the template protected the rectum and sigmoid colon, potentially reducing the high-dose areas (D0.1 cm³). However, the primary cervical remission rates did not differ significantly between groups. The study findings indicate that the design of the third-generation IC-ISBT applicator template was scientific and reasonable, especially for patients with large tumor volumes and late-stage disease. It is easy to operate and highly reproducible, proving beneficial for dose distribution and protecting surrounding key structures.https://doi.org/10.1038/s41598-025-09658-9Cervical cancerBrachytherapySource applicator templateTemplate interpolationManual interpolationDosimetry |
| spellingShingle | Xiang Zhou Xiaodan Huang Yi Ouyang Evaluating third generation cervical Cancer intracavitary interstitial brachytherapy applicator efficacy and safety Scientific Reports Cervical cancer Brachytherapy Source applicator template Template interpolation Manual interpolation Dosimetry |
| title | Evaluating third generation cervical Cancer intracavitary interstitial brachytherapy applicator efficacy and safety |
| title_full | Evaluating third generation cervical Cancer intracavitary interstitial brachytherapy applicator efficacy and safety |
| title_fullStr | Evaluating third generation cervical Cancer intracavitary interstitial brachytherapy applicator efficacy and safety |
| title_full_unstemmed | Evaluating third generation cervical Cancer intracavitary interstitial brachytherapy applicator efficacy and safety |
| title_short | Evaluating third generation cervical Cancer intracavitary interstitial brachytherapy applicator efficacy and safety |
| title_sort | evaluating third generation cervical cancer intracavitary interstitial brachytherapy applicator efficacy and safety |
| topic | Cervical cancer Brachytherapy Source applicator template Template interpolation Manual interpolation Dosimetry |
| url | https://doi.org/10.1038/s41598-025-09658-9 |
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